This study was aimed to investigate potential biomarkers in different traditional Chinese medicine (TCM) syndromes of angina pectoris of coronary heart disease (CHD) by using metabolomic technology,and to explore the objective law of different TCM syndromes of CHD.Endogenous metabolites in serum and urine from the healthy group,and patients with DHD angina pectoris patients of the syndrome of Qi deficiency and blood stasis,as well as the syndrome of Qi deficiency,blood stasis and phlegm turbidity were detected by the liquid chromatography-mass spectrometry (LC-MS).Metabolic profiles were analyzed by the principal component analysis (PCA) and the orthogonal partial least squares discriminant analysis (OPLS-DA).The results showed that in PCA,the healthy group,Qi deficiency and blood stasis group,as well as the Qi deficiency,blood stasis and phlegm turbidity group can be obviously distinguished.Potential biomarkers in the Qi deficiency and blood stasis syndrome contained aspartyl methionine and cysteine sulfinic acid.Potential biomarkers in the Qi deficiency,blood stasis and phlegm turbidity syndrome contained hippuric acid,amino glucose,fructosamine and triglyceride.The objective performance of Qi deficiency syndrome was the absence of biotin,lysyl tyrosine,phosphatidylglycerol and glycocholic acid.It was concluded that through the new metabolomic technology,different endogenous metabolites in the syndrome of Qi deficiency and blood stasis,as well as the syndrome of Qi deficiency,blood stasis and phlegm turbidity of patients with DHD angina pectoris were detected.It provided ideas for the clinical practice of prevention,diagnosis and treatment of different TCM syndromes.

Objective To investigate the level and impact factors of stigma in people living with stroke patients in community. Methods A total of 189 stroke patients in community were investigated by general information questionnaire, Stigma Scale for Chronic Illness, Medical Moping Questionnaire, Self-Rating Depression Scale and Social Support Rating Scale. Results The total score of stigma was (44.96± 16.71) points, score of self-stigma was (27.70±10.91) points, score of enacted-stigma was (17.26±7.00) points. Multiple regression analysis showed that stroke patients′ depression, avoiding coping, subjective support and activity of daily living were impact factors of stigma, which explained 57.5% of the variance. Conclusions Community nurses should pay attention to the stigma of stroke patients in community, especially focus on those with higher degree of depression and lower activity of daily living, guiding them to adopt positive coping strategies and enhance subjective support. Oriented by influencing factors, proper intervention should be provided to lower the level of stigma, promote psychosomatic rehabilitation.

Objective To evaluate the morbidity,clinical manifestation,risk factors and prognosis of diffuse large B-cell lymphoma(DLBCL)patients with central nerve system(CNS)infiltration.Methods Clinical data of DLBCL patients with CNS infiltration between Jan 2005 and Jan 2012 were reviewed.Results Among 168 DLBCL patients,11 patients(6.5 ％)had CNS infiltration.ECOG scores ≥ 2,elevated lactate dehydrogenase(LDH)＞ 2 times of normal range and the involvement of ≥ 2 extranodal sites were clinical risk factors associated with CNS inflitration(x2 =11.6,4.61,3.92,all P ＜ 0.005).Median survival time after CNS infiltration was 4.5 months.Conclusion DLBCL patients with CNS infiltration are not rare,the patients demonstrate significantly bad prognosis.

Adjuvants, Immunologic ; therapeutic use ; Astragalus Plant ; Child ; Child, Preschool ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Humans ; Infant ; Male ; Nucleic Acids ; therapeutic use ; Phytotherapy ; Pneumonia ; drug therapy ; immunology ; Recurrence ; Respiratory Tract Infections ; drug therapy ; immunology ; Tyrosine ; therapeutic use

Objective To explore the influence of QCC on the infection of orthopedic aseptic operation and healthcare workers in the operating room. Methods A total of 170 patients undergoing orthopedic aseptic operation from January 2015 to June 2015 were chosen as QCC group and 164 patients from June 2014 to December 2014 as control group. The wound infection rate,increased rate of WBC and temper-ature,the responsibility,initiative,problem solving skills,self-confidence,harmony,cohesion of doctors and nurses between two groups were recorded. Results The wound infection rate(2. 4%), increased rate of WBC(2. 4%) and temperature(1. 2%) in QCC group were signifi-cantly lower than those of control group(5. 5%,9. 1%,6. 7%). Moreover,the responsibility(4. 6 ± 0. 6) point,initiative(4. 4 ± 0. 3) point, problem solving skills(4. 1 ± 0. 8) point,self-confidence(4. 3 ± 0. 7) point,harmony(4. 8 ± 0. 9) point and cohesion (4. 2 ± 0. 4) point of doctors and nurses in QCC group were significantly higher than those of control group[(2.9±0.7) point,(2.3±0.5) point,(2.5±0.5) point,(2. 8 ± 0. 6) point,(3. 1 ± 0. 4) point,(1. 8 ± 0. 3) point,respectively)]. Conclusion QCC could effectively reduce the infection rate of orthopedic aseptic operation,and improve the overall quality of the participants health care workers in the operating room.

0.05).However,LVEF before revascularization had significant influence on mortality(P=0.004,95%CI=0.893~0.978).Conclusion The strategy of incomplete revascularization by percutaneous coronary intervention(PCI) did not show inferiority in terms of mortality compared with complete revascularization by PCI or CABG in patients with three-vessel disease while the level of pre-operational LVEF had significant influence on the mortality rate.

Objective: To improve the present method for casualty forecasting using the risk analysis theory. Methods: Empirical data were extracted from 11 urban aggressive combats during and after WW II, and the distribution of daily casualty was determined. Based on quantitative judgment model, several factors such as the number of soldiers, terrain, weather, general situation, suddenness, and combat efficacy were configured; Monte Carlo simulation was applied for simulation,and a forecasting model was setup with Microsoft Excel and Crystal Ball 2000 software for risk analysis of the simulation outcome. Results: The distribution of daily casualty during urban aggressive military action could be represented by normal distribution. With the values of the aforementioned factors, the result of 1000 tests showed that the mean daily casualty rate was 0. 42%, with the standard deviation being 0. 21%. Conclusion: Monte Carlo simulation is an effective means to improve the present casualty forecasting method.

OBJECTEVE:To probe into the difference of drug prices between used in hospital and retailed in market.METHODS:Analysis the different reasons of drug price from drug quality assurance system,pharmaceutical care,drug using structure system and function mechanism.RESULTS&CONCLUSION:It's rational that the drug prices used in hospital high_ er than in retailed market.It's pratical and realistic attitude to the fact that the same drug has different prices in the medical market.

Bc58 is a UV resistant wild type strain that has an ability to produce a sorrel pigment induced by L-tyrosine.The FT-IR spectra and chemical tests of its pigment are similar to that of the standard melanin(Sigma).By bioassay shows that the LC_(50) of a Bt formulation added with the melanin of Bc58 and exposed to UV for 5 h is 16.1?g/mL,which is similar to that of Bt formulation without treated with UV,however,it is almost double higher than that of Bt formulation exposed to UV without the melanin of Bc58.The result of SDS-PAGE indicates that the melanin of Bc58 can protect the insecticidal crystal proteins from degradation.It suggests that an excellent UV protective agent to the insecticidal crystal proteins of Bt formulation.

Astragalus Plant ; chemistry ; Drugs, Chinese Herbal ; pharmacology ; Genes, MHC Class I ; genetics ; HL-60 Cells ; Humans ; K562 Cells ; Killer Cells, Natural ; drug effects ; Leukemia ; genetics ; metabolism ; Polysaccharides ; pharmacology