Objective: Thyroid nodules are common clinical thyroid disorders.The purpose of this study was to investigate the diagnostic value of the clinical characteristics and various parameters of malignant thyroid nodules and the sensitive indexes for their differentiation so as to improve the diagnosis of malignant thyroid nodules and avoid unnecessary procedures or operations.Methods: We retrospectively studied 600 cases of thyroid nodules treated by surgery from 2001 to 2008,divided them into a benign and a malignant group according to the pathological results,and analyzed by multivariate logistic regression the correlation between the nature of thyroid nodules and various factors.Results: Of the 600 cases of thyroid nodules,519(83.47%) were benign and 81(16.53%) were malignant.Clinical symptoms and signs,ultrasonography and CT were all useful in indicating malignancy,especially ultrasonography,whose specificity and diagnostic accuracy were 93.3% and 84.2%,respectively.Multivariate logistic regression analysis revealed a higher rate of malignancy in younger patients with solid or hard nodules,or accompanied with calcification or painless adenophyma in the neck.Conclusion: Clinical symptoms and signs,ultrosonography and CT are of significant value in the diagnosis of malignant thyroid nodules.

Animals ; Humans ; Rats ; Respiratory Distress Syndrome, Adult ; etiology ; therapy

Objective:To analyze and discuss the factors of seizure induced by imipenem/cilastatin.Method: The reports of seizure induced by imipenem/cilastatin from CBMDisc(1971-2006)and CHKD(1994-2006)were re- viewed and analyzed with Excel.Result:28 cases of seizure induced by imipenem/cilastatin were collected,including 20 men and 8 women with the principal primary respiratory infection with an average age of 66.5.Seizure occurred as early as 10 min.after the medication,and occurred latest in the fourth day of the medication.22 cases showed grand mal seizure and 6,partial seizure with a duration ranging from 20s to 30min and with a frequency of eight seizures.18 cases discontin- ued the administration,and 8 cases took lower daily dosage,in which some were given antiepileptic drugs or other adjunc- tive therapy,and 2 cases were not treated at all.All the cases recovered and were discharged from hospital except one who died from his circulation failure and respiration failure.The cause-effect relations of the relevance evaluation of seizures e- yoked by imipenem/cilastatin were as follows:1 sure case,26 probable cases,and 1 possible case.Conclusion:Seizure can be induced by imipenem/cilastatin,Owhich should be rationally used.More attention should be paid in clinic so as to ensure a safe medication.

Reactive oxygen species (ROS) caused oxidative stress plays an important role in the occurrence and development of atherosclerosis,and it is associated with the occurrence of ischemic cerebrovaseular diseases.This article reviews the mechanism of action of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in atherosclerosis and ischemic cerebrovascular disease,and the neuroprotective effects of NADPH oxidase inhibitors.

Objective To investigate clinical value of serum procalcition(PCT) in early diagnosis of nosocomial infection in severe cerebral injury.Methods 58 patients with severe cerebral injury needing ICU monitoring were enrolled.Levels of serum PCT and C-reactive protein(CRP) and white blood cell(WBC) and nosocomial infection when entering ICU or on days 3 were observed.Results There were not difference in level Serum PCT when entering ICU in infection group compared with non-infection group(P ＞ 0.05).Serum PCT increeassd remarkably when entering ICU on days 3 in infection group as compared with non-infection group,the difference was significant (t =5.44,P ＜ 0.01).There were not difference in CRP and WBC level when entering ICU or on days 3 (all P ＞ 0.05).Conclusion Detection of serum PCT helps diagnosis early nosocomial infection in patients with severe cerebral injury.It is suggested that antibiotics should be chosen early in patients with obviously increased PCT,control abuse of antibiotics contributes to reduce incidence of drug resistance and mortality.

A case of mandible plasma cell myeloma is reported.Plasma cell myeloma is a monoclonal neoplastic proliferation of plasma cells of bone-marrow derivation,usually multi-centric but jaw bones are rarely involved.The treatment requires precise pathological diagno-sis.The prognosis of solitary jaw bone lesions can be good after treatment.

Objective To investigate the clinical characteristics of imflamatroy bowel disease (IBD) and the risk factors in developing eoloreetal cancers. Methods Five hundred and thirteen patients with IBD were consecutive collected from Jan. 1996 to Oct. 2007. The history database of these patients was established. The items including demography features, morbidity, diagnosis, the related risk factors, the treatment and outcomes were analyzed. Results Two hundred and forty two out of 513 patients were ulcerative colitis (UC). Of which 4 patients (1.65%) developed cancer and 4 (1.650%) were confirmed with precancer. But none of the 271 patients with Crohn's disease (CD) de-veloped cancer. The Logistic regression analysis showed that weight loss, complications and relapse might be the potential risk factors of the cancer. Conclusions In clinical, the probability that develope to cancer in patients with UC is higher than that in patients with CD. The main risk factors are frequent relapse, weight lost and complications.

The lipoprotein-associated phospholipase A2 (Lp-PLA2), a subtype of the phospholipase A2 superfamily, is produced primarily by macrophages and lymphocytes. Lp-PLA2specifically hydrolyzes oxidized phospholipids on oxidized low-density lipoprotein particles,resulting in production of lysophosphatidylcholine and oxidized fatty acids. Lp-PLA2 is expressed in atherosclerotic plaques and in macrophages within a fibrous cap of unstable plaque.Studies haw shown that the plasma Lp-PLA2 activity increases significantly in patients with ischemic stroke, and Lp-PLA2 may become an independent risk factor for predicting ischemic cerebrovascular events. The selective Lp-PLA2 inhibitor can reduce the inflammatory response,enhance the stability of plaques, and inhibit the formation of atherosclerotic plaques, and may become a new class of drugs for preventing the formation of atherosclerotic plaques.

Mechanical ventilation plays an important role in the treatment of preterm infants,especially respiratory problems.With improvement in both antenatal and neonatal care and therapeutic strategies,premature babies are surviving more than ever.However,the incidence of bronchpulmonary dysplasia remains high which affects the clihical outcomes of premature infants.Non-invasive respiratory support techniques have been used in attempts to decrease lung injury and the complications of preterm infants.This review will focus on various ventilation modalities for managing preterm infants with respiratory failure and lung protective ventilation strategies to minimize lung injury in preterm infants.

AIM: To recognize the importance of ADR monitoring of drugs available on the market from PPA Event. MET- HODS: With reviewing relevant literatures and scanning relevant network stations. we summarlzed the importance of moni- toring ADR of drugs available on the market and signiticance of creating a perfect evaluation mechanisms and systems of ADR monitoring for those drugs. and analysed several method of ADR monitoring and points for attention Finally. we gave several suggestions about enhancing ADR monitoring .RESULTS& CONCLUSION:ADR events can be effectively pre- vented by perfect evaluation mechanisms and ADR monitoring systems of drugs available on the market.