Objective To analyze the prognosis of elderly patients with community-acquired pneumonia (CAP) and its correlation with serum angiopoietin 2 (Ang-2), activated protein C (APC) and pentraxin 3 (PTX3) levels. Methods A total of 508 elderly patients with CAP in the hospital from March 2021 to March 2024 were divided into death group (n=104) and survival group (n=404) according to the survival status at 28 days after admission. Another 110 healthy subjects with physical examination were included in the control group. The levels of serum Ang-2, APC and PTX3 were compared, and their correlation with prognosis was explored by Pearson correlation analysis. Results In this study, 404 cases survived after 28 days and 104 cases died. The levels of C-reactive protein, procalcitonin and interleukin-8 and the proportion of severe condition in the survival group were lower than those in the death group (P<0.05). The level of serum APC in the case group and the death group was lower than that in the control group and the survival group (P<0.05), while the levels of Ang-2 and PTX3 were higher than those in the control group and the survival group (P<0.05), respectively. Serum APC level was negatively correlated with community-acquired pneumonia in the elderly CAP (r=-0.476, P<0.05), while Ang-2 and PTX3 were positively correlated with prognosis (r=0.489, 0.502, P<0.05). Conclusion Serum levels of Ang-2 and APC in elderly patients with CAP are decreased and the level of PTX3 is increased. Serum Ang-2 and APC levels are negatively correlated with elderly CAP, and PTX3 is positively correlated with prognosis.

Objective To discuss clinical efficacy of shuxuetong in treatment of pulmonary fibrosis. Methods Selected 60 cases with pulmonary fibrosis and they were divided into control group of 30 cases treated by prednisone and study group of 30 cases treated by shuxuetong based on treatment of prednisone. Lung function, arterial blood gas and lung CT were compared. Results The efficiency of study group was higher than control group (P<0.01). FEV1 of study group after treatment was higher than before treatment, and was higher than control group after treatment(P all<0.05). PaO2 of study group after treatment improved apparently, and was higher than control group (P<0.05). Conclusion Clinical effi-cacy and lung function of mild, moderate pulmonary fibrosis patients are improved with treatment of shuxuetong based on prednisone.

Objective To discuss serum IL-13, TGF-β1, IL-8 levels in idiopathic pulmonary fibrosis and correlation with lung function. Methods A total of 60 cases with idiopathic pulmonary fibrosis were selected as pulmonary fibrosis group, and 60 healthy volunteers were selected as control group. Serum IL-13, TGF-β1, IL-8, arterial blood gas analy-sis and related indicators of lung function were detected. Results Serum IL-13, TGF-β1, IL-8 levels of idiopathic pul-monary fibrosis group were higher than the control group(P<0.01). TGF-β1, IL-8 were significantly negative correlation with FVC predicted percentage (P<0.01); TGF-β1, IL-13 were significantly negative correlation with FEV1 predicted percentage (P<0.01); TGF-β1 and PaO2 was significantly negative correlation, and TGF-β1, IL-8 were significantly positive correlation with P(A-a)O2 (P<0.01);IL-8 was significantly negative correlation with PaO2 and SaO2 (P<0.01). Conclusion Serum IL-13, TGF-β1, IL-8 levels in idiopathic pulmonary fibrosis increase significantly, and are nega-tive correlation with lung function.