OBJECTIVE:To prepare levofloxacin hydrochloride ear drops METHODS:The content of levofloxacin hydrochloride was determined with UV-spectrophotometry RESULTS:The linearity range was 2～10?g/ml with a regression equation of A=1 83?10-3+0 07 415C and r=0 9 991(n=5) The average recovery was (98 74?0 51)% CONCLUSION:The UV-spectrophotometry method is simple,rapid and accurate and the preparation is powerful in antibacterial action and stable in quality