Objective To explore the application of BCG polysaccharide nucleic acid injection in the treatment of skin diseases.Methods Selected in June 2015 to August 2016 period, in our hospital for skin disease treatment of 200 patients. According to the type of skin disease is divided into chronic eczema, chronic urticaria, alopecia areata and flat warts four groups, each group contains 50 patients. And then each group of patients were randomly divided into two groups, one group as a control group, a group as the observation group, each group of 25 cases. The control group was treated with traditional drug therapy, and the observation group needed to increase the use of BCG polysaccharide nucleic acid injection. The treatment period is for three months. To observe and compare the treatment effect of the control group and the experimental group after three months, that is, to observe and compare patients with chronic eczema, chronic urticaria, alopecia areata and flat warts of the four different types of skin diseases after three months of treatment effect. Results In the patients with chronic eczema, the effective rate of treatment was 96.0％ in the observation group and 68.0％ in the control group. The effective rate of the treatment group was significantly higher than that of the control group (P<0.05). The effective rate was 88.0％ in the observation group and 60.0％ in the control group. The effective rate of the treatment group was significantly higher than that of the control group (P<0.05). In the patients with alopecia areata, The effective rate of treatment was 84.0％ in the observation group and 72.0％ in the control group. The effective rate of the treatment group was significantly higher than that of the control group (P<0.05). In the patients with flat warts, The effective rate was 92.0％ and the effective rate was 68.0％ in the control group. The effective rate of the treatment group was significantly higher than that of the control group (P<0.05). In the different types of skin diseases, the effective rate of treatment was obvious Higher than the control group, the treatment effect was significantly better than the control group (P<0.05). Conclusion For patients with skin diseases using BCG polysaccharide nucleic acid injection for treatment, compared to the traditional drug treatment better. For the different types of skin diseases, the use of BCG polysaccharide nucleic acid injection for treatment can get the best therapeutic effect, so BCG polysaccharide nucleic acid injection in different types of skin disease clinical treatment is a worthy of use and Its promotion of the treatment.

Objective To investigate clinical efficacy of the NB-UVB phototherapy combined with calcipotriol ointment and halometasone cream in the treatment of psoriasis.Methods 90 patients with psoriasis were selected and randomly divided into control group and observation group with 45 cases of patients.In both two groups,calcipotriol ointment,1 time/d,were used combined with halometasone cream,1 time/d,with a total of 4 weeks.On the basis of these,patients of observation group were added NB-UVB phototherapy (Germany Waldmann7001K ultraviolet light therapy device),1 time every other day with starting dose of 0.5J/cm2,each increment of 0.1J/cm2,for treatment of 15 times.Before and after treatment in patients of two groups,PASI score and clinical efficacy were observed.Visual analogue scale (VAS) were was used to observe itching skin lesions before and after treatment.By using Dermatology Life Quality Index (DLQI),qualities of life in two groups of patients before and after treatment were evaluated.observe two patients before and after treatment expression levels of serum IL-17A,IL-22 and IL-1βwere also observed in patients of the two groups.Results The total efficiency of the observation group was 88.89％,which of the control group was 80.00％,the clinical efficacy of the observation group which was higher than that of the control group,and the difference was statistically significant (x2 =5.23,P ＜ 0.05).Before treatment,the difference of PASI,VAS score and DLQI in the two groups of patients were not statistically significant (P ＞ 0.05).After treatment,scores in the two groups of patients were significantly decreased,and the degree of decrease in the observation group was higher than the control group,the difference was significant (P ＜ 0.05).Before treatment,the differences in serum IL -17A,IL-22 and IL-1β expression levels of both two groups were not statistically significant (P ＞0.05).After treatment,these expression levels of the two groups of patients decreased significantly,and the decreased of observation group was more significantly than that of the control group (P ＜ 0.05).Conclusion NB-UVB phototherapy combined with calcipotriol ointment and halometasone cream in treatment of psoriasis vulgaris patients can significantly improve patients' skin lesions,and can improve patients' quality of life score,which is worthy of promotion.

