Chinese traditional surgery, an important branch of traditional Chinese medicine, has contributed greatly to the people's health in the history. With the fast development of modern medicine, Chinese traditional surgery is faced with serious challenges and its shortcomings have appeared more and more evident. In this article, the authors analyzed some problems in the development of Chinese traditional surgery and the opportunities for its further development, and suggested that the superiorities of Chinese traditional surgery should be enhanced in its future development.

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Object To study the pharmacokinetics of safflower yellow A, a major ingredient in the crude drug of Carthamus tinctorius L., in rats in vivo. Methods RP HPLC method was set up used to determine the content of safflower yellow A in plasma of rat. The chromatographic condition included Hypersil ODS2 column (200 mm?4.6 mm, 5 ?m); the mobile phase consisting of methanol 0.2% acetic acid (24∶76); the flow rate at 0.8 mL/min; the detective wavelength at 410 nm. Riboflavin was used as internal standard. Safflower yellow A was injected into the rats through caudal vein, and its concentrations at different time were determined in healthy rat after 24 h fasting. The data were processed with the software 3P87. Results The primary pharmacokinetic parameters were: V c (0 30?0 04) L/kg, CL (1.12?0.33) mL/min, K e (0.91?0.19) h -1 , t 1/2 (0 76?0 10) h, AUC (24.97?4.83) (?g?h)/mL, respectively in iv safflower yellow A to the rats. Conclusion The safflower yellow A in rats is fited to one compartment model, and it is distributed and eliminated quickly.

Objective To investigate the relationship between expression of REG Iα gene and its clinicopathologic parameters, the survival rate in the patients with primary gastric cancer. Methods Using RT-PCR after extracting RNA from paraffin-embedded materials and immunohistochemical techniques, REG Iα gene expression was investigated in 235 samples. And the relation among their results with the clinicopathologic parameters of primary gastric carcinoma was discussed in experiment by SPSS 13.0 statistic software. Results The positive REG Iα mRNA was 78% (183/235) of primary gastric carcinoma and the positive rate of REG Iα protein was 31.1% (73/235) in 235 patients with primary gastric carcinoma. REG Iα gene expression in infiltrating tumors was found to be significantly higher compared with localized tumors ( P <0.05). REG Iα gene was closely linked to the infiltrative growth pattern, signet ring cell and poorly differentitated adencarcinoma. The incidence of venous invasion of REG Iα gene-positive differentiated adenocarcinoma was significantly higher than that of REG Iα gene-negative tumors. Moreover, the patients with REG Iα gene-positive differentiated adenocarcinoma were found to have a significantly poorer prognosis as compared with REG Iα gene-negative tumor patients. Conclusions The results of the experiment demonstrated that the expression of the REG Iα gene is closely related to the infiltrating property of primary gastric carcinoma. Signet ring cells and poorly differentiated adencarcinoma significantly enhance the risk of venous invasion of REG Iα gene-positive differentiated adenocarcinoma and might be as a prognostic indicator of differentiated adenocarcinoma of the stomach in clinic diagnosis.

Objective To study the expression of integrin ?1 in hepatocellular carcinoma (HCC) and its significance. Methods Integrin ?1 expression was detected in 38 cases of HCC, 8 cases of hepatic cirrhosis (HC) and 7 cases of normal liver tissues(NL) using immunohistochemical SP method. The relationship between the integrin ?1 expression and HCC clinico-pathological features was analyzed. Results The positive rate of integrin ?1 expression in the HCC was much higher than that in the HC and NL tissues (P

Objective: To analyze the epidemic characteristics of enterovirus infection in Yueqing city from 2010 to 2018, and to provide reference for the prevention and control of hand, foot and mouth disease (HFMD) caused by enterovirus. Methods: Clinical data of HFMD cases caused by enterovirus infection during 2010 to 2018 were derived from the disease monitoring information report management system of Yueqing city. Descriptive epidemiological study was performed to analyze the characteristics of enterovirus infection by season, age, gender and region and the features of pathogens. Results: There were 53 178 patients with HFMD in total, including 75 severe cases and six deaths. Enterovirus infection occurred in every month of the years and peaked from April to July. Most of the cases were scattered children and nursery children under five years old and the incidence was higher in males than in females. From 2010 to 2018, the characteristics of enterovirus in Yueqing city had changed significantly. Enterovirus 71 (EV71) was the predominant pathogen during 2010 to 2014, but its detection rate had gradually decreased since 2013. In recent years, the incidence of HFMD caused by non-EV71 and non-coxsackievirus A16 (non-CVA16) enteroviruses significantly increased. Conclusions Enterovirus infection in Yueqing city was featured by significant seasonality and population-specific variation. Etiological detection should be strengthened. Comprehensive prevention and control measures should be taken to prevent the outbreak of HFMD during April to July.

