Child ; Hemofiltration ; Humans ; Male ; Paraquat ; poisoning ; Poisoning ; therapy ; Treatment Outcome

To evaluate the items of critical values and alert limits of the test results , to optimize the critical values report procedure , to modify the laboratory information system ( LIS ) and the hospital information system ( HIS ) , the critical values monitoring platform was designed .Through the monitoring platform,the critical value report rate and critical value report timely rate could be calculated , so reduce medical risks and improve the level of hospital management .

Humans ; Humidity ; adverse effects ; standards ; Incubators, Infant ; Infant, Newborn ; Intensive Care Units, Neonatal ; Water Supply ; standards

Recently,studies have demonstrated that several signaling pathways including Wnt,Notch,and Hedgehog which are involved in the regulation of the stem cells are abnormally activated in lung cancer.They are closely associated with some properties of the lung cancer stem cells,such as high tumorigenic,high metastasis,drug resistance and so on.In addition,several studies have shown that the population of the lung cancer stem cells,which are resistant to radiotherapy and chemotherapy significantly,highly express drug resistance proteins.Therefore,how to target lung cancer stem cells and ultimately cure the disease is becoming a hotspot in the cancer targeted therapy.

Objective To evaluate the effect of a new schistosomiasis control strategy based on the infection source control in four-lake regions of Hubei Province. Methods The new strategy based on the infection source control included the safe water sup-ply,feces harmless treatment,replacing cattle with machine,captive livestock,chemotherapy,Oncomelania hupensis snail con-trol in susceptible areas,hardening ditches,etc,and the new control strategy was implemented for 7 years in 9 counties(cities or districts)of the four-lake regions. The schistosomiasis situations were investigated before and after the intervention of the new strat-egy. Results The coverage rates of feces harmless toilets(three format toilets),biogas digesters,and safe water supply were 42.00%,23.16% and 93.76%,respectively. The number of ditch hardening was 1 960;the area of eliminating snails was 1 378.42 hm2;the number of persons who received the health education was 3 524 818 accounting for 92.17%of the total popula-tion;the number of person-time of taking active protection measures was 516 636 963. The average annual decline rates of schisto-some infection were 24.42%and 38.38%in residents and cattle,respectively. The endemic villages decreased by 4.77%,the vil-lages with snails decreased by 7.05%,and the villages with snails accounted between 63.19%and 66.21%of the total endemic vil-lages. The area with snails decreased by 90.35%,and the advance schistosomiasis patients decreased by 5.55%,and the fatality rate of advanced schistosomiasis patients decreased by 1.24%. No acute schistosomiasis patients occurred. Type One and Two en-demic(heavy endemic)villages decreased to zero;Type Three endemic(moderate endemic)villages decreased by 10.22%;but Type Four endemic(mild endemic)villages increased by 66.38%;and Type Five endemic(no endemic for 5 years)villages de-creased by 0.22%. The standards of schistosomiasis transmission controlled have achieved on schedule. Conclusion The imple-mentation of the new schistosomiasis control strategy based on the infection source control in four-lake regions of Hubei Province can effectively control schistosomiasis.

Effect of S83143, a praziquantel derivative, and its phosphate salt S85009, sulfate salt S85010 and hydrochloride salt S85021 on different developmental stages of Schistosoma japonicum in mice were ob- served. When infected mice were treated with S83143 suspension at a single oral dose of 400 mg/kg or with 3 different salts of S83143 at a single intramuscular dose of 100 mg' ( S83143 base )/kg, the worm reduction rate was 69~87% in 2 h old schistosomula and 47~96% in 32~33 d old adult worms, respectively, but had no effect on 3 ~14 d schistosomula. The results showed that the susceptibility of different developmental stages of schistosome to S83143 was similar to that of praziquantel.The acute LD50 of ig S83143 suspension was more than 10g/kg, while ED50 was 352?65 mg/kg. With im S85010 solution, the LD50 and ED50 were 176?14 and 66?10 mg/kg respectively. Therefore, the therapeutic index of S83143 was over 28, which was higher than 2.67 of S8S010.

Objective To explore the distribution of high-arsenic water in Shaanxi Province in order to provide theoretical basis for the control of arsenism.Methods The contents of arsenic of 4042 water sampled from 1898 nature villages in 12 counties were assessed using semi-quantitative reagent-knit,and the water samples of Shanyang County,the targeted area,was quantified using quantitative atomic fluorescent speemetry.Results The contents of arsenic of 6 water samples in 2 villages exceeded 0.05 mg/L,accounting for 0.15%(6/4042),were 0.46,0.53,0.63,0.69,0.74,1.53 mg/L,respestively,and located in Shanyang County.A crowd of 1146 exposed to hish asenic water.among whom 555 were children.Conclusions Arsenic in drink water in Shanyang County in Shaanxi Province is higher than the standard,to which a large number of people are exposed,water-improving and defluoridotion must be carried out as soon as possible,reduces harm of high arsenic.

