1.Layered dissolving microneedles as a need-based delivery system to simultaneously alleviate skin and joint lesions in psoriatic arthritis.
Kaiyue YU ; Xiuming YU ; Sisi CAO ; Yixuan WANG ; Yuanhao ZHAI ; Fengdie YANG ; Xiaoyuan YANG ; Yi LU ; Chuanbin WU ; Yuehong XU
Acta Pharmaceutica Sinica B 2021;11(2):505-519
Psoriatic arthritis (PsA) is a complicated psoriasis comorbidity with manifestations of psoriatic skin and arthritic joints, and tailoring specific treatment strategies for simultaneously delivering different drugs to different action sites in PsA remains challenging. We developed a need-based layered dissolving microneedle (MN) system loading immunosuppressant tacrolimus (TAC) and anti-inflammatory diclofenac (DIC) in different layers of MNs,
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