Objective:To investigate the protective effects and possible mechanisms of cortex phellodendri water extract and etha -nol extract on the myocardial injury induced by pituitrin and isoproterenol hydrochloride in rats .Methods:SD rats as the experimental animals were randomly divided into the normal control group , model group , compound Danshen tablets group , phellodendron water ex-tract group and phellodendron ethanol extract group .Pituitrin and isopropyl adrenaline hydrochloride were used to establish the myocar-dial injury model in rats.The serum CK, LDH activity, myocardial tissue SOD activity and MDA content were detected and compared . Results:Compared with those in the normal control group , the serum LDH activity , CK activity and MDA content were significantly in-creased , and the SOD activity in cardiac muscle and myocardial tissue was significantly decreased in the pituitrin -established myocardi-al injury model group (P<0.01).In the isopropyl adrenaline hydrochloride-established myocardial injury model group , the MDA con-tent in myocardial tissue was obviously increased , and the SOD activity in myocardial tissue was decreased obviously (P<0.01).The serum LDH activity, CK activity and MDA content were significantly decreased , and the SOD activity in cardiac muscle and myocardial tissue was increased significantly in all drug-taken groups when compared with those in the pituitrin-established myocardial injury model group, and the differences were statistically significant (P<0.05 or P<0.01).The MDA content in myocardial tissue was significant-ly reduced , and the SOD activity was increased significantly in all drug-taken groups when compared with those in the isopropyl adrena-line hydrochloride-established myocardial injury model group , and the differences were statistically significant (P<0.05 or P<0.01). Conclusion:Cortex phellodendri extract has certain protective effect on myocardial injury induced by pituitrin and isopropyl adrenaline hydrochloride in rats .

OBJECTIVE: To study the relationship between obstructive sleep apnea-hypopnea syndrome (OSAHS) and insulin resistance (IR), then evaluate the effectiveness of the improved Uvulopalatopharyngoplasty (MUPPP) and continuous positive airway pressure (CPAP) on IR. METHOD: Fourteen patients of OSAHS were treated by MUPPP, and sixteen patients of OSAHS were treated by CPAP. All index of the nocturnal polysomnography, fasting plasma insulin, fasting plasma glucose, insulin and blood sugar of 2 hours after meal were analyzed before and after therapy, and 10 patients of OSAHS were untreated by MUPPP or CPAP. The other 33 cases of non-OSAHS were selected as control group. According to the model of HOMA and the formula of LiGuangwei,insulin resistance index and insulin sensitivity index were calculated, respectively. RESULT: There were significant differences between OSAHS group before treatment and control group, before and after treatment, after treatment and untreated group (P < 0.01 or P < 0.05). There was very significant correlation between IAI and LSaO2 (r = 0.633),and there was significantly negative correlation between IAI and AHI (r = -0.654). CONCLUSION OSAHS is an important risk factor for the development of insulin resistance. It shows that OSAHS may develop IR of the patients and the treatment of MUPPP and CPAP can improve insulin sensitivity.
Adult ; Blood Glucose ; metabolism ; Continuous Positive Airway Pressure ; Female ; Humans ; Insulin ; blood ; Insulin Resistance ; Male ; Middle Aged ; Otorhinolaryngologic Surgical Procedures ; Palate ; surgery ; Pharynx ; surgery ; Sleep Apnea, Obstructive ; metabolism ; physiopathology ; surgery ; therapy ; Uvula ; surgery

The 8th Japan-China Hepato-Pancreato-Biliary Symposium was held in Tokyo,Japan from 22nd to 23rd November 2018.The meeting was convened coincidently with the 80th Annual Congress of Japanese Surgical Association,which attracted the participation of Chinese and Japanese hepatobiliary and pancreatic surgeons.The symposium aimed to explore the latest achievements and clinical issues of diagnosis and treatment for hepato-pancreato-biliary diseases.In this article,authors reviewed the up-to-date research information in order to share the experience,achievements and new information in the field of hepatobiliary and pancreatic diseases with colleagues.