Objective: To screen out suspected risk factors associated with neurosis, such as personality dis-order, life events, parental rearing behavior, and to explore degree of their associations. Methods: A case-control study was carried out among 100 cases with neurosis and 200 controls without mental disorder, matched by gender and age (+3 years) . The Life Events Scale (LES), Parental Rearing Style Questionnaire (EMBU), Personali-ty Diagnostic Questionnaire (PDQ-4) were self-reported by the subjects. Results: Single factor analysis showed that there were statistical differences (P <0.05) between case and control groups in negative life event (22.5 vs. 2.5), paternal rejection [(40.4±14.1) vs.(35.4±7.9)], paternal overprotection [(29.1±7.5)vs.(28.2±5.6)], maternal rejection rearing behavior [(40.4±13.7)vs.(36.8±8.5)], and overall personality disorder [(29.8±14.1)vs.(17.1±13.0)] . Using non-conditional logistic regression analysis, the potential protective factor was positive events (OR=0.92, 95% CI:0.87-0.98), and the potential risk factors included negative live events (OR=1.06, 95% CI:1.04～1.08) and overall personality disorder (OR=4.84, 95% CI: 2.24～10.49) . Conclusion: Positive life event may be a protective factor for neurosis, while negative life e-vent and personality disorder may be risk factors.

ObjectiveToinvestigatethekidneyyangdeficiencyconstitutionandhypothalamus-pituitary-adrenal ( HPA) axis dysfunction in Lewis rats .Method Two kidney yang deficiency models were established by subcutaneous injection of hydrocortisone and by adrenalectomy to induce hypothalamic -pituitary-adrenal ( HPA) axis dysfunction in Lewis rats.Wistar rats were used as control and compared with the two types of Lewis rat models of kidney yang deficiency .The degree of kidney yang deficiency of the Lewis rats was evaluated by examination and detection of the general signs , behavior , and neuroendocrine function , and so on .Result Compared with the normal Wistar rats , the body weight of Lewis rats was significantly higher than that of Wistar rats at the same age .The body temperature , urine volume and grip strength were significantly lower than those of Wistar rats ( P<0.01 for all ) .The memory ability of the Lewis rats was slightly decreased.The liver, kidney and adrenal indexes were significantly decreased in the Lewis rats (P<0.01).The levels of serum ACTH, CRH, cGMP, Cort and urine 17OHCS were significantly decreased (P<0.01).Conclusion A very slight deficiency of adrenal cortex function of Lewis rats is caused by genetic inheritance , and Lewis rats have the constitution of congenital kidney yang deficiency ( criticality or prophase of kidney yang deficiency ) .

OBJECTIVE To mine adverse drug event （ADE） signals of lacosamide， and to provide references for clinically safe drug use. METHODS ADE data for lacosamide reported to the United States FDA adverse event reporting system from January 1， 2009， to December 31， 2022， were collected. Data mining was conducted using the reporting odds ratio method and Bayesian confidence propagation neural network method. Classification statistics were performed using the system organ class （SOC） and preferred terms （PT） from ADE terminology set of Medical Dictionary for Regulatory Activities （Version 25.0）. RESULTS A total of 21 360 lacosamide ADE reports were received， identifying 203 ADE signals across 24 SOCs， with 19 signals not included in the drug’s instruction. The top five PTs ranked by occurrence frequency were medication overdose， technical errors during device use， product use issues， intentional product misuse， and therapy discontinuation. The top five PTs ranked by signal strength were changes in seizure presentation type， congenital hypoplasia of depressor anguli oris muscle， multidrug resistance， brain surgery， and vagus nerve stimulator implantation. ADEs not recorded in the drug instruction included congenital hypoplasia of depressor anguli oris muscle， multidrug resistance， mitochondrial DNA mutation， dissociative identity disorder， and congenital auricular anomaly. CONCLUSIONS For lacosamide-induced ADEs that occur frequently and are already listed in the drug’s instructions， such as bradycardia and atrioventricular block， the clinical application should be careful and attentive， adjusting the dosage timely according to the patient’s condition to avoid severe ADEs. Newly discovered suspect ADEs， such as congenital hypoplasia of depressor anguli oris muscle， mitochondrial DNA mutation， overmature infant， dissociative identity disorder， pigmenturia， behavioral disorders， and dissociative disorders， should be vigilantly recognized to ensure the safety of drug use.