1.Clinical effect of transarterial chemoembolization combined with endovascular implantation of iodine-125 seeds in treatment of primary liver cancer complicated by portal vein tumor thrombus
Qiaoyu WANG ; Jie PAN ; Yuanmin ZHOU
Journal of Clinical Hepatology 2018;34(1):137-141
Objective To investigate the clinical effect of transarterial chemoembolization (TACE) combined with endovascular implantation of iodine-125 seeds in the treatment of primary liver cancer complicated by portal vein tumor thrombus (PVTT) and its influence on liver function. Methods A retrospective analysis was performed for the clinical data of 96 patients with primary liver cancer complicated by PVTT who were admitted to Guangzhou No. 12 People's Hospital from January 2013 to December 2016. Among these patients, 52 were treated with TACE combined with endovascular implantation of iodine-125 seeds in the portal vein (combination group) and 44 were treated with TACE alone (control group) . The two groups were compared in terms of the outcome of tumor lesions and PVTT and the changes in related laboratory markers after treatment. The t-test was used for comparison of continuous data between groups, and the chi-square test was used for comparison of categorical data between groups. Results Compared with the control group, the combination group had significantly higher remission rates of tumor lesions (59. 62% vs 38. 64%, χ2= 4. 196, P = 0. 041) and PVTT (80. 77% vs 59. 09%, χ2=5. 421, P = 0. 020) . At 8 weeks after surgery, the combination group had significantly lower serum alpha-fetoprotein (AFP), diameter of the main portal vein, and platelet count (PLT) and significantly higher serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin (TBil) than the control group (t = 3. 891, 3. 291, 2. 330, 3. 729, 3. 582, and 4. 126, all P <0. 05); both groups showed significant increases in serum levels of ALT, AST, and TBil (all P < 0. 05) and significant reductions in PLT, serum AFP and diameter of the main portal vein (all P < 0. 05) . Conclusion TACE combined with endovascular implantation of iodine-125 seeds in the portal vein has a better clinical effect than TACE alone in the treatment of primary liver cancer complicated by PVTT, but more attention should be paid to liver impairment during treatment.
2.Relationship between empathy ability and perceived social support in military college students
Mi SONG ; Jingcheng ZHOU ; Jiao MA ; Qi LI ; Jingpeng ZHOU ; Yuanmin JIA ; Chunping NI
Chinese Mental Health Journal 2019;33(2):149-152
objective: To investigate the status of empathy ability and perceived social support in military college students, and to explore the relationship between empathy ability and perceived social support. Methods: A total of 472 college students were selected from 5 military academies. The Interpersonal Reactivity Index-C (IRI-C) and Perceived Social Support Scale (PSSS) were used to evaluate the empathy ability and the perceived social support ability of military college students. Results: The total scores of IRI-C and PSSS were (51. 2 ± 10. 8) and (65. 8 ±11. 5), respectively. The total scores of PSSS and its three dimensions (family support, friend support and other support) were positively correlated with the total scores of IRI-C and its three dimensions (empathy concern, perspective taking and fantasy) (r = 0. 19-0. 35, Ps < 0. 01). The scores of empathy concern and perspective taking could positively predict the total scores of PSSS (β = 0. 29, P < 0. 001; β = 0. 15, P < 0. 001). Conclusion: It suggests that the empathy ability of military college students is at the middle level. Empathy ability could predict perceived social support in military college students.
3.Research progress of lncRNA regulating miRNA in osteoarthritis
Jichao BIAN ; Li WANG ; Xiaopeng ZHOU ; Bingliang LI ; Zhimeng WANG ; Long YUAN ; Sen LI ; Yuanmin ZHANG ; Guodong WANG
Clinical Medicine of China 2022;38(2):183-187
Non-coding RNAs (ncRNAs), which are thought to regulate articular cartilage through endochondral osteogenesis, consist of mRNA-interfering complementary RNA (miRNA) and long non-coding RNAs (lncRNA). More and more experimental evidence reveals the role of ncRNAs in chondrocyte differentiation and the pathogenesis of several skeletal diseases, including osteoarthritis. In the past few years, increasingly sophisticated DNA sequencing methods and a large number of sepigenetic modifications have greatly contributed to our understanding of the pathophysiological mechanisms of osteoarthritis. Recent studies have revealed that RNA interacts with RNA-binding proteins, regulates gene transcription and protein translation, and is involved in various pathological processes in OA, promising to be a therapeutic target for osteoarthritis.
4.Research progress on risk factors for acute aortic dissection complicated with acute lung injury
Wenjun ZHOU ; Wencui CHI ; Wanshun LI ; Bing SONG ; Yuanmin LI
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery 2021;28(12):1503-1507
Acute lung injury is one of the common and serious complications of acute aortic dissection, and it greatly affects the recovery of patients. Old age, overweight, hypoxemia, smoking history, hypotension, extensive involvement of dissection and pleural effusion are possible risk factors for the acute lung injury before operation. In addition, deep hypothermia circulatory arrest and blood product infusion can further aggravate the acute lung injury during operation. In this paper, researches on risk factors, prediction model, prevention and treatment of acute aortic dissection with acute lung injury were reviewed, in order to provide assistance for clinical diagnosis and treatment.