Objective To evaluate the academic level and the popularity of Chinese Journal of Laboratory Medicine.Method With Chinese Medical Citation Index(CMCI), we analyzed the amount and distribution of the originals in Chinese Journal of Laboratory Medicine cited by the journals indexed in CMCI.Result The percent of cited papers in all published articles was 55.68% during the period, the average number of cited times is 4.83, the top cited value was 108.206 articles (30.03% of total papers) were cited 5 or more, and the all cited times from them were 2428(73.33% of total cited times). 686 cited articles were written by 526 authors from different countries.The most frequently cited author wrote 12 papers, the authors with one paper cited were 430(81.75% of total authors).The cited authors are from the 31 provinces and other country; Beijing, Zhejiang and Shanghai are in the front of Laboratory Medicine research.Beijing was the top of rank (44.40% of total authors).292 institutes were cited and the most frequently cited institute was Beijing Hospital(10.48% of total cited times).There were 563 citing journals where the self-citing rate is 9.85%.Conclusion The Chinese Journal of Laboratory Medicine has published high quality articles. It is the one of the most important information resource for the laboratory medicine researchers and the most important medical journal.

Objective To provide references to NSF funding policy and planning based on the grant project analysis.Methods Funding grants of NSF Distinguished Young Scholars in medical field during 2011-2015 were collected,and compared with the data of 2001-2010.Indicator data was analyzed including grant distribution in supporting institutes,geography locations and medical subject.Results In recent 5 years,the number of application for the grant is increasing,while the funding number stays the same.The universities governed by Ministry of Education and China Academy of Science are the primary grantee institutions.Beijing,Shanghai,and other developed areas got more grants than other provinces.Most grants were focused on oncology,neurology and psychology,medical imaging and medical engineering,and pathogen biology and infection.Conclusions The funding number of NSF supporting for Distinguished Young Scholars should be incresed with applications increasing.The supporting covers in areas,institutes and medical subjects should be extensively.

This paper discussed the selection of SCI journals and questions associated with submitting manuscripts.The strategy for the submitting manuscripts.and the problems in the publication of manuscripts were also summarized in this article.These results would be valuable and guide for the researchers to submit their manuscripts,conform the writing skills of scientific papers,and improve the efficiency of SCI publications.

Objective To analyze the core authors, and their organizations, geographical regional distribution of Chinese Journal of Orthopaedics. Methods The core authors, coauthors and their organizations whose articles were published in Chinese Journal of Orthopaedics between 1995 and 2004 were quantitatively analyzed using literature search through CMCI, which programmed by the People's Liberation Army Medical Library and their geographical regions distribution, the organizations of whom had high quantitative publication were determined using literature metrology methods. Results There were 2660 articles published in Chinese Journal of Orthopaedics between 1995 and 2004. All of 1123 authors of 2660 articles had only one article published which accounted for 69.67% of total first authors on the Chinese Journal of Orthopaedics in ten years. There were 2385 articles with one or more coauthors and the cooperative rate was 89.66%, and cooperative degree was 4.11 in the period of time. There were 275 articles with single author, which accounted for 10.34% of total articles. The articles written by the authors from military hospitals, university affiliated hospitals and provinces-level hospitals were 646(24.28%), 1091(41.01%) and 706(26.54%), respectively during the period. There were 218 core authors with 959(36.05%) articles published and there were 20 high-quantities organizations with 1007(37.86%) articles published in this study. The number one region of published articles was Beijing with 667(25.08%) articles. There were 2443 (91.84%) articles pressed from the organizations of affiliated hospitals of universities, provinces-level hospitals and army hospitals. Among them, Tianjin hospital (101 articles), Beijing Jishuitan hospital (100 articles) and affiliated Xijing hospital of the 4th military medical mniversity (79 articles) occupied 10.53% of the pressed papers and they were in the first three positions. Conclusion Authors of Chinese Journal of Orthopaedics have a wide distribution and highly cooperative rate. There were a group of active and talented core authors who has a great influence on the journal.

