Child ; Child, Preschool ; Female ; Follicle Stimulating Hormone ; blood ; Gonadotropins ; blood ; Humans ; Infant ; Infant, Newborn ; Male ; Sex Factors ; Time Factors

Frailty,a multisystem syndrome in which the decrease of physiological reserve leads to the decrease of anti-stress ability,is highly prevalent among the elderly and is closely associated with ad-verse outcomes in surgical patients.Therefore,it is necessary for anesthesiologists to evaluate frailty during perioperative period.However,how to quantify frailty quickly,accurately,and objectively remains a chal-lenge.As the importance of muscle changes in the pathophysiological changes of frailty has been gradually revealed,bedside muscle ultrasound has attracted widespread attention in the assessment of weakness.This article introduces the parameters of bedside muscle ultrasoundand,the selection of parameters,and muscles for the assessment of frailty in elderly patients,which is expected to provide reference for anesthesiologists in assessing frailty during the perioperative period.

Objective To explore the best puncture method when applying scalp acupuncture to newborn's femoral vein blood drawing, so that we may raise the achievement ratio. Methods A total of 360 blood specimen collections of newborn nursery were selected. According to different puncture methods, they were randomly divided into two groups, straight puncture group (n = 180) and oblique puncture group (n = 180). The success rate, scathing conditions of local tissue, the conditions of hemolysis and clotting were compared and analyzed. Results There were significant differences between the two groups on success rate (P＜0.01). The success rate of oblique puncture group reached 94.4%. The scathing conditions of local tissue of the two groups were significant different (P＜0.05 ), but there were no significant differences between the conditions of hemolysis and clotting of the two groups (P = 0.822 ). Conclusions It is helpful to achieve high success rate, rich bloodstream and the adequate blood at one time applying scalp acupuncture to newborn's femoral vein blood drawing with oblique puncture. It also help to reduce the incidence of the scathing conditions of local tissue and it will reduce the amount of work of nurses and lighten sufferings of the newborns. It is suggested to choose oblique puncture method when applying scalp acupuncture to newborn's femoral vein blood drawing.

Animals ; Fatty Liver ; drug therapy ; metabolism ; prevention & control ; Liver ; metabolism ; Male ; Rats ; Rats, Sprague-Dawley ; Superoxide Dismutase ; metabolism ; Taurine ; therapeutic use

OBJECTIVETo review the current advances on the role of uncoupling protein (UCP) in the pathogenesis and progress of nonalcoholic fatty liver disease (NAFLD).

DATA SOURCESA comprehensive search of the PubMed literature without restriction on the publication date was carried out using keywords such as UCP and NAFLD.

STUDY SELECTIONArticles containing information related to NAFLD and UCP were selected and carefully analyzed.

RESULTSThe typical concepts, up-to-date findings, and existing controversies of UCP2 in NAFLD were summarized. Besides, the effect of a novel subtype of UCP (hepatocellular down regulated mitochondrial carrier protein, HDMCP) in NAFLD was also analyzed. Finally, the concept that any mitochondrial inner membrane carrier protein may have, more or less, the uncoupling ability was reinforced.

CONCLUSIONSConsidering the importance of NAFLD in clinics and UCP in energy metabolism, we believe that this review may raise research enthusiasm on the effect of UCP in NAFLD and provide a novel mechanism and therapeutic target for NAFLD.

Animals ; Fatty Acids, Nonesterified ; metabolism ; Fatty Liver ; etiology ; metabolism ; Humans ; Ion Channels ; physiology ; Mitochondrial Proteins ; analysis ; chemistry ; physiology ; Non-alcoholic Fatty Liver Disease ; Uncoupling Protein 2

OBJECTIVE: This study aims to investigate association between early recognizable minor physical abnormality (MPA) during childhood is associated with mental health problems in young adults. METHODS: In 1984, 169 preschool children in central Taiwan underwent a detailed physical examination for subtle abnormalities (MPA). Fourteen years later, the Brief Symptom Rating Scale (BSRS) and Chinese Health Questionnaire (CHQ) were used to measure specific psychiatric symptoms. RESULTS: There is an association between MPA during childhood and adult characterized with interpersonal sensitivity, anxiety, depression and paranoid mental health symptoms. CONCLUSION: The signs of childhood MPA can be easily identified and should be regarded as risk factors when predicting mental disorder. Mental health professionals should consider MPAs as important signs for possible development of emotional problems.
Adult ; Anxiety ; Asian Continental Ancestry Group ; Child, Preschool ; Depression ; Humans ; Mental Disorders ; Mental Health ; Physical Examination ; Pilot Projects* ; Surveys and Questionnaires ; Risk Factors ; Taiwan ; Young Adult

OBJECTIVE: This study aims to investigate association between early recognizable minor physical abnormality (MPA) during childhood is associated with mental health problems in young adults. METHODS: In 1984, 169 preschool children in central Taiwan underwent a detailed physical examination for subtle abnormalities (MPA). Fourteen years later, the Brief Symptom Rating Scale (BSRS) and Chinese Health Questionnaire (CHQ) were used to measure specific psychiatric symptoms. RESULTS: There is an association between MPA during childhood and adult characterized with interpersonal sensitivity, anxiety, depression and paranoid mental health symptoms. CONCLUSION: The signs of childhood MPA can be easily identified and should be regarded as risk factors when predicting mental disorder. Mental health professionals should consider MPAs as important signs for possible development of emotional problems.
Adult ; Anxiety ; Asian Continental Ancestry Group ; Child, Preschool ; Depression ; Humans ; Mental Disorders ; Mental Health ; Physical Examination ; Pilot Projects* ; Surveys and Questionnaires ; Risk Factors ; Taiwan ; Young Adult

