Objective To analyze the pathological significance of CK5 expression in primary cutaneous amyloidosis(PCA).Methods The expression of CK5 in superficial dermis of PCA group and the control group[lichen planus(LP),lupus erythematosus(LE)]were detected by CK5 monoclonal antibody.The infiltration densities of CD3-positive T lymphocytes and CD68-positive macrophages in superficial dermis of PCA and control group were measured respectively by immunohistochemical staining using anti-CD3 antibodies and anti-CD68 antibodies.The skin lesions of PCA and control groups were analyzed by immunofluorescence to detect whether CK5 was phagocytosed by macrophages in superficial dermis.Results Totally,39 cases of PCA all were CK5-positive.Some control cases were positive.The number of CD3-positive T lymphocytes and CD68-positive macrophages in 8 cases of PCA group was lower than that of control group.The result of immunofluorescence colocalization of monoclonal anti-CK5 antibodies and anti-CD68 antibodies in 5 cases of PCA lesions was negative;that in 2 cases of LE lesions were both positive,and that in 2 cases of LP lesions were both negative.Conclusion Amyloid protein may be derived from the basal keratinocytes after interface damage.The amyloid protein deposits may be related to the number decrease or the functional defect of macrophages.

To explore the relationship between eosinophilic hyperplasia lymphogranuloma (ELG) and nephrotic syndrome (NS). Methods 3 cases of ELG associated with NS were collected. The specimen of ELG and renal biopsy were confinned by pathological method, and clinical characteristic, therapeutic course and follow up were summarized. Results Two cases were ELG associated with minimal changes disease (MCD), another was early membranous nephropathy (MN) . ELG and NS were cured by prednisone therapy. Conclusion About 12% of ELG may be associated NS. The pathogenesis of ELG, MCD and MN are similar, and curative effect occured by same therapy. Suggesting that, they are identical allergic disease caused by one pathogeny.

usions CSP is not common and can be easily misdiagnosed and color ultrasound scan is important in its early diagnosis. UAE combined with MTX followed by curettage is an effective treatment of CSP.