1.Advances on the treatment of Hashimoto thyroiditis
Yue MA ; Renyi ZHOU ; Ping HAN
Chinese Journal of Practical Internal Medicine 2001;0(05):-
Hashimoto thyroiditis(HT) is the most common autoimmune thyroid disease,which can present as euthyroidism,hypothyroidism or hyperthyroidism.Currently,there are still disputes on the treatment of such diseases.This paper summarizes the researches on the HT treatment at home and abroad in recent years,introduces the latest developments of iodine restriction,thyroid hormone replacement therapy,systemic immune regulation therapy,local immune regulation therapy,statins and surgical treatment.It elaborates the international consensus on recommended iodine intake and the importance of the individualized principle of thyroid hormone replacement therapy.
3.A study on the test validity of squatting and rising load for evaluating university students' cardiac function.
Yong-Ping ZHOU ; Yue-Hong MO ; Xing-Jie HAO
Chinese Journal of Applied Physiology 2008;24(3):372-I
Exercise Test
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methods
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Heart
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physiology
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Heart Rate
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physiology
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Humans
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Lung
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physiology
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Male
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Oxygen Consumption
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physiology
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Physical Endurance
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physiology
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Predictive Value of Tests
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Students
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Universities
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Young Adult
6.Bioaccessibility of heavy metal in wild Artemisia annua and its health risk assessment.
Liang-yun ZHOU ; Hong YUE ; Xuan LI ; Ge MO ; Li-ping KANG ; Lan-ping GUO
China Journal of Chinese Materia Medica 2015;40(10):1904-1907
In this study, we investigate the bioaccessibility of heavy metals (Cu, Pb, As, Cd and Hg) in wild Artemisia annua and use target hazard quotients (THQ) proposed by US Environmental Protection Agency to assess the health risk under the heavy metal exposure. The results showed that the bioaccessibility of Cu, Pb, As, Cd and Hg in A. annua are 0.77, 0.66, 0.46, 0.68 and 0, respectively, and that the value of THQ for adults and children were 0.030 and 0.025 calculated by risk assessment model. The results indicated that the heavy metals in A. annua were not able to be completely absorbed by human body and that their contents were in a safe range. In this study, by combining the bioavailability of heavy metal and health risk assessment, we assessed the security of heavy metals of wild A. annua, which will provide reference for the standard of heavy metals for medicinal materials.
Artemisia annua
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chemistry
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metabolism
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Consumer Product Safety
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Drug Contamination
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Humans
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Metals, Heavy
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analysis
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metabolism
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Risk Assessment
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Soil Pollutants
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analysis
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metabolism
7.Investigation about the postoperative rehabilitation and the health knowledge of patients with arteriosclerosis obliterans in lower extremity
Jin ZHOU ; Ping YANG ; Changhong ZHOU ; Donghui LAN ; Yu PEI ; Yue JIA
Chinese Journal of Practical Nursing 2016;32(21):1601-1604
Objective To investigate the condition of exercise, medicine compliance and the rehabilitation of patients with arteriosclerosis obliterans (ASO) in lower extremity after the surgery, and also to study the influence of self-efficiency and social support to their rehabilitation. Methods The questionnaire survey was performed in 102 patients who had surgical or interventional therapy of arteriosclerosis obliterans in the lower extremity in our hospital, investigated the general information of the patients, their knowledge of postoperative rehabilitation, medicine compliance, exercise condition, general self-efficiency and social support. Results The postoperative time for the patients with arteriosclerosis obliterans was 2 to 22months, the knowledge rate for postoperative rehabilitation was 7.8%-46.1%.The Morisky score for the patients of taking medicine for the treatment of vascular disease was 2.0,and there was only 6 patients(5.9%)with good medicine compliance. There were 22 patients(21.0%) had completed the ambulation training according to the guidelines, and there were 25 patients(24.5%) had completed the Buerger training. The self-efficiency score of the patients was 2.78 ± 0.76, and the gross score of social support was 32.38 ± 7.89. Spearman correlation analysis shows that the Morisky score for the patients of taking medicine for the treatment of vascular disease was in positive correlation with self-efficiency (r=0.289, P=0.003), but in negative correlation with social support (r=–0.286, P=0.006). Conclusions Most of the patients with arteriosclerosis obliterans have poor medicine compliance, and do not do exercise as required by the guidelines. Patients with high self-efficiency demonstrates medicine noncompliance, however the enhancement of social support will help patients improve their medicine compliance.
8.A case-control study on the risk factors of leukemia in mining areas of rare-earth in South Jiangxi.
