Objective:To detect the distribution of the (C-106T) single nucleotide polymorphism and genotype of promoter region of aldose reductase gene and to study its relation to the susceptibility of microangiopathy in type 2 diabetes mellitus in Chinese Han from Chongqing.Methods:The aldose reductase gene in promoter region was amplified by polymerase chain reaction and the frequency of genotype of type 2 diabetes were analyzed by restriction enzyme BfaI.Results:The frequencies of genotype CC were significantly higher and the frequencies of genotype TT were much lower in type 2 diabetes patients with microangiopathy than in those without microangiopathy (? 2=6.78 and 4.45,respectively,P

Objective:To analyze autoantibodies in patients with chronic hepatitis B and patients with cirrhosis cused by hepatitis B.Methods:Both antinuclear antibody(ANA)and anti-extracted nuclear antigen(ENA) antibody were detected in 245 patients with chronic hepatitis B and 86 patients with cirrhosis,respectively.Results:The frequencies of ANA were significantly higher ( P

OBJECTIVE: Cerebral endovascular stent implantation has become an important method to treat ischemic cerebrovascular disease. However, its application has been limited by restenosis following implantation. The effect and significance of ultrasound in identifying and reducing restenosis following endovascular stent implantation was explored. METHODS: A computer-based online search of VIP database and CNKI database was performed for articles recording ultrasound evaluation of ischemic cerebrovascular disease following endovascular stent implantation. A total of 22 articles were collected, and 6 were included. Inclusion criteria: application of intravascular ultrasound in carotid artery stent implantation; guidance and effect evaluation of intravascular ultrasound; short- and long-term effect evaluation of carotid artery stent implantation by color Doppler ultrasound and transcranial Doppler ultrasound. Exclusion criteria: outdate and repetitive studies. RESULTS: Intravascular ultrasound can precisely measure vascular lumina stenosis degree, stenosis length and luminal area before stent implantation to select stent with appropriate size and length and effectively guide stent implantation. Intravascular ultrasound probe can observe stent expansion, expansion symmetry, and precisely determine expanded stent size and attachment of stent to the vessel wall. Color Doppler ultrasound and transcranial Doppler ultrasound can monitor the short- and long-term effect of stent implantation so as to discover, treat and reduce restenosis as early as possible, confirm causes for restenosis following stent implantation, guide treatment of restenosis, reduce incidence of restenosis and improve stent implantation effect. CONCLUSION: Intravascular ultrasound remedies disadvantages of digital subtraction angiography, increases stent extension area and reduces incidence of restenosis. Following stent implantation, intravascular ultrasound can accurately detect stent expansion degree and attachment of stent to the vessel wall; Color Doppler ultrasound and transcranial Doppler ultrasound can monitor blood follow in stent, and play an important role in evaluating restenosis and preventing restenosis following endovascular stent implantation.

A semantic predication network was developed by processing the documents on schizophrenia into se-mantic predication sets using SemRep, from which the core information was extracted to produce a graphic summary which was consisted of highly cohesive cliques.The automatic methods for summarizing biomedical documents were studied using the network properties combined with semantic information.The subthemes in the summary obtained by clustering were evaluated according to the clique co-node matrix and the contents of the summary were assessed according to the reference criteria.The accuracy was 0.93, the recall was 0.68, and the F-value was 0.79 for the summary, indicating that this method can effectively recognize the core information in documents and the semantic information in network graphics.

Objective To investigate the therapeutic effect of Ganglioside(GM1) on acute cerebral infarction.Methods 60 cases with acute cerebral infarction were divided into two groups randomly.At the basic of routin treatment for the twe gyoups,GM1 group was treated with GM1 40 mg/d for 14 days and control group was treated with Citicoline 0.75 g/d for 14 days.The neurological deficit scores(NDS),activities of daily living(ADL) and adverse reactions were evaluated.Results After treatment,the scores of NDS and ADL were singnificantly decreased in twe groups than before treatment((P

Objective To study the relationship between hyperferritinemia and early metabolism disturbance of sugar and Lipid.Methods 382 people in health examination from Hangzhou First People's Hospital were divided into hyperferritin group(A group)and hypoferritin group(B group)according to the level of ferritin.Blood fat,fasting blood glucose(FBG),uric acid(UA),hematoglobin(Hb),red blood cell count(RBC),hematocrit(HCT),mean corpuscular-hemoglobin concentration(MCHC)were determined,and adiposis hepatica was judged by ultrasonic inspection,then we analyzed by meams of statistics.Results The result showed that TG,LDL,HDL,ApoA1,ApoB,FBG,UA,Hb,RBC,HCT,MCHC had significant deviation between two groups.Ferritin was positive correlated with TG,TC,LDL,ApoB,Hb,RBC,HCT,and negative correlated with HDL,ApoA1.The incidence of adiposis hepatica in A group was obviously higher than B group.Conclusions Probably,ferritin was one of the markers of early metabolism disturbance of sugar and Lipid.

BACKGROUND:Left ventricle volume or volume index and left ventricle mass or mass index are commonly used to evaluate left ventricle remodeling. Recently,real-time three dimensional echocardiography (RT3DE) has been attempted to evaluate left ventricle remodeling index (LVRI),and it is believed that LVRI can serve as new index to evaluate left ventricle reconstruction clinically. OBJECTIVE:To assess application of RT-3DE in evaluating left ventricular remodeling in patients with hypertension. DESIGN,TIME AND SETTING:Case-control observation was performed at the Department of Ultrasonography,First Hospital of Liaoning Medical University from September 2008 to September 2009. PARTICIPANTS:A total of 90 hypertension patients and 30 normal people were selected. The hypertension patients were divided into 3 subgroups according to interventricular septum,left ventricle myocardial thickness and end-diastolic diameter:normal configuration,concentric hypertrophy and eccentric hypertrophy groups with 30 cases in each group. METHODS:Three dimensional echocardiography of 90 patients and 30 controls was performed. Left ventricular end-diastolic volume (EDV),left ventricular end-diastolic epicardial volume (EDVepi) were measured by RT-3DE; left ventricular mass (LVM),left ventricular mass index (LVMI),left ventricular end-diastolic epicardial volume index (EDVI),LVRI were calculated and compared with two-dimensional echocardiography (2DE) Simpson biplane method. MAIN OUTCOME MEASURES:LVRI,LVMI,and EDVI detected by RT-3DE and 2DE Simpson biplane. RESULTS:LVRI,EDVI,LVMI measured by RT-3DE and 2DE were significantly different in hypertension patients (P 0.05). The LVRI measured by RT-3DE,2DE and EDVI,LVMI measured by 2DE were significantly correlated in normal control,normal configuration and concentric hypertrophy group (P 0.05). CONCLUSION:Real-time three-echocardiographic LVRI can serve as a new approach for evaluating left ventricular remodeling in clinic.

The gene chips have been extensively studies and widely applied.Gene chip technology provides a powerful tool for molecular nutrition.This article reviews the rationales,classification,characteristics of gene chips,and their application in molecular nutrition.

〔Abstract〕 The paper briefly introduces the concept and development process of Electronic Medical Records ( EMR) , elaborates in-formation extraction of EMR as well as the methods assisting clinical decision, including machine learning, statistical learning and rule induction, etc.It describes the application of EMR assisting clinical decision in diagnostic criteria identification and clinical diagnosis ac-tivities, reflects its evidence-based significance.