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Objective:To detect the distribution of the receptor for advanced glycation end products(RAGE) in gingival tissues of patients with non-insulin dependent diabetes mellitus(NIDDM) accompanying periodontitis.Methods:5 patients with chronic periodontitits(CP) and 4 patients with NIDDM accompanying periodontitis were included. Immunohistochemical staining was performed to detect RAGE and tumor necrosis factor ?(TNF-?) expression in gingival tissues.Interleukin 6(IL-6) and TNF-? levels in gingival crevicular fluid and serum of these patients were examined by ELISA.Results:More RAGE cells were observed in the gingival tissus in the patients of NIDDM with CP than in those of CP(P0.05).Conclusion:RAGE may play a role in the destruction of periodontal tissues in NIDDM patients with CP.

Objective:To survey the periodontal status of patients with metabolic syndrome in a Beijing community,so as to evaluate the relationship between periodontal status and metabolic syndrome.Methods:152 metabolic syndrome(MS)patients,106 post-acute myocardial infarction patients,211 hypertension patients and 56 healthy subjects were involved.Mesial buccal and distal lingual sites per tooth were examined.The periodontal status including plaque index(PLI),bleeding index(BI),probing depth(PD)and attachment loss(AL)as well as missing teeth number were recorded.Results:In male patients,PLI,BI and PD in MS group were higher than that in the other three groups although the mean age and smoking percentage of MS group were the lowest(P

Objective:To evaluate the effect of decalcified freeze-dried bone allograft(DFDBA) and DFDBA with platelet-rich plasma(PRP) in the treatment of periodontal infrabony defects.Methods: Fifteen periodontal infrabony defects(30 sites) in 12 patients with periodontitis(9 patients with chronic periodontitis and 3 patients with aggressive periodontitis) were selected.Three months after initial therapy,they were assigned to either the DFDBA group(10 defects with 20 sites) or the DFDBA with PRP group(5 defects with 10 sites).The patients were evaluated for plaque index(PI),bleeding index(BI),probing depths(PD) and clinical attachment loss(CAL) before the treatment and at 6 months after periodontal bone graft surgery.Results: The PI,BI,PD and CAL in the DFDBA group were 1.7,2.7,6.0 mm and 7.0 mm at baseline;1.5,1.8,3.9 mm and 4.4 mm at the 6 months after periodontal surgery.The PD,CAL and BI in DFDBA with PRP group at baseline were 6.2 mm,7.1 mm and 2.9;3.2 mm,3.6 mm and 1.7 at the 6 months after periodontal surgery.The PI did not change significantly after surgery in both groups.While both groups showed significant improvement(P

Objective: To compare the effecte of removing plaque by two toothbrushing methods. Methods: Forty subjects were chosen to take part in the randomized、examiner-blind、crossover study. Results: Modified Bass method has better effect of removing plaque, especially that at the central margin than Vertical method(P

Acne Vulgaris ; complications ; Follow-Up Studies ; Humans ; Osteolysis ; etiology ; Time Factors ; Tooth Socket

OBJECTIVETo evaluate the oral health-related quality of life (OHRQOL) in type 2 diabetic patients with chronic periodontitis.

METHODSA total of 80 type 2 diabetic patients with chronic periodontitis who had at least 16 teeth and never accept any periodontal therapy in latest one year were recruited. The clinical periodontal index such as probing depth, attachment loss (AL), modified bleeding index, plaque index were obtained with a Williams type periodontal probe. All accepted structured questionnaire interview including the evaluation of OHRQOL.

RESULTSThe geriatric oral health assessment index (GOHAI) results demonstrated good content validity, construct validity and responsibility. The periodontal index had positive correlation with the GOHAI scores. Individuals with self-unsatisfied of oral health status, using hypoglycemic drugs, accompanied with serious gingival inflammation and higher AL had relatively poor OHRQOL.

CONCLUSIONThe OHRQOL of type 2 diabetes with chronic periodontitis and the negative experiences of items listed in GOHAI questionnaire were affected by self-conscious of oral health and periodontal inflammation status.

Chronic Periodontitis ; Dental Plaque Index ; Diabetes Mellitus, Type 2 ; Humans ; Male ; Middle Aged ; Oral Health ; Periodontal Index ; Quality of Life ; Surveys and Questionnaires

OBJECTIVETo assess the relationship between oral malodor, volatile sulphur compounds (VSCs) levels in the mouth air and periodontal index; the role of tongue in the production of VSCs and halitosis.

