This study was aimed to explore the influence of extreme environment changes on the lung immune function in rats. Artificial climate system was used to simulate six extreme weathers, which were the sudden temperature increase (ZS), sudden temperature drop (ZJ), continuous high temperature (CG), continuous low temperature (CD), high temperature and high humidity (GWGS), normal temperature and high humidity (CWGS). And then, the method of enzyme-linked immunosorbent assay (ELISA) was adopted to detect bronchoalveolar lavage fluid (BALF) and related immune substances in lung tissues. The results showed there was significant difference of ZJ on IL-10 (P<0.05). There were significant differences of CG, CD, GWGS, and CWGS on IL-6, INF-γ and sIgA (P<0.05). Contents of the GWGS group and CWGS group were higher than that of the CG group and CD group. There was very significant difference on IL-10 in the CD group (P<0.01). It was concluded that the extreme environment changes had different influence on body’s immune. And different intervention factors cause the body’s immune factors to response accordingly.

Lung cancer is the leading cause of cancer related mortality in the world,with more than 1 million deaths per year,accounting for about one fifth of all cancer deaths worldwide.Over the past years,lung cancer treatment has been based on surgery,radiation therapy,chemotherapy,targeted therapies,and immunotherapy,but the improvement is not very perfect.Therefore,it has become clear that additional therapeutic strategies are urgently required to provide an improved survival benefit for patients.In recent years,Hippo signaling pathway has become a popular direction in the field of cancer research.When the Hippo pathway is active,the core Hippo kinase,such as MST/MOB and LATS1/2,inhibit the two transcriptional co-activators,YAP/TAZ.And YAP/TAZ are phosphorylated and sequestered in the cytoplasm.Dysregulation of the Hippo pathway drives multiple aspects of lung tumor initiation and progression.Moreover,the potential value of this pathway is getting more and more prevalent in clinical application.In this review,we summarize the molecular mechanism and the core components,upstream or downstream targets of Hippo signaling pathway which contribute the formation of lung cancer and discuss the therapeutic potential of targeted strategies in lung cancer.Additionally,we highlight the prospect of research on Hippo signaling pathway in the future.