1.EFFECTS AND MECHANISM OF SFPS ON RBC IMMUNE ENHANCEMENT OF P_(388) MICE
Yubin JI ; Qi KONG ; Weidong YANG
Chinese Journal of Marine Drugs 1994;0(02):-
In this paper,the effects of SFPS on red blood cell immune function of P388mice is presented. The results suggest that SFPS' enhancing the immune function of red blood cells of P388 mice may be related to decreasing the content of LPO of red blood cell membranes inhibiting the formation of HMP by protein of red blood cell membranes and systolic protein,increasing the sealing degree of red bold cell menbranes and the content of sialic acid and enhancing the activities of SOD, CAT, and Na+, K+-ATPase of red blood cell membranes.
2.Effect of sea-algae polysaccharide to tumor cell membrane fluidity
Yubin JI ; Shiyong GAO ; Qi KONG ;
Chinese Traditional and Herbal Drugs 1994;0(05):-
Object To study the antitumor mechanism of sea algae polysaccharide (SP). Methods The membrane fluidity of the S 180 and H 22 mice was observed by DPH fluorescent probe method. Results SP could increase the membrance fluidity of the S 180 and decrease that of the H 22 . Conclusion SP showed the antitumor effect through returning the tumor cell membrance fluidity to the normal one.
3.Effect of Haimidin on lipid fluidity in erythrocyte membrane and DNA content in normal and H_(22) tumor bearing mice
Yubin JI ; Xiujuan ZHANG ; Qi KONG ; Shiyong GAO ; Baofeng YANG ;
Chinese Traditional and Herbal Drugs 1994;0(08):-
Object To study the effect of Haimidin(HMD) on erythrocyte membrane of H 22 ascites tumor bearing mice and DNA synthesis in human gastric tumor cell Methods By fluorescence spectrophotometry and laser scanning confocal microscopy Results HMD can lower erythrocyte microviscosity and elevate membrane lipid fluidity of H 22 ascite tumor bearing mice It also reduced DNA fluorescent intensity and DNA content of gastric tumor cells in vitro Conclusion HMD can improve blood circulation of tumor bearing mice, enhance immune adherence of erythrocyte on tumor cells and displays its antitumor activity by interferring DNA synthesis of tumor cells
4.The Consumption, Perception, and Sensory Evaluation of Soy M
Seoli CHOI ; Jieun KIM ; Yubin KONG ; Junghee PARK ; Hongmie LEE
Journal of the Korean Dietetic Association 2022;28(4):267-280
The purpose of this study was to investigate the consumption status and perception of soy meat among university students and to compare their sensory evaluations of commercial meatballs and soy meatballs. The subjects were students at a university who were grouped into those majoring in food and nutrition and those not majoring in the subject. The results of the two groups were compared. The main sources through which the students became aware of meat analogs were examined. The food and nutrition major students were about three times more likely to learn about meat analogs through ‘education’, and those not majoring in the subject were about four times more likely to learn about them from the social media (P<0.01). The most common reason for having tried soy meat was 'curiosity' and that for not eating it was ‘no opportunity’. Without significant differences between groups, the most common answer for questions relating to the product that they had eaten was ‘Ramen flakes’ (30.5%) and the most common answer for the routes for eating the product was in the order of: ‘restaurants’ (36.6%)>school lunches (24.9%)>large and medium-sized supermarkets (22.8%). The most common answer to the question inviting suggestions on ‘improvement points to promote the consumption of soy meat’ was ‘taste’(19.2%), followed by ‘product promotion’ and ‘reasonable price’. About half of the subjects failed to differentiate the soy meatballs from regular meatballs before the sensory test and 21.3% after that. The difference in the sensory test scores of the two types of meatballs with respect to ‘texture’ was significantly higher for the major students than for the non-major students (P<0.05). These results could provide basic information that could enable the promotion of soy meat.
5.Promotion effect of TGF-β-Zfp423-ApoD pathway on lip sensory recovery after nerve sacrifice caused by nerve collateral compensation.
Pingchuan MA ; Gaowei ZHANG ; Su CHEN ; Cheng MIAO ; Yubin CAO ; Meng WANG ; Wenwen LIU ; Jiefei SHEN ; Patrick Ming-Kuen TANG ; Yi MEN ; Li YE ; Chunjie LI
International Journal of Oral Science 2023;15(1):23-23
Resection of oral and maxillofacial tumors is often accompanied by the inferior alveolar nerve neurectomy, resulting in abnormal sensation in lower lip. It is generally believed that spontaneous sensory recovery in this nerve injury is difficult. However, during our follow-up, patients with inferior alveolar nerve sacrifice showed different degrees of lower lip sensory recovery. In this study, a prospective cohort study was conducted to demonstrate this phenomenon and analyze the factors influencing sensory recovery. A mental nerve transection model of Thy1-YFP mice and tissue clearing technique were used to explore possible mechanisms in this process. Gene silencing and overexpression experiments were then conducted to detect the changes in cell morphology and molecular markers. In our follow-up, 75% of patients with unilateral inferior alveolar nerve neurectomy had complete sensory recovery of the lower lip 12 months postoperatively. Patients with younger age, malignant tumors, and preservation of ipsilateral buccal and lingual nerves had a shorter recovery time. The buccal nerve collateral sprouting compensation was observed in the lower lip tissue of Thy1-YFP mice. ApoD was demonstrated to be involved in axon growth and peripheral nerve sensory recovery in the animal model. TGF-β inhibited the expression of STAT3 and the transcription of ApoD in Schwann cells through Zfp423. Overall, after sacrificing the inferior alveolar nerve, the collateral compensation of the ipsilateral buccal nerve could innervate the sensation. And this process was regulated by TGF-β-Zfp423-ApoD pathway.
Mice
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Animals
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Lip/innervation*
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Prospective Studies
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Mandibular Nerve/pathology*
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Sensation/physiology*
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Trigeminal Nerve Injuries/pathology*