0.05);the bacteriological effection rates were 62.50% vs. 40.43%(P

OBJECTIVE:To probe into the characteristics of adverse drug reactions (ADR) occurred in our hospital. METHODS: 340 ADR cases collected from Jan. 2004 to Dec. 2008 in our hospital were analyzed retrospectively. RESULTS: Of the total 340 ADR cases,80 (23.53%) were collected from pharmacy department;63.83% occurred in patients aged from 21 to 60 years,with females showing higher proportion than males;83.24% were induced intravenously,48.08% were induced by anti-infective drugs,of which,cephalosprins and quinolones took the lead. 38.05% of the ADR manifested as lesion of skin and its appendants. CONCLUSION: ADR monitoring should be strengthened in clinic;furthermore,the quality of ADR reporting should be improved and the use of drugs should be rationally in a standard way so as to lessen or avoid the occurrence of ADR.

OBJECTIVE:To optimize the decoction technology of Zhuanggufang decoction powder. METHODS:Central com-posite design with 2 factors and 5 levels was conducted to design the test,taking water (fold) and decoction time as independent variables,the extraction amount of icariin and extraction yield overall desirability value of as dependent variables,regression equa-tion were fitted;response surface method was used to optimize the decoction technology of Zhuanggufang decoction powder,and was verified. It was compared with the traditional decoction piece effect. RESULTS:The optimized technology was decocted twice with 16-fold water,20 min each time;relative error of predicted and theoretical value by overall desirability value was 2.97%;af-ter decoction powder and piece decocted in the same conditions,the extraction amounts of icariin were 1.2343 μg/g and 1.1324μg/g,extraction yields were 23.73% and 17.84%,respectively. CONCLUSIONS:Central composite design-response surface meth-od optimizing decoction technology is simple and reliable,the optimized decoction technology is stable and feasible,and the decoc-tion capability of Zhuanggufang decoction powder is better than the traditional pieces.

OBJECTIVE:To probe into the utilization of traditional Chinese medicine (TCM) injection in our hospital from 2005 to 2009.METHODS:The utilization of TCM injection used in our hospital from 2005 to 2009 was analyzed statistically in respects of consumption sum,DDDs and DDC.RESULTS:The mean annual incremental rate of the consumption sum of TCM injection in our hospital reached 24.89%.TCM injection for blood-activiating and stasis-dissolving dominated the first places in the lists of consumption sum and DDD for 5 years.TCM injection for anti-tumor took up the leading place in the list of DDC.More than 80% of TCM injection were medica1 insurance drug and new rural cooperative medicare drugs.CONCLUSION:The utilization of TCM injection in our hospital is reasonable and increase year by year.TCM injection with suitable price and extract efficacy take up a big proportion in the clinical application.It should be strengthened to adopt TCM injection reasonably.

Objective:To investigate the association between levator hiatus area, pelvic organ prolapse quantification (POP-Q) examination and prolapse symptoms.Methods:The prospective multicenter study enrolled 996 female patients between January 2017 and January 2019. All enrolled patients underwent a standard clinical interview, POP-Q examination and transperineal ultrasound examination. Volume data of pelvic floor ultrasound examinations were obtained at rest, during contraction and during maximal Valsalva maneuver. The association between levator hiatus area, POP-Q examination and prolapse symptoms was analyzed. The performance of levator hiatus area on maximal Valsalva for assessing significant POP(POP-Q stage≥2) and prolapse symptoms were also evaluated.Results:There were significant differences of levator hiatus area at rest, during contraction and during maximal Valsalva among patients with different POP-Q stages (all P<0.001). Levator hiatus area during maximal Valsalva showed the highest correlation with abdominal dragging sensation ( r=0.277, P<0.001). The area under the ROC curve (AUC) of levator hiatus area during maximal Valsalva for significant POP (POP-Q stage≥2) was significantly higher than that for prolapse symptoms (AUC: 0.77 vs 0.69, P<0.001). Conclusions:Levator hiatus area on transperineal has moderate correlation with POP-Q examination and their association is stronger than the correlation between ultrasound findings and prolapse symptoms.

Objective:To investigate the feasibility of transperineal ultrasound in quantitative assessment of posterior compartment prolapse among Chinese women.Methods:The prospective multicenter study enrolled 485 women between January 2017 and January 2019. All patients underwent a standard clinical interview, pelvic organ prolapse quantification (POP-Q) examination and transperineal ultrasound examination. Volume data of transperineal ultrasound examinations were obtained at rest and in maximal Valsalva maneuver.Results:The higher POP-Q stage of posterior compartment, the lower rectal ampulla position in maximal Valsalva maneuver (POP-Q stage=0 vs POP-Q stage=1, P<0.001; POP-Q stage=1 vs POP-Q stage≥2, P<0.001), and the greater rectal ampulla hypermobility (POP-Q stage=0 vs POP-Q stage=1, P<0.001; POP-Q stage=1 vs POP-Q stage≥ 2, P=0.007). The rectal ampulla position at rest and in maximal Valsalva maneuver and rectocele depth were correlated with prolapse symptoms ( r=-0.200, P<0.001; r=-0.252, P<0.001; r=0.086, P=0.045). The corresponding cut-off values of rectal ampulla position in maximal Valsalva in diagnosing posterior compartment prolapse (POP-Q stage ≥1) and clinical significant posterior compartment prolapse (POP-Q stage ≥2) were 7.32 mm below the symphysis pubis and 12 mm below the symphysis pubis, respectively, with the area under the ROC curve as 0.75 and 0.85, respectively. Conclusions:The ultrasonic measurements by transperineal ultrasound is significantly associated with POP-Q examination in posterior compartment, and it is demonstrated as a useful tool in quantitative assessment of the severity of posterior compartment prolapse.