1.Short-term and Long-term Efficacy of Arthroscopic Debridement,Lateral Patellar Decompression,and Rehabilitation Therapy for Osteoarthritis of the Knee Joint
Yubin WANG ; Huifang WANG ; Wenhui ZHU
Chinese Journal of Minimally Invasive Surgery 2005;0(08):-
Objective To study the short-term efficacy of arthroscopic debridement,lateral patellar decompression,and rehabilitation thearpy for osteoarthritis of the knee joint,and to discuss the long-term outcomes of the treatments.Methods A total of 85 cases of osteoarthritis that were diagnosed according to the clinical diagnostic criteria of ACR were enrolled in this study.The patients were randomly divided into groups A(39 cases) and B(46 cases) to underwent arthroscopic debridement and arthroscopic debridement combined with lateral patellar decompression respectivley.All the operations were performed by a same surgeon.Postoperative rehabilitation thearpies were carried out by one group of therapist.The Lysholm,HSS,and PPI scores were evaluated before the operation,as well as patellar tilt test and patellar gliding test.The examinations were repeated in 3 and 6 months respectivley after the surgery.Results In group A,the scores of Lysholm,HSS,and PPI determined at month 3 were significantly higher than those before the operation,but not changed markedly at month 6.Whereas,in group B,the scores kept being increased after the surgery.At month 3,the scores in group A were higher than those in group B,however,at month 6,the Lysholm score in group B was higher than that in group A.Conclusions Arthroscopic debridement and postoperative rehabilitation are effective for imroving the symtoms and knee function in patients with osteoarthritis and limited ROM of the patella.Combining with lateral patellar decompression,the treatments can achieve better outcomes in 6 months.
2.Correlation between Plasma Concentration of Nateglinide and Clinical Efficacy in Newly Diagnosed Type 2 Diabetes
Yubin ZHU ; Zheng ZHAO ; Yunxin LIU ; Jianhua MA
China Pharmacist 2017;20(1):94-95,98
Objective:To study the correlation between plasma concentration and clinical efficacy in newly diagnosed type 2 diabe-tes treated with nateglinide. Methods:On the basis of diet control and exercise, 73 cases of newly diagnosed type 2 diabetes received nateglinde therapy for 2 months. Adverse events were routinely monitored during the therapy. Fasting blood glucose(FBG), 2h post-prandial blood glucose(2h-PG), fasting C-peptide(F-CP), 2h C-peptide(P-CP) and glycosylated hemoglobin (HbA1c) were ob-served before and after the treatment. LC-MS was used to determine the plasma concentration of nateglinide on the last day of treat-ment. Results:FBG, 2h-PG, HbAlc and P-CP after the treatment had significant changes when compared with those before the treat-ment (P<0. 05). There was no significant difference in F-CP in spite of minor increase (P>0. 05). The difference in HbA1c and P-CP before and after the treatment both showed a significantly positive correlation with plasma concentration of nateglinide (P<0. 05). Conclusion:Nateglinide displays good clinical efficacy and safety in newly diagnosed type 2 diabetes, and its plasma concentration can be used to evaluate the pancreatic islets function and glucose-lowing effects.
3.Experimental study on inducing bone marrow stromal cells into Schwann-liked cells in vitro by modified method
Jianyun WANG ; Xiaolin LIU ; Jiakai ZHU ; Yubin DENG ; Jianping XIANG ; Fobao LI
Chinese Journal of Microsurgery 2000;0(03):-
Objective To search for a more efficient method to induce bone marrow stromal cells (BMSCs) into Schwann-liked cells (SLCs) in vitro. Methods On the base of the method which was used by Dezawa (it was looked as the traditional inducing method),some steps were modified,namely,to use all the reagents in half dose in the same time and two times intervally,this method was looked as the modified inducing method.After induced by the two methods,the cells morphologic characteristic,the positive ratio of immunocytochemical dye with anti-S-100 and anti-GFAP,the cells activity measured by MTT method and the DNA percentage in S period measured by flow cytometry were compared with each other respectively to evaluate the methods'effects. Results Compared with the traditional method,the cells induced by the modified method were more similar to the primary Schwann cells in morphology,more positive proportion in immunocytochemic dye with anti-S-100 and anti-GFAP,less damage in the activity and more percentage in S period. Conclusion The modified method had more advantages such as less damage on cells and more efficiency in inducing BMSCs into SLCs.
