Objective:To explore whether the combination therapy of epinephrine and methylprednisolone during intrahospital cardiopulmonary resuscitation (CPR) could increase the rate of restoration of spontaneous circulation (ROSC) and improve the survival rate after CPR .Methods:One hundred patients with cardiac arrest were randomly recruited and allocated into therapy group(n=50) and control group(n=50) .Standard dose of epinephrine and methylprednisolone were applied in therapy group , while standard dose of methylprednisolone was applied in control group .The ROSC rate and post‐discharge survival rate of patients in both groups were observed .Results:The ROSC rate and post‐discharge survival rate in the therapy group were 62 .0% and 14 .0% ,respectively ,while that in the control group were 16 .0% and 4 .0% ,respectively .The differences between the two groups were statistically significant(P<0 .05) .Conclusions:Combination therapy of methylprednisolone and epinephrine during CPR could significantly improve the ROSC rate and post‐discharge survival rate .