1.Application of dual-energy subtraction technique in diagnosis of occupational pneumoconiosis
xie yuanlin ; huang liming ; deng xuening
China Occupational Medicine 2022;49(2):206-210
Objective To explore the application value of chest dual-energy subtraction (DES) technology in the diagnosis of
occupational pneumoconiosis. Methods A total of 86 patients with suspected pneumoconiosis and 21 dust-exposure workers
were selected as the research subjects using random sampling method. The posterior and anterior chest radiographs were taken
by digital radiography (DR) and DES technology, and the difference of chest radiographs of DR, DES and combined groups were
compared. Results The positive rate of superior chest radiographs in DR group was higher than that in DES group (72.9% vs
56.1%, P<0.05). The determination of shadow shape and size, total density and stage of pneumoconiosis on chest radiographs in
DES group and combined group were consistent with those in DR group (all Kappa values >0.75, all P<0.01). However, the
judgment of small shadow intensity, small shadow aggregation and large shadow distribution in the two groups were not superior
to those in the DR group (Kappa value was 0.67, 0.74, both P<0.01). There was no significant difference between DES group and
DR group in the determination of small shadow intensity, small shadow aggregation and large shadow distribution (P>0.05).
However, there were statistically significant difference in this index between the combined group and DES group and DR group
(all P<0.01). There was no statistically significant difference in shadow shape and size, total density and stage of pneumoconiosis
in chest radiographs among these three groups (all P>0.05). Conclusion There was no difference between DES alone and DES
combined with DR for the diagnosis of pneumoconiosis in terms of shadow shape and size, total density and stage of
pneumoconiosis when compared with the gold standard DR. The value of DES in the diagnosis of pneumoconiosis needs further
study.
2.Non-target metabolomics pfofiling of neuromyelities optica spectrum disorder
Jun DENG ; Xiao JIAO ; Danqing SHANG ; Jie NI ; Yuanlin YING ; Bo XIAO ; Wenbin ZHOU ; Huan YANG ; Jing LI
Journal of Chinese Physician 2018;20(11):1617-1621,1626
Objective To investigate the metabolomics characteristic of neuromyelities optica spectrum disorder (NMOSD) in plasma and cerebrospinal fluid.Methods Ultra high performance liquid chromatography-mass spectrometry (UHPLC-MS) was used to identify plasma metabolites in 16 patients with NMOSD and 8 healthy controls.At the same time,the identification of metabolites in cerebrospinal fluid of 8 NMOSD patients and 5 healthy controls was completed.Differential metabolites screening and metabolomic pathway analysis were performed by diversified data analysis methods.Results Compared with healthy control group,the content of 8 substances such as Cis.8.11.14.Eicosatrienoic acid in the plasma of NMOSD patients was increased.The content of 8 substances such as L-glutamine acid were decreased.There was no significant difference in the metabolites between Aquaporin 4 (AQP-4) antibody positive and negative NMOSD plasma.The content of 6 substances such as 3-hydroxybutyric acid in cerebrospinal fluid of patients with NMOSD was reduced.Conclusions The distribution of metabolites in plasma between NMOSD patients and healthy controls was significantly different.There was no significant difference in metabolites between AQP-4 antibody positive and negative NMOSD plasma.There are some differences in metabolites between cerebrospinal fluid of NMOSD patients and healthy controls.A variety of amino acid abnormalities,sphingomyelin dysfunction,energy metabolism and mitochondrial dysfunction were involved in the pathogenesis of NMOSD.
3.Advances in blocking pulmonary circulation to identify intersegmental plane during pulmonary segmentectomy
Yuanlin DENG ; Hongtao TIE ; Mingjian GE
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery 2022;29(10):1390-1394
Accurate identification of intersegmental plane is one of the key steps of segmentectomy. Identification of intersegmental plane is usually based on differences in ventilation or circulation between the targeted segment and the reserved segment. In recent years, many methods of showing the intersegmental plane after blocking pulmonary circulation have emerged, and these methods have simplified segmentectomy and shortened the operation time. In this paper, we reviewed the related methods of blocking pulmonary circulation to identify the intersegmental plane.
4.Application of pulmonary circulation single-blocking method in intersegmental plane identification during segmentectomy
Weijie SUN ; Min ZHANG ; Xu CHEN ; Yuanlin DENG ; Mingjian GE
Chinese Journal of Clinical Thoracic and Cardiovascular Surgery 2023;30(01):52-57
Objective To introduce a new method for identifying intersegmental planes during thoracoscopic segmentectomy using pulmonary circulation single-blocking in the target segment. Methods To retrospectively analyze the clinical data of 83 patients who underwent thoracoscopic pulmonary segmentectomy from January 2019 to March 2020 using the pulmonary circulation single-blocking method. There were 33 males and 50 females, with a median age of 54 (46-65) years, and they were divided into a single vein group (SVG, n=31) and a single artery group (SAG, n=52), and the clinical data of two groups were compared. Results The intersegmental planes were identified successfully in both groups and there were no statistically significant differences between the two groups in terms of intersegmental plane management (P=0.823), operating time (P=0.786), intraoperative blood loss (P=0.775), chest drainage time (P=0.659), postoperative hospital stay (P=0.824) or the incidence of postoperative complications (P=1.000). Conclusion The use of pulmonary circulation single-blocking for intersegmental plane identification during thoracoscopic segmentectomy is safe and feasible, and the intersegmental plane can be satisfactorily identified by the single-blocking of arteries or veins.