4.Arthroscopic repair of meniscal tears by FasT-Fix technique: a report of 36 cases
Yubin WANG ; Huifang WANG ; Wenhui ZHU ; Fang CUI ; Feng YUAN ; Liangyu LU ; Wenlin SUN
Chinese Journal of Trauma 2008;24(8):636-638
Objective To assess clinical outcomes of FasT-Fix technique in repair of meniscal injury under arthroscope. Methods A total of 36 cases (37 knees) of mensical tears were repaired with FasF-Fix technique. There were 26 males and 10 females, at mean age of 26 years (14-51 years). Eighteen meniscal tears were located in zone Ⅱ, 16 in zone Ⅲ and 3 in zone Ⅳ. The average length of the tear was 2.2 cm (1.0-3.0 cm). Results There were no any signs of early complications after sur gery. All cases were followed up For 6-26 months (mean 16 months). According to Lysholm scoring scale system ,the average score of operated knees was increased from preoperative 44.13+12.56 to postopera tive 80.24+12.67 (P<0.01). After operation, all the patients could move the knee joint at normal range, except for one case who had a limitation of 20 degree flexion, with no pain or interlocking symptom. All cases returned to original work and/or could continue sports game. Conclusion The FasT-Fix technique is a simple, safe and effective method for repair of properly selected meniscal tears.
5.Clinical characteristic of glenoid labral tears combined with rotator cuff tear
Yubin WANG ; Wenhui ZHU ; Liangyu LU ; Feng YUAN ; Huifang WANG ; Fang CUI
Chinese Journal of Trauma 2010;26(4):294-297
Objective To analyze the clinical characteristics of glenoid labral tear combined with rotator cuff tear so as to provide references for arthroscopic surgery.Methods A total of 50 patients (28 males and 22 females)at mean age of 45 years old(ranged from 30 to 58 years)were enrolled in the study.Clinical data including the mechanism and time of injury,symptoms,results of physical examination,X-ray and MRI were collected.Location and degree of rotator cuff and glenoid labral tears found during arthroscopic surgery were also recorded.There were 37 patients with anterior labral tears,eight with superior labrum tears and five with posterior labral tears.The rotator cuff tear was slight in 36 patients,moderate in 10 and severe in three.One patient had extra-large tear.Anterior part of rotator cuff was found torn in 21 patients,middle part in 16 and posterior part in 13.MRI of glenoid labral tears manifested disappearance of triangular appearance and enlarged joint capsule.MRI manifestations of rotator cuff tear were high signal in torn part and continuity loss.Results All patients were followed up for average 36 months(6-72 months),which showed satisfactory results.UCLA score was(15±3)points preoperatively and(32±3)points postoperatively(P<0.01).Conclusions More attention should be paid to glenoid labral tear to avoid misdiagnosis and delayed treatment,for it is usually combined with rotator cuff tear.Location of rotator cuff tear has some relation to the range of glenoid labral tear,ie,the larger range of glenoid labral tear may induce more posterior part of rotator cuff torn.
6. Changes of B cell-activating factor and a proliferation- inducing ligand in serum of children with Henöch-Schönlein purpura nephritis
Chinese Journal of Applied Clinical Pediatrics 2019;34(21):1627-1630
Objective:
To investigate the changes of B cell-activating factor (BAFF) and a proliferation- inducing ligand (APRIL) in serum of children with Henöch- Schönlein purpura nephritis (HSPN), and to explore their role in the pathogenesis of children HSPN.
Methods:
A total of 28 children with HSPN who were before treatment were selected in Department of Pediatrics Nephrology and Rheumatology, Shengjing Hospital of China Medical University from November 2017 to August 2018.Sixteen children with Henöch-Schönlein purpura were selected as HSP group, and 20 healthy children were selected as healthy control group.Followed the HSPN guideline to cure the patients for 6-8 weeks.The clinical data were collected.Serum levels of BAFF and APRIL were measured by adopting enzyme-linked immunosorbent assay (ELISA).
Results:
(1)Changes of serum BAFF level: the serum levels of BAFF in HSPN children were significantly lower than those in the HSP group and the healthy control group[ HSPN group (0.652±0.360) μg/L, HSP group (1.276±0.459) μg/L, healthy control group (1.285±0.299) μg/L,
7.Evaluation of Sterile Effect of Arthroscope Surgical Instruments Using Low-temperature Plasma Sterilizer
Juanli ZHU ; Mingxue ZHANG ; Yubin XING ; Ying NIE ; Huasheng WANG ; Feng SONG ; Li HE ; Lin CHEN ; Zheng ZHANG ; Yujie LIU
Chinese Journal of Nosocomiology 2006;0(05):-
OBJECTIVE To evaluate the feasibility and sterile effect of low-temperature plasma sterilizer produced by Chinese Academy of Sciences for the sterilization of arthroscope surgical instruments.METHODS To explore the cleaning,package,arrangement and sterile effect monitoring of instruments in the process of arthroscope sterilization using low-temperature plasma sterilizer.RESULTS In the sterilization process of arthroscope surgical instruments using low-temperature plasma sterilizer,the chemical indicators and indicating patch were discolored,the monitoring of bio-box and the sterilization monitoring of surgical instruments were all negative.CONCLUSIONS Using the low-temperature plasma sterilizer machine for the sterilization of endoscope surgical instruments can ensure the security of sterilization,make less injury of precise instruments,shorten the sterilization time,accelerate the surgical turnover,enhance the frequency of surgical instruments application,and increase the efficiency.
