Objective To study the expression and significance of P57KIP2 in complete mole(CM ) and partial mole(PM).Methods The expression of P57KIP2 in histology unequivocal 45 cases of CM and 30 cases of PM was detected by immunohistochemistry method.Results In the PMs,expression of P57kip2 was strongly and continuously(30/34),in the CMs,it was absent or weak expressed (5/45).The difference of P57K1P2 expression between PMs and CMs was statistically significant( P ＜ 0.05 ).Conclusion P57KIP2 immunostaining is a sensitive sign of partial moleand in differential diagnosis of PM from CM and it is deserving of clinical application.

Diabetes Mellitus, Type 2 ; drug therapy ; Humans ; Hypoglycemic Agents ; therapeutic use ; Non-alcoholic Fatty Liver Disease ; drug therapy

Anaphylaxis ; chemically induced ; Anti-Bacterial Agents ; adverse effects ; Azithromycin ; adverse effects ; Fatal Outcome ; Humans

Quantum dots (QD),a kind of nanocrystal,are made from Ⅱ-Ⅵ or Ⅲ-Ⅴ group elements.It has been reported that compared with current conventional fluorescent markers,QD have excellent optical properties such as strong fluorescence,photochemical stability and can be used for simultaneous multi-channel imaging.Meanwhile,as nanoparticle,QD can be easily surface modified with a variety of biological molecular and can reach cancer cells easily by penetrating the tumor angiogenesis.Therefore,QD have unique advantages in targeted real-time visual imaging of in vivo tumor and have great prospects in the individual diagnosis and treatment of tumor.However,the long-term biosafety after QD into the body still needs further study.

Objective To investigate the significance of clinical nursing pathway in perioperative period of children with hypospadia.Methods 63 cases of hypospadia children patients were randomly divided into the control group (30 cases)and the experimental group (33 cases).The traditional nursing method was used in the control group,while the clinical nursing pathway was used in the experimental group.Results The hospital stay,hospital charges and complications of the experimental group were less than the control group.The satisfaction degree of the experimental group was higher than the control group.There was significant difference.Conclusions Clinical nursing pathway is a safe and effective nursing model.It can shorten hospital stay,reduce hospital charges,decrease complications,and improve patients' satisfaction degree.

Objective:To establish a method for the determination of residual 5 heavy metal elements in single use and gravity feed infusion sets and intravenous infusion needles, including Cd, Cr, Cu, Sn and Pb. Methods:After the pre-preparation,the sample was dissolved in 1% nitrate. The 5 heavy metal elements in the sample solution were determined by inductively coupled plasma mass spec-trometry (ICP-MS). Results:Under the ICP-MS assay conditions, each element showed good linearity within the range of 0-50 ng· ml-1(r>0. 999 0). The average recoveries were within the range of 92%-116% and 1. 6%-2. 9%, respectively (RSD<3,n=9). Conclusion:The operation is simple and can meet the demand for the analysis of heavy metal elements in single use and gravity feed infusion sets and intravenous infusion needles.

Education of medical morality is an important part of medical education and must be through the whole career life of medical workers.Now our society is in the period of transition,but education of medial morality fails to get enough attention.Based on the present situation,the paper first makes a systematic exposition of the importance,intension,element and process of the reception of medical morality education of medical workers,then points out the rule of this reception and the approach to realize the validity of medical morality education.

Circulating tumor cells (CTCs) play pivotal roles for monitoring the tumor metastasis and prognosis.The nanotechnology provides a favourable platform for CTCs detection,and enables CTCs to be more promising for practical application.Meanwhile,the nanoscale device by virtue of nanotechnology has broad application prospects in eliminating CTCs and offers a new direction in the field of anti-cancer.

The application of the multimedia combined with the PBL teaching model to the teaching of Gynaecology and Obstetrics is an open teaching model.It emphasizes that the class-teaching will be problem-based,and it can improve the students' initiative greatly and their enthusiasm as well.In this way,it can urge their desire to participate in the class-room activities and acquire knowledge.The method combined multimedia with PBL can also improve the teachers' teaching skills and their over-all clinical working abilities.

The application of standardized patient SP is the tendency of clinical medical education in China.Normative and effective SP training is the basis of good teaching quality of medical education.By introducing the experience about how to choose and train tandardized Pa-tients in medical teaching the author discusses its significances for the clinical education,with a view to further deepening SP follow—up to the teaching of medical and other clinical disciplines as well as providing a reference.