Objective To investigate the serum copeptin level in patients with acute pancreatitis and explore its clinical significance. Methods Sixty-three patients with acute pancreatitis were enrolled , 35 of which were diagnosed as mild acute pancreatitis (MAP), and the other 28 patients were diagnosed as severe acute pancreatitis (SAP). Serum copeptin levels of all patients were determined on admission , on the second day and the third day after admission, respectively. Thirty healthy subjects were enrolled as the control group. Results Serum copeptin level was obviously higher in patients with SAP than the healthy individuals (P < 0.05), and was also significantly higher in the SAP patients than in the MAP patients (P < 0.05). Moreover, the serum copeptin level in SAP patients was highly associated with mortality and local complication (P < 0.01). Conclusion Serum copeptin level was increased at the early stage of acute pancreatitis and was associated with disease severity, which made it a potential diagnostic and prognostic marker for acute pancreatitis.

[Objective] Probing into the effect of Changyanning syrup about colonic electrophysiology and motility of visceral hypersensitivity rat.[Methods] The test consists of the model series and the control series and the Changyanning syrup series,and the two latter rats were sensitized by intraperitoneal injection of chicken egg albumen.After two weeks,the stomach is poured 0.7ml's normal saline by blank space series,0.7ml's normal saline by model series,0.7ml's Changyanning syrup by Changyanning series.Continue to pour stomach in a month,writing colon fast wave,slow wave and the colon contraction,the observation of interdigestive myoelectric complex IMC cycle,Ⅲ times duration,fast wave and slow wave propagation rate,the largesttest amplitude,the amount of the colon contraction,the index of the colon contraction.[Result] The model series' interdigestive myoelectric complex IMC cycle prolongs,Ⅲ times duration prolongs,fast wave and slow wave propagation rate speeds up,the largesttest amplitude broadens.The slow wave propagation rate speeds up.The amount of the colon contraction speeds up,the index of the colon contraction speeds up.After Changyanning series treated,interdigestive myoelectric complex IMC cycle cuts down,Ⅲ times the duration cuts down,the largesttest amplitude decreases.[Conclusion] There are quite differencs between model group and control group in electricity and motion of visceral hypersensitivity rat.Changyanning syrup treating visceral hypersensitivity is by means of partly recovering the colon fast and slow wave and contraction wave rhythm and amplitude.