Objective To examine how early life exposure to famine would impact on liver and kidney functions and related chronic metabolic diseases during adulthood.Methods A random cluster sampling method was adopted in Anhui province,2011 from a physical examination center,in a first-class hospital.4 252 study subjects were born between 1957 and 1963.According to the time of birth:the study subjects were divided into three groups,respectively:1957-1958 (983 persons as pre-famine),1959-1961 (1 247 persons as exposed to famine) or 1962-1963 (2 022 persons as controls,also the post-famine).Variances between groups AST,ALT,r-GGT,differences in the levels of SCr,UA,UREA and the change trend were compared.Results ALT,IBIL,TBIL,SCr,UREA were statistically different (P＜0.05) among subjects born in the different years.r-GGT,ALT,AST,ALB,SCr were statistically different (P＜0.05) among males bornin different years so as the r-GGT,AST,ALB,GLB,TP,SCr,UA,UREA in females (P＜0.05).r-GGT,ALT,ALB,SCr differences statistically significant (P＜0.05) and r-GGT,AST,ALB,GLB,TP,SCr,UA,UREA in females were statistically significantly different (P＜0.05).Conclusion Early life poor nutrition could lead to developmental disorders,organ function damage in liver and kidney function during adulthood.Women appeared to have balanced diet nutrition during pregnancy which was far important in the prevention on adulthood chronic metabolic diseases.