Lei WU ; Yue-Ping ZHOU ; Hong-Jing ZHONG
Chinese Journal of Epidemiology 2003;24(10):879-882
OBJECTIVEIn order to explore the correlation on radioactive contamination of lanthanon to leukemia, and provide clues for the causes and prevention of leukemia in mining areas of rare-earth elements.
METHODS1:1 matched case-control study was used. A total of 51 clinically confirmed leukemia cases, individually matched with controls from general population, were interviewed in mining areas of rare-earth in South Jiangxi from November to December, 2001. Data were analyzed, using conditional logistic regression.
RESULTSThe main risk factors would include frequently drinking water from river (OR = 5.543), distance from residence to rare-earth mine and years for living in the area (OR = 3.308), exposure to organophosphorus pesticide (OR = 3.014). Tea drinking habit appeared to be a protective factor.
CONCLUSIONSLeukemia seemed to be related to environmental pollution with rare-earth elements around the residential areas and organophosphorus pesticide exposure. The protective factor of tea drinking habit seemed to be unique in this study, which called for further studies.
Adolescent ; Adult ; Aged ; Case-Control Studies ; Child ; Child, Preschool ; Female ; Humans ; Insecticides ; toxicity ; Leukemia ; etiology ; Logistic Models ; Male ; Metals, Rare Earth ; toxicity ; Middle Aged ; Mining ; Organophosphorus Compounds ; Risk Factors ; Tea ; Water Pollutants, Chemical ; toxicity
9.Effect of SIRT6/NF-κB signal axis in delaying hematopoietic stem/progenitor cell senescence with ginsenoside Rg1.
Yue ZHOU ; Yan-long TANG ; Ya-ping WANG ; Jian-wei WANG ; Ji-chao DING
China Journal of Chinese Materia Medica 2015;40(3):511-515
OBJECTIVETo investigate the effect of SIRT6/NF-κB signal axis in delaying hematopoietic stem/progenitor cell senescence with ginsenoside Rg1, in order to provide theatrical and experimental basis for looking for methods for delaying HSC senescence.
METHODSca-1 + HSC/HPC was isolated by magnetic cell sorting (MACS) and divided into five groups: the normal control group, the aging group, the positive control group, the Rg1 anti-senescence group, and the Rg1-treated group. Senescence-associated β-galactosidase (SA-β-Gal) staining, cell cycle analysis and hemopoietic progenitor cell mix (CFU-Mix) were adopted to determine the effect Rg1 in delaying or treating Sca-1 + HSC/HPC senescence biology. The mRNA and protein of senescence regulation molecules SIRT6 and NF-KB were examined by realtime fluorescence quantitative PCR (FQ-PCR) and western blotting.
RESULTCompared with the senescence group, the Rg1 anti-senescence group and the Rg1-treated group showed lower percentage in SA-β-Gal-stained positive cells, decreased cell proportion in G1 phase, increased number of CFU-Mix, up-regulated in SIRT6 mRNA and protein expression, down-regulation in NF-KB mRNA and protein expression. The Rg1 anti-senescence group showed more evident changes in indexes than the Rg1-treated group.
CONCLUSIONRg, may inhibit Sca-1 + HSC/HPC senescence induced by t-BHP by regulating SIRT6/NF-KB signal path.
Animals ; Antigens, Ly ; analysis ; Cellular Senescence ; drug effects ; Female ; Ginsenosides ; pharmacology ; Hematopoietic Stem Cells ; drug effects ; Male ; Membrane Proteins ; analysis ; Mice ; Mice, Inbred C57BL ; NF-kappa B ; physiology ; Signal Transduction ; physiology ; Sirtuins ; physiology
10.Role of Nuclear Factor kappa B in Neointima Formation after Balloon-Injured Rat Artery
jun, ZHOU ; guo-ping, LU ; chun-fang, WU ; zhen-yue, CHEN
Journal of Shanghai Jiaotong University(Medical Science) 2006;0(08):-
Objective We examined the in vivo effect of the antisense or/and decoy oligonucleotide of nuclear factor-?appa B (NF-?B) on balloon-injured smooth muscle cell proliferation and MMP-9 in the carotid artery of rats. Methods Sprague-Dawley rats underwent balloon-dilation injury of the left carotid artery. Rats were divided into 7 groups(n=18) and each group included 6 time points (6 h and 1,3,5,7,14 d)(n=3). Results The mean intima/media ratio increased significantly in sense group、scramble group and model group and reached the maximum at 7 d after rat injured carotid artery, compared with normal group, antisense group, decoy group and decoy plus antisense group(P