METHODS60 periodontitis patients with oral malodor were included. Oral malodor was estimated by organoleptic method (organoleptic rating, OR); VSCs level measurements before and after cleaning the tongue coating were made with a portable sulphide monitor (halimeter), respectively; periodontal probing depth (PD) and the proportion of PD >/= 4 mm sites, bleeding index (BI) and plaque index (PLI) were examined; tongue coating was estimated with thickness (Tt) and area (Ta) on the dorsal surface of tongue.

RESULTSThe correlation was analyzed with Spearman method. There was a significantly positive correlation between OR, VSCs levels and BI, PLI, and Tt, respectively (P < 0.01). OR and VSCs levels was also related with Ta (P < 0.05). There was a weakly correlation between VSCs levels and PD, and the proportion of PD >/= 4 mm sites (r = 0.26, P < 0.05). No correlation between OR and PD, and the proportion of PD >/= 4 mm sites was existed. Reduction of VSCs levels after cleaning tongue coating was statistically significant (t = 10.15, P < 0.01), and also significantly related with thickness and area of tongue coating (P < 0.01).

CONCLUSIONSIn present study, OR and VSCs levels were significantly correlated with gingival inflammation (BI), condition of oral hygiene (PLI), and tongue coating. The relationship between OR, VSCs levels and periodontal probing depth was not found obviously. VSCs levels were significantly reduced after cleaning tongue coating, but the percentage of reduction was less than that of the previous studies.

Dental Plaque Index ; Halitosis ; Humans ; Periodontitis ; Sulfur Compounds

OBJECTIVETo evaluate the effects of local-delivery of 25% metronidazol gel and mechanical cleaning using ultrasonic carbon fiber tip on dental implants with peri-implantitis.

METHODS27 implants with peri-implantitis were randomly assigned to receiving either 25% metronidazol gel treatment or carbon fiber tip ultrasonic scaling. All parameters including plaque index (PLI), probing depth (PD) of pocket, sulcular bleeding index (SBI), and BANA enzyme analysis were measured at baseline, 1, 2, 6 and 12 weeks after treatment.

RESULTSStatistically significant decrease (P < 0.05) in SBI, BANA test and PLI occurred in both treatment groups at all time intervals compared to baseline. PD had a decreasing tendency in both groups, but only metronidazole group reached statistically significant level (P < 0.05) at 2 and 6 week intervals compared to baseline. None of the treatment modalities produced any side effects on the implant and peri-implant tissues.

CONCLUSIONSBoth 25% metronidazol gel and mechanical cleaning using ultrasonic carbon fiber tip can be safely and effectively used in the treatment of peri-implant diseases.

Adult ; Anti-Infective Agents ; therapeutic use ; Carbon ; Dental Implants ; adverse effects ; microbiology ; Female ; Humans ; Male ; Metronidazole ; therapeutic use ; Middle Aged ; Periodontitis ; etiology ; therapy ; Time Factors ; Treatment Outcome ; Ultrasonics

Objective:To evaluate the anxiety and depression symptoms of burning mouth syndrome (BMS), and to explore risk factors to BMS.Method:In this case-control study,147 patients with BMS and 140 sex-and age-matched healthy volunteers were recruited.Three questionnaires were used to collect information of psychical and mental condition.The Self-Rating Anxiety Scale (SAS)and Self-Rating Depression Scale (SDS)were applied to evaluate symptoms of anxiety and depression.The scores of SAS and SDS were statistically analyzed by t-test.The risk factors of BMS were statistically analyzed by Chi-square test and logistic regression analysis.Result:The scores of SAS and SDS were higher in the patients with BMS than in the controls [SAS:(44.4 ±9.9)vs. (35.7 ±6.2);SDS:(48.1 ±11.6)vs.(37.5 ±8.9)].The risk factors of BMS included ischemic stroke (OR =4.46,95%CI:1.87 -10.95),low level of education (OR =1.91,95%CI:1.04 -3.49),anxiety symptom (OR =8.12,95%CI:2.60 -25.37)and depression symptom (OR =2.57,95%CI:1.26 -5.27).Conclusion:BMS is a multi-factorial disease.It indicates that ischemic stroke,lower level of education,anxiety symptom and depression symptom are the risk factors of BMS.A positive association could be established between psychological alterations and BMS.According to these findings it can be assumed that mental factors should be taking into account in the etiologyof BMS.It should be advocated to treat BMS patients by psychotherapy.