1.Progress on economic evaluation of pneumococcal vaccine
Yuekun TANG ; Xiang GUO ; Xiaoying MA ; Hongli JIANG ; Yihan LU ; Zhuoying HUANG ; Jing QIU ; Jia REN ; Xiaodong SUN
Chinese Journal of Preventive Medicine 2021;55(7):896-902
Review the literature on the economic evaluation of PCV-10, PCV-13 and PPSV-23 for providing references for decision-making and research in China. A total of 17 literatures were included, and the basic information to descriptive characteristics, methodology, modeling and the results were extracted. The 14 studies adopted Markov model, 2 studies adopted decision tree model and 1 study adopted probabilistic model. The cost including vaccine price and administration costs, direct medical expenses and indirect lost. All the 17 studies use QALY as the outcome, some studies also use LYG as the outcome. 9 of 13 studies (69.2%) involving people over the age of 50 concluded that pneumococcal vaccination was cost-effective. To provide effective references for decision-makers, China should collect the relevant epidemiological parameters, vaccine effect of pneumococcal disease in the Chinese population and carry out the economic evaluation of pneumococcal vaccination.
2.Progress on economic evaluation of pneumococcal vaccine
Yuekun TANG ; Xiang GUO ; Xiaoying MA ; Hongli JIANG ; Yihan LU ; Zhuoying HUANG ; Jing QIU ; Jia REN ; Xiaodong SUN
Chinese Journal of Preventive Medicine 2021;55(7):896-902
Review the literature on the economic evaluation of PCV-10, PCV-13 and PPSV-23 for providing references for decision-making and research in China. A total of 17 literatures were included, and the basic information to descriptive characteristics, methodology, modeling and the results were extracted. The 14 studies adopted Markov model, 2 studies adopted decision tree model and 1 study adopted probabilistic model. The cost including vaccine price and administration costs, direct medical expenses and indirect lost. All the 17 studies use QALY as the outcome, some studies also use LYG as the outcome. 9 of 13 studies (69.2%) involving people over the age of 50 concluded that pneumococcal vaccination was cost-effective. To provide effective references for decision-makers, China should collect the relevant epidemiological parameters, vaccine effect of pneumococcal disease in the Chinese population and carry out the economic evaluation of pneumococcal vaccination.
3.Role of post-translational modification of basic leucine zipper transcription factors in response to abiotic stresses in plants.
Ying LI ; Weidi ZHAO ; Jinghua YANG ; Jiaqi LI ; Songyang HAN ; Yuekun REN ; Changhong GUO
Chinese Journal of Biotechnology 2024;40(1):53-62
Abiotic stresses substantially affect the growth and development of plants. Plants have evolved multiple strategies to cope with the environmental stresses, among which transcription factors play an important role in regulating the tolerance to abiotic stresses. Basic leucine zipper transcription factors (bZIP) are one of the largest gene families. The stability and activity of bZIP transcription factors could be regulated by different post-translational modifications (PTMs) in response to various intracellular or extracellular stresses. This paper introduces the structural feature and classification of bZIP transcription factors, followed by summarizing the PTMs of bZIP transcription factors, such as phosphorylation, ubiquitination and small ubiquitin-like modifier (SUMO) modification, in response to abiotic stresses. In addition, future perspectives were prospected, which may facilitate cultivating excellent stress-resistant crop varieties by regulating the PTMs of bZIP transcription factors.
Basic-Leucine Zipper Transcription Factors/genetics*
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Protein Processing, Post-Translational
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Phosphorylation
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Transcription Factors/genetics*
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Stress, Physiological/genetics*