Female ; Humans ; Male ; Sepsis ; complications ; Wernicke Encephalopathy ; diagnosis

Objective To investigate the MRI features of urethral sphincter in female with stress urinary incontinence(SUI) by the study of the indexes of the thickness of middle urethral sphincter, the function urethral length and bladder neck funnel . Methods Forty patients of female patients diagnosed as SUI by clinical were retrospectively as SUI group, and 40 asymptomatic female volunteers were recruited as reference group. All of the subjects were tested by pelvic MRI scanning both in static status and in the condition of Valsalva. The thickness of middle urinary sphincter was measured in the horizontal axis plane. In the midsagittal plane, the function urethral length was measured from the internal orifice to perineal fascia. The bladder neck funnel whether exist was observed from the midsagittal plane. For the comparison of the urinary sphincter thickness and urethral length of the two groups, independent sample t test was adopted. For urethral length in static status and under the condition of Valsalva, paired t test was done. For comparison of positive rate of the bladder neck funnel, Chi?squared test has been done. Results The value of the middle urinary sphincter thickness in the groups of SUI and reference were (2.23±0.68) mm and (2.69± 0.75) mm, respectively. Thus the differences of the two groups had statistical significance (t=-2.839, P<0.01 ). In the static status, the urethral length in SUI and reference group were (2.72±0.51) cm and (2.94± 0.34) cm respectively, wheras in Valsalva condition, the value were (2.33 ± 0.49) cm and (2.43 ± 0.43) cm respectively. The differences of the two groups had statistical significance in static status (t=-2.322, P=0.023), wheras there had no statistical significance in the two groups in Valsalva condition (t=-1.049,P=0.297). For SUI and reference group, both in static status and Valsalva condition, the difference of function urethral length had statistical significance (P< 0.01). The positive rate of bladder neck funnel for SUI was 72.5% (29/40), and for reference was 22.5% (9/40), the difference of the two groups had statistical significance(χ2=20.050, P<0.01). Conclusion For female SUI patients, urinary sphincter muscle is much thinner, function urethral length is much shorter and has higher positive rate of bladder neck funnel.

Objective To investigate the dynamic changes in each radical line of pelvic floor levator hiatus in female with stress urinary incontinence(SUI). Methods A retrospective analysis of MR images was performed in 30 female patients with clinically diagnosed SUI and 30 asymptomatic female volunteers recruited as reference group. All of the subjects underwent pelvic MRI scanning both in static statusand Valsalva maneuver, respectively, Valsalva was performed by attempt to forcibly urinate while holding her breath, respectively. Area of pelvic diaphragm hiatus (LHA), ntero-posterior length (LHL) and tmixmum width (LHW) were measured in horizontal axis plane of the obtained images.H line distance was measured in the midsagittal plane. Independent sample t test was performed to compare the difference in LHA, LHL and LHW between two groups. Paired t test was used to compare difference in LHA, LHL and LHW between two groups in static status and Valsalva maneuver, respectively. Results In static status, the values in LHA, LHL, LHW and H line distance for SUI groups were(28.7±19.3) cm2, (7.1±2.2) cm, (4.7± 1.6 ) cm and (5.7±1.1) cm, respectively. The parameters for the reference group were(13.1±3.7)cm2, (5.3± 0.8) cm, (3.4 ± 0.5) cm and (5.7 ± 0.9) cm, respectively. The difference in LHA, LHL, LHW between two groups was statistically significant (t=4.33, 4.36, 4.23, and P<0.01 for all indexes), whereas the difference in H line distance between two groups was no statistically significanct because of P> 0.05. In Valsalva
maneuver, LHA, LHL, LHW and H line distance were (40.0±26.0) cm2, (8.0±2.3) cm, (6.0±2.5) cm and (6.1± 1.5)cm for SUI group, and were (16.2±6.2) cm2,(5.5±1.0) cm, (3.6±0.8) cm and (6.0±1.0) cm for the reference group, respectively. The difference in LHA, LHL and LHW between two groups was statistically significant, (t=4.88, 5.36, 4.91 respectively, and P<0.01), whereas the differencein H value between two groups was no statistically significant (P< 0.05). For SUI group , the difference of LHA, LHL and LHW between static status and Valsalva maneuver had statistically significant with P<0.01. For reference group, the difference of LHA and LHL between static status and Valsalva maneuver had statistically significant(P<0.05). Conclusion Dynamic and static pelvic MRI can evaluate the morphology and variation of pelvic floor levator hiatus much intuitively and accurately. pelvic floor levator hiatus becomes enlarged in female with SUI.