Objective To explore the expression of tenascin in hepatocellular carcinoma (HCC). Methods With the method of immunohistochemical staining, specimens from 42 HCC patients, 10 hepatic cirrhotics and 7 normal liver controls were studied. The relationship between the tenascin expression and pathological features as well as microvessel density (MVD) was evaluated. Results The expression of tenascin in the HCC tissues was much higher than that in the non-HCC tissues ( ? 2=4.15, P

Objective: To analyze the status quo of assanation and ethics courses and their social requirement, thus to explore a scientific mode for the course setting; Method: The course setting status quo of assanation and ethics is analyzed among 18 colleges in which the nursing speciality is set up. A questionnaire was also conducted to investigate students' inclination towards politics-sorted courses, and relevant data were analyzed. Results: The establishing rate of assanation courses in the higher professional colleges is higher than that in the comprehensive universities. The most favorable subjects among freshmen are the Chinese national political theories, and assanation & ethics, while the counterparts among seniors are assanation & ethics, law basis, and philosophy. Seniors have an obvious higher desire for the course of assanation & ethics compared with freshmen (P

The present article reviews the progress in the experimental studies of traditional Chinese medicine for benign prostatic hyperplasia (BPH) in the recent years. Traditional Chinese medicine can inhibit prostatic hyperplasia, after the growth factor of prostate cell proliferation, regulate nerves and endocrine, and act on the kinetic factor (alpha-receptor) and static factor (augmented prostate) of BPH formation. We also investigate the selection of the animal model of prostatic hyperplasia. It has certain directive effect to further discover the action mechanism of traditional Chinese medicine in the treatment of BPH.
Animals ; Disease Models, Animal ; Dogs ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Male ; Mice ; Phytotherapy ; Prostatic Hyperplasia ; drug therapy ; Rats

Objective To assess the long-term surgical outcomes,patient's satisfaction and functional results of correction for patients with penile curvature by 16-dot minimal tension plication.Methods Between August 2004 and December 2010,92 patients with penile curvature underwent surgical correction of penile curvature by 16-dot minimal tension plication.Of them,86 patients (53 patients with congenital penile curvature and 33 patients with Peyronie's disease (PD)) were reached for long-term follow-up.Indications for operation included patients with 30 to 90 degrees of penile curvature,penile length greater than 10 cm and patients who had one or more symptoms,such as difficulty or inability to vaginal penetration and partner discomfort during sexual intercourse.Patients were excluded from study if they had severe penile curvature (greater than 90 degrees),hourglass deformities or large plaques.Preoperative evaluation included international index of erectile function 5 (IIEF-5) questionnaire score,pain on erection and physical examination.Patients were recommended daily low dose phosphodiesterase type 5 (PDE-5) inhibitors 2 weeks after surgery and maintained for 2 to 3 months.At follow-up,recurrence rate,complications,erectile function,patients and partner's satisfaction with the surgery were assessed.Results The mean time of follow-up was 79 months (range,35-107 months).Of 86 patients who had been reached for long-term follow up,82 patients (95.3％) and 77 partners (89.5％) reported overall satisfaction after the surgery.Complete penile straightening was achieved in 79 patients (91.8％).Slight residual curvatures were observed in 7 patients,but did not affect their sexual intercourse.Postoperative penile length shortening (median penile length loss 1.3 cm) was noted in 35 patients (40.7％),which did not affect their sexual intercourse.In addition,no de novo erectile dysfunction was observed,and sexual function was significantly improved evidenced by the IIEF-5 scores,especially in the patients who had received PDE-5 inhibitors for 2 to 3 months.There were no surgery-related complications,such as hematoma,urethral injury,or infection.Conclusion The longterm results demonstrate that correction of penile curvature using 16-dot plication is a simple and safe method to achieve cosmetic and functional satisfaction in patients with mild to moderate penile curvature.