OBJECTIVE Diabetic nephropathy (DN) has been one of the most common complications of diabetes and the leading cause of end-stage renal disease. Glomerular hyperfiltrationis central in earlystage of DN and leads to the progression of renal architectonic and functional abnormalities. Salvi?anolic acid A (SalA) has been proved to protect diabetic complications such as hepatic fibrosis and neuropathy. The present study was designed to investigate the effects of SalAon glomerular endothelial dysfunctionand diabetic nephropathy. METHODS Primary glomerular endothelial cells were subjected to assess permeability under injury of advanced glycation end-products (AGEs). AGEs-induced changes of RhoA/ROCK pathway and cytoskeleton rearrangement were assessed bywestern blotandimmunoflu?orescence. The beneficial effects of SalA on diabetic nephropathy were investigated in a rat model induced by high-fat and high-glucose diet combined with low dose of streptozocin (35 mg·kg- 1, ip). Renal function and architectonic changes were evaluated by biochemical assay and PAS staining. RESULTS SalA 3μMameliorated AGEs- induced glomerular endothelial permeability (P<0.05) and suppressed rearrangement of cytoskeleton through inhibiting AGE-RAGE-RhoA/ROCK pathway. SalA 1 mg · kg- 1 markedly reduced endothelium loss (P<0.01) and glomerular hyperfiltration (P<0.05) in diabetic kidney. Subsequently,SalA 1 mg·kg-1 suppressed glomerular hypertrophy and mesangial matrix expansion, eventually reduced 24 h-urinary albumin and ameliorated renal function by decreasing blood urine nitrogen (BUN), serum creatinine (Scr) and serum n-acetyl-β-d-glucosaminidase (NAG). AGEs-RAGE-Nox4-induced oxidative stress was suppressed by the treatment of SalA 1 mg·kg-1. CONCLUSION SalA ameliorated AGEs-induced glomerular endothelial hyperpermeability, and effec?tively protected against early-stage diabetic nephropathy by reducing hyperfiltration and alleviating renal structural deterioration through inhibiting AGEs and its downstream pathway. Thus, SalA might be a promising therapeutic agent for the treatment of diabetic nephropathy.

Objective To evaluate the clinical efficacy and safety of gabapentin combined with stellate ganglion block in the treatment of chro-nic tension-type headache.Methods One hundred and sixty-six pa-tients with chronic tension -type headache were randomly divided into experiment group ( n=83 ) and control group ( n=83 ) .All of the sub-jects received oral gabapentin at initial dose of 100-200 mg? d-1 , the dose could be adjusted gradually according to the therapeutic effect.Pa-tients in experiment group combined with stellate ganglion block, 2 times a week; patients in control group took eperisone 50 mg, orally, three times a day.The pain ( assessed before the treatment and every Friday during treatment period ) , depression and anxiety ( assessed before the treatment and every other Friday during treatment period) , quality of life assessment( assessed before and after the treatment ) of the two groups were observed.Results The pain scores were significantly lower after treatment ( P<0.01 ) , but there was no significant difference between the two groups ( P>0.05 ) .The increase of gabapentin in experiment group was obviously less than that in control group ( P<0.01).The de-pression and anxiety after treatment significantly reduced than that of before treatment (P<0.01);14 d after treatment, there was no significant difference between two groups (P>0.05);28 d after treatment, depression scores of patients in experiment group were significantly lower than that in control group (P<0.01), but there were no significant differences in anxiety between the two groups (P>0.05).Conclusion Patients with chronic tension-type headache took gabapentin combined with stellate ganglion block had better curative effect and compliance with less side effect.

Objective To study the promotion of premature infants' growth who received water bed pattern with bird's nest nursing with the aim of doing some help to the premature infants' clinical nursing.Methods 80 premature infants whose embryonic age were 31 to 34 weeks without serious complications after birth and the score of Apgar≥8 at birth were selected and all the cases were divided into experimental group(40cases) and control group(40 cases)at random. The infants of control group were put into incubator in naked,and they received the traditional nursing. The experimental group was given the water bed pattern with bird's nest nursing. The amount of formula sucked by infants themselves, the weight gain and the length of hospital stay were compared, then analyzed the nursing effect. Results There were significant differences between the two groups on the amount of formula and the weight gain at the 7 th and 14 th days( P ＜0. 05 ). The length of hospital stays were (15.1 ±0.9) d and( 19.2 ± 1.8 ) d, and the differences were statistically significant(P＜0. 05). Conclusions Water bed pattern with bird's nest nursing can obviously increase the amount of formula sucked by premature infants themselves and improve the weight gain. And it is helpful to accelerate the premature to return to normal and to shorten the hospital stay. The water bed pattern with bird's nest nursing has great clinical meanings for the promotion of premature infants' growth and improvement of the life quality.