Objective To evaluate the value of carcino embryonic antigen(CEA),carbohydrate antigen 19,cytokeratin(CYFRA21-1),squamous cell cancer antigen(SCC) and neuron specific enolase(NSE) for the evaluation of chemotherapy response in the patients with advanced lung cancer.Methods One hundred and thirty-six patients with advanced lung cancer(lung cancer group) and 40 patients with lung benign disease(control group) were collected.The lung cancer group was treated with at least two courses of chemotherapy.The CYFRA21-1,SCC,CEA and NSE levels before chemotherapy were compared among the lung cancer group,control group and the patients with different pathological types.The above mentioned tumor markers levels before and after chemotherapy were compared among the patients with different curative effects in the lung cancer group.Results The levels of serum NSE,CYFRA21-1,CEA and SCC before treatment in the lung cancer group were higher than those in the control group(P<0.01);the serum CEA level of the squamous carcinoma group was higher than that of the adenocarcinoma group and the small cell carcinoma group(P<0.01),and the serum NSE level of the small cell carcinoma group was higher than that of the adenocarcinoma and squamous cell carcinoma group(P<0.01),and the levels of CYFRA21-1 and SCC of the squamouscarcinoma group were higher than those of the adenocarcinoma and small cell groups(P<0.01).The serum CEA level of patial remission(PR) patients in adenocarcinoma group was significantly decreased(P<0.01),the serum SCC level of PR patients in the squamous cell carcinoma group was significantly decreased(P<0.05),and the serum NSE level of PR patients in small cell carcinoma group was significantly decreased after chemotherapy(P<0.01).The difference of serum NSE,CYFRA21-1 and SCC after chemotherapy in stnble and prosgoressive patients of various groups were not statistically significant(P>0.05).Conclusion CEA,CYFRA21-1,SCC and NSE can be used as the effective evaluation indexes of chemotherapy in lung adenocarcinoma,lung squamous cell carcinoma and small cell carcinoma,but which has little significance in the patients without effect of chemotherapy.

Objective To evaluate the accuracy of simple anthropometric parameters in diagnosing obesity in children in Guangzhou. Methods A cross-sectional study, including 465 children aged 6-9 years, was carried out in Guangzhou. Their body height and weight, waist circumference (WC) and hip circumference were measured according to standard procedure. Body mass index (BMI), waist to hip ratio (WHR) and waist-to-height ratio (WHtR) were calculated. Body fat percentage (BF%)was determined by dual-energy X-ray absorptiometry. Multiple regression analysis was applied to evaluate the correlations between age-adjusted physical indicators and BF%, after the adjustment for age. Obesity was defined by BF%. Receiver operating characteristic (ROC) curve analyses were performed to assess the diagnostic accuracy of the indicators for childhood obesity. Area under-ROC curves (AUCs) were calculated and the best cut-off point that maximizing'sensitivity+specificity-1'was determined. Results BMI showed the strongest association with BF% through multiple regression analysis. For'per-standard deviation increase' of BMI, BF%increased by 5.3%(t=23.1, P<0.01) in boys and 4.6%(t=17.5, P<0.01) in girls, respectively. The ROC curve analysis indicated that BMI exhibited the largest AUC in both boys (AUC=0.908) and girls (AUC=0.895). The sensitivity was 80.8% in boys and 81.8% in girls, and the specificity was 88.2%in boys and 87.1%in girls. Both the AUCs for WHtR and WC were less than 0.8 in boys and girls. WHR had the smallest AUCs (<0.8) in both boys and girls. Conclusion BMI appeared to be a good predicator for BF%in children aged 6-9 years in Guangzhou.