Objective To investigate the effect of self-management program on low vision patients and the role of intrinsic motivation.Methods A total of 160 low vision patients were assigned into 2 groups by random digits table method with 80 cases each.The control group was given routine doctor's advice and health education,and the observation group was given a self-management program guided by well trained medical personnel on the basis of the control group.The General Self-efficacy Scale (GSS) and Chinese-version Low Vision Quality Of Life questionnaire (CLVQOL) was conducted before and after intervention.The patients' intrinsic motivation also was evaluated by Intrinsic Motivation Inventory (IMI) after intervention.Results The total score and scores of interest/fun,inner selectivity,subjective ability and stress/strain dimensions of IMI were (62.25±3.74),(18.43 ±3.67),(16.13 ± 1.53),(16.05 ±7.34),(11.64 ±2.74)points、in observation group and(50.24±4.32),(13.53±2.78),(13.67±1.75),(13.52±2.42),(9.52±1.77) points in control group,and there were significant differences (t=5.813-18.800,P＜ 0.05).The scores of GSS and CLVQOL in observation group after intervention were (27.49±3.41),(64.30±7.04) points,which were higher than those in control group:(16.54±2.25),(34.86±3.99) points,and there were significant differences (t=23.973,32.540,P ＜ 0.05).After intervention,the total score and interest/fun,inner selectivity,subjective ability and stress/strain dimensions of IMI in observation group were positively associated with the score of GSS (r=0.663-0.739,P ＜ 0.05).The total score of IMI was positively associated with the total score of CLVQOL (r=0.765,P ＜ 0.05).In addition,a positive association was observed between the total score and each dimension of CLVQOL and inner selectivity,subjective ability and stress/strain dimensions of the IMI (r=0.661-0.765,P ＜ 0.05).Conclusions A self-management program can improve low vision patients'self-efficacy and quality of life,intrinsic motivation is the important factor influencing the effect of selfmanagement program.

Objective To observe the protective effect of ulinastatin (UTI) on the intestinal barrier function of septic rats.Methods Septic rat model was established using Sprague-Dawley rats by cecal ligation and puncture (CLP) method.Thirty Sprague-Dawley rats were randomly divided into 3 groups (n =10 for each grop) : sham group, septic group and UTI group.All rats received intraperitoneal injections of 0.9％ saline (10 mL/kg) after and 8 h after surgery.In UTI group, UTI (10 × 104 U/kg in 10 mL/kg saline) was injected after and 8 h after surgery.Collect blood samples after 0, 8, 12 h after surgery to examine levels of procalcitonin (PCT), intestinal fatty acid binding protein (iFABP) and diamine oxidase (DAO) by enzyme-linked immunosorbent assay (ELISA) method.Rats were killed 12 h after surgery to collect intestine tissue samples.Pathological changes of intestine were observed under microscopy, and the expression of tight junction protein-1 (ZO-1) and occludin were analyzed by Western blot.Results In sham group, the mucosa structure was complete and the shape was normal, and villi stood neatly.In septic group, intestinal was expanded, intertinal mucosal was atrophic, villi were scanty.An inflammatory infiltrate with numerous nuetrophils was found in the mucosal.In UTI group, the level of severity was relatively slight.The relative optical density of Western blot images were decreased on ZO-1 and occludin in CLP and UTI groups, and decreased more in CLP group (F =43.15 and 52.23, P ＜ 0.05).At 0h after surgery, the plasma values of PCT, iFABP and DAO were similar in three groups (F =11.17, 22.45 and 13.58, P ＞ 0.05).At 8h and 12h after surgery, values of PCT, iFABP and DAO in septic and UTI groups were much higher than those in the sham group, and those in UTI group were also significantly higher than those in septic group (F8h=85.26, 44.59 and 101.47, F12h =59.44, 49.26 and 69.57, all P＜0.05).PCT, iFABP and DAO levels were first increased and then fell down in sham group, those in septic group were keeping increasing, and those in UTI group were first increased and then kept stable.Conclusion UTI shows protective effect to intestinal barrier function in rats with sepsis.