Objective To explore the diagnostic value of artificial intelligence (AI) cytology combined with DNA-image cytometry (DNA-ICM) auxiliary diagnostic system for the identification of benign and malignant pleural effusion and ascites. Methods Liquid-based cytology technology (LCT), DNA-ICM, AI, and AI combined with DNA-ICM were used to identify benign and malignant pleural effusion and ascites specimens in 360 cases, and their sensitivity, specificity, accuracy, Kappa value, Youden index and AUC were statistically analyzed. Results The sensitivity, specificity, and accuracy of AI combined with DNA-ICM in detecting benign and malignant pleural effusion and ascites were 95.23%, 94.12%, and 94.44%, respectively, which were higher than those of the three other separate detection methods (all P < 0.05). The kappa values of LCT, DNA-ICM, and AI were 0.646, 0.642, and 0.586; their Youden index values were 0.693, 0.687, and 0.676, and their AUC values were 0.846, 0.843, and 0.838, respectively. The Kappa value of AI combined with DNA-ICM was 0.869, the Youden index was 0.893, and AUC was 0.947, which were all higher than those of the three detection methods alone. Conclusion Among the three separate detection methods, LCT has the highest reliability, authenticity, and diagnostic value, and it can be used as a common method for the clinical identification of benign and malignant pleural effusion and ascites. The diagnostic performance of AI combined with DNA-ICM auxiliary diagnosis system in identifying benign and malignant pleural effusion and ascites is better than those of the three separate detection methods and can be used as a reliable method for the clinical identification of benign and malignant pleural effusion and ascites.

Objective To explore the value of coronary flow reserve(CFR) evaluating myocardial ischemia measured by adenosine triphosphate (ATP) stress transthoracic Doppler echocardiography (TTDE),and the feasibility of CFR to predict coronary stenosis.Methods Fifty-four patients suffering chest pain with known or suspected coronary artery disease were performed ATP stress TTDE to measure resting and maximum expansion coronary blood flow velocity and calculate CFR.all patients were performed by coronary angiography (CAG) and single-photon emission computed tomography (SPECT) myocardial perfusion imaging.Results ① To evaluate myocardial ischemia,there was not statistical significant difference between non-invasive CFR and SPECT myocardial perfusion imaging(P ＞0.05).CFR≤2.0 was the best cutoff value for evaluating myocardial ischemia which yielded a sensitivity of 93.3 ％ and specificity of 89.7％.②Coronary artery stenosis was negatively correlated with CFR (P ＜0.001).ROC curve analysis demonstrated that CFR≤ 1.60 yielded a sensitivity of 92.3％ and specificity of 73.3％ to predict coronary stenosis significantly.Conclusions CFR measured by ATP stress TTDE can evaluate myocardial ischemia of coronary artery disease and predict LAD significant stenosis before CAG.Using CFR and CAG has important clinical value for choosing treatment of stable coronary artery disease.