8. Retrospective clinical analysis of 34 cases with fibro-adipose vascular anomaly on the lower extremities
Dakan LIU ; Yubin GONG ; Song ZUO ; Xiaoshuang ZHU ; Changxian DONG
Chinese Journal of Plastic Surgery 2017;33(6):433-437
Objective:
To define a new subtype of vascular anomaly, named fibro-adipose vascular anomaly(FAVA)and to discuss the methods of diagnosis and treatment in order to decrease the misdiagnosis rate and improve the recovery rate.
Methods:
From Jan. 2011 to Dec. 2015, 34 cases with FAVA on the lower extremities received surgical treatment in our center. The clinical data were collected to summarize the imaging and pathological characteristics for diagnosis.
Results:
The misdiagnosis rate was 76.5%(26/34) in all these 34 patients. The cure rate was 100% after operation. The patients were followed-up for 1-3 years(average, 19 months) with normal function and no recurrence.
Conclusions
FAVA is usually misdiagnosed as hemangioma or vascular malformation. The disease should be well defined to help the diagnosis and treatment. Surgical excision is one of the optional treatments.
9.Developmental mechanism for calcific aortic valve disease
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery 2018;25(2):171-176
Calcific aortic valve disease has been the most common heart valve disorder in western world, accompanying with the increase of morbidity in our country year by year. Several molecules and mechanisms are involved in the progression of aortic valve calcification, which intensify the complexity of this pathological process. It is known that inflammation, a key factor in many diseases, has its own role in the development of aortic valve calcification. It has been demonstrated that inflammation, one of the most important participants in this disorder, which may accelerate the local lesions in aortic valve via promoting the expression of osteogenic differentiation of associated factors or decreasing the level of protective molecules. Dyslipidemia is a traditional risk factor of cardiovascular events. However, it may induce or enhance the inflammatory response whereby facilitates the calcific lesions in aortic valve. Recently, several researches have illustrated that non-coding RNAs, a stimulative factor in the progression of malignant tumor, might play a role in the development of aortic valve calcification. MiRNA and lncRNA, the non-coding RNAs which regulate the expression of genes involved in inflammatory and osteogenic differentiation, are undeniable regulators of aortic valve calcification.
10. Perioperative platelet transfusion in infantile with Kasabach-Merritt phenomenon insensitive to glucocorticoids
Xiaonan GUO ; Xiaoshuang ZHU ; Dakan LIU ; Yubin GONG ; Hongzhao LEI ; Changxian DONG
Chinese Journal of Plastic Surgery 2018;34(5):356-359
Objective:
To assess the safety and effectiveness of sufficient, short-term platelet (PLT) transfusion for the surgery preparation of the infantile patients with Kasabach-Merritt phenomenon, who were insensitive to glucocorticoids.
Methods:
The infantile cases were retrospectively analyzed during May 2011 to December 2016, who were clinically diagnosed as KMP and insensitive to glucocorticoids, received PLT transfusion and surgical resection. PLT transfusion in patients whose PLTC was less than 30×109/L, was 0.3 therapeutic dose(TD)/kg, and 0.2 TD/kg in PLTC≥30×109/L group. The maximum was 1 TD.Criteria of the PLT transrusion: 1 hour after the transfusion, the PLT count (PLTC) were tested and the corrected count increment of platelet (CCI) and practical platelet recovery (PPR) was calculated. PLTC ≥100×109/L, CCI>7.5×109/L and PPR>30% were defined as effective; while PLTC=(50-99)×109/L, CCI>7.5×109/L and PPR>30% as partial effective; PLTC<50×109/L, or CCI≤7.5×109/L, or PPR ≤30% were defined as ineffective. By reviewing the method and response of their PLT infusions, to figure out the most effective way in rising PLT, as a part of pre-operation treatment.
Results:
There were 46 cases in the research. Based on the PLTC, CCI and PPR 1 hour after PLT transfusion, there were 44 effective transfusion, 2 patients with partial effectiveness, and no ineffective case. There was no allergic or heart failure happened in any cases. No critical potential complications of PLT transfusion occurred, including fluid and iron overload, alloimmunization to human leukocyte antigen and/or PLT antigen.
Conclusions
Pre-operative sufficient and short-term PLT infusions are more effective than low dose and long-term ones. They can create a more optimistic opportunity for surgical resections.