Objective:To explore the relevant factors associated with the progression of brain parenchyma hematoma following traumatic brain injury.Methods:The clinical data and CT findings of 114 patients with traumatic parenchyma hematoma in Jins-han Hospital,Fudan University from Mar 2000 to Mar 2014 were reviewed.The related factors for progression were analyzed by using Logistic regression analysis.Results:The main influence factors for the progression of traumatic parenchyma hematoma were primary hematoma quantity,subarachnoid hemorrhage,subdural hematoma.The pupil change,lower Glasgow coma scale (GCS)score,midline shift,effacement of basal cisterns were strongly associated with late surgical evacuation.Conclusions:Pa-tients with Traumatic parenchyma hematoma associated with subarachnoid hemorrhage,subdural hematoma,or large initial he-matoma quantity,should be monitored carefully with repeat head CT imaging.The pupil change,lower GCS score,midline shift,effacement of basal cisterns are strongly predictive of operative management.