OBJECTIVE: To observe the difference in the therapeutic effects on rheumatoid arthritis (RA) between the combined -deep needling and bloodletting technique and the regular needling technique. METHODS: A total of 70 patients were randomized into an observation group (35 cases) and a control group (35 cases, 4 cases dropped-out). Dazhui (GV 14), Shenzhu (GV 12), Zhiyang (GV 9), Jinsuo (GV 8), Ganshu (BL 18), Shenshu (BL 23), Zhibian (BL 54), Weizhong (BL 40), Taixi (KI 3) and Tianzong (SI 11), etc. were selected in the two groups. Additionally, in the observation group the -deep needling technique was adopted at Tianzong (SI 11) and Zhibian (BL 54), the bloodletting technique at the local swollen area and the even-needling technique at the rest acupoints. In the control group, the even-needling technique was applied to all of the acupoints. Acupuncture treatment was given once every two days, 3 times a week and for 12 weeks totally. The numbers of tender points at the knee joint, the numbers of swollen sites at the knee joint, the visual analogue scale (VAS) score and the American health assessment questionnaire (HAQ) score were observed in the two groups before and after treatment, as well as the changes in erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). The American College of Rheumatology (ACR) criteria was adopted to evaluate the therapeutic effects of the two groups. RESULTS: After treatment, the numbers of tender points, the numbers of swollen sites, VAS score and HAQ score were all improved as compared with those before treatment in the two groups (all <0.01), and the results in the observation group were better than those in the control group (all <0.05). After treatment, ESR and CRP levels were all reduced as compared with those before treatment in the two groups (all <0.01), but there was no significant differences between the two groups (both >0.05). The standard-reaching rates of ACR 20 and ACR 50 in the observation group were 94.3% (33/35) and 31.4% (11/35) respectively, which were better than 67.7% (21/31) and 6.5% (2/31) in the control group (<0.01, <0.05). CONCLUSION The acupuncture with the -deep and bloodletting techniques and the acupuncture with regular needling technique are all effective on RA. The therapeutic effects of the acupuncture treatment with the -deep and bloodletting techniques are better than that with regular needling technique.
Acupuncture Points ; Acupuncture Therapy ; Arthritis, Rheumatoid ; therapy ; Bloodletting ; Humans ; Treatment Outcome

OBJECTIVETo observe the therapeutic effect of combined therapy of modified Kangjia Recipe (KR) and western medicine propylthiouracil (PTU) on hyperthyroidism and to assess its advantage.

METHODSNinety patients with hyperthyroidism were divided into the treatment group (TG) and the control group (CG). The 60 patients in TG treated with KR and PTU, and the 30 patients in CG treated with PTU alone. The treatment course of both groups was 3 months. The serum thyroid hormone (TH) level, clinical symptoms and signs, and adverse reaction were observed before and after treatment.

RESULTSThe serum TH level, clinical symptoms and signs were significantly improved after treatment in both groups (all P < 0.01). The total effective rate was 93.3% in TG, which was higher than that in CG (83.3%, P < 0.01); and the efficacy in improving palpitation, fidget, aversion to heat, sweating and insomnia was better in the TG than that in the CG respectively (P < 0.05). As for the incidence of adverse reaction, it that was lower in the TG than in the CG.

CONCLUSIONKD has good efficacy in treating hyperthyroidism, and the combined treatment of Chinese and Western medicine shows obvious advantages.

Adult ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; administration & dosage ; Female ; Humans ; Hyperthyroidism ; drug therapy ; Male ; Middle Aged ; Phytotherapy ; Propylthiouracil ; administration & dosage

Melanoma is the most serious type of skin cancer with high metastasis potential and very low survival rate. Although the molecular targeted therapy and immunotherapy have prolonged the survival time of some patients with melanoma in the past few years, a considerable number of patients still can not obtain a longer stable remission period. According to the recent study, melanoma stem cells (MSCs) are one of potential causes of tumor invasion, drug resistance, distant metastasis and recurrence. MSCs can express a variety of cellular markers, and participate into the regulation of tumor-related signal transduction. At the same time, these signaling pathways can retroregulate the expression of cellular markers, and promote the development of melanoma. Therefore, targeting MSCs markers and blocking the related signal transduction pathway can inhibit the growth of melanoma. In this review, the cellular markers, signal transduction mechanism and targeted therapy of MSCs have been discussed in order to provide new ideas for the treatment of melanoma.

Cancer is a global chronic disease and extremely harmful to human health. Cancer patients will have the feeling of become a burden to others in the treatment process, this feeling is called self-perceived burden. self-perceived burden will add to the psychological burden of patients, influence the patient's quality of life and treatment decisions for cancer treatment and recovery. In this article, by analyzing the domestic and foreign scholars on the research of self-perceived burden of cancer patients, highlight the patients self-perceived burden level and influencing factors, provide basis for clinical nursing workers to improve psychological status in cancer patients.