OBJECTIVE:To explore the pharmacoeconomic effect of Ginkgo dipyidamolum,argatroban or sodium ozagerl combined with edaravone in the treatment of acute cerebral infarction(ACI). METHODS:In retrospective study,64 ACI patients were divided into group A(Ginkgo dipyidamolum+edaravone,22 cases),group B(argatroban+edaravone,19 cases)and group C (sodium ozagerl+edaravone,23 cases). Therapeutic efficacies were observed after 7-14 days of treatment;therapy cost was calculat-ed,and cost-minimization analysis was used to evaluate pharmacoeconomics. RESULTS:There was no statistical significance in to-tal effective rate among 3 groups(P>0.05);the costs of group A,group B and group C were 8 746.36 yuan,10 770.64 yuan and 8 264.67 yuan. Results of sensitivity analysis were in line with those of cost-minimization analysis. CONCLUSIONS:Therapy plan of sodium ozagerl+edaravone is the economical regime in the treatment of ACI .

Hypopharyngeal cancer is not common and its prognosis is among the worst in head and neck cancer.Radiation therapy is an important choice of treatment,including radiotherapy alone,radiotherapy combined with surgery and radiotherapy combined with chemotherapy.The improvement of radiation therapy improves the prognosis of hypopharyngeal cancer patients,and radiotherapy combined with surgery is the standard treatment for hypopharyngeal cancer.Nowadays,in order to enhance the preserving rates of the organ and faction,radiotherapy combined with chemotherapy is becoming a research hotspot.

To summarize the application of proteomics to modernization research of Chinese materia medica (CMM) and offer the reference for modernization of CMM and new medicine preparation exploitation. Based on the references and our project group studies in proteomic of drug biosynthesis pathway and metabolization;the main content,technology strategies and important application of the proteomics were introduced significantly;and the further development of protemics was analyzed. The proteomics will become one of absolutely necessary tackles in the modernization research of CMM.

Catheter Ablation ; adverse effects ; Heart Septum ; surgery ; Humans

Objective To compare the advantages and disadvantages of the two methods.Methods Thirty BALB/c mice were randomly divided into 3 groups:normal control group,OVA group and OVA/RSV group.With ovalbumin and hydroxide suspension sensitized,OVA nouse asthma model group and OVA/RSV group were established respectively by continuous atomization of ovalbumin and repeated nasal drops of RSV.The control group was established by sensitization and atomization excitation of sterile injection water.24 hours after the last stimulation,the lung function was measured.The cell sorting and counting in bronchoalveolar lavage fluid were performed.The pathological changes of lung tissue were observed by HE staining.Results Compared with the control group,the model groups have obvious symptoms of asthma,airway wall thickening,lumen stenosis and a large number of inflammatory cell infiltration.And pathological damage of lung tissue in OVA/RSV group was significantly increased,compared with OVA group.The enhanced expiratory pause (Penh)values of OVA/RSV group were significantly higher than those in group OVA (P ＜ 0.05),and the number of neutrophils,monocytes,lymphocytes and eosinophils in BALF were significantly higher than those in OVA group (P ＜ 0.05).Conclusion The establishment of asthma mouse model by OVA sensitization and RSV induction is a better way to simulate the human asthma pathogenesis.

Objective To investigate the expression of Apelin in placenta tissue from women with hypertensive disorders complicating pregnancy.Methods Thirty six women with hypertensive disorders complicating pregnancy(HDCP)and 15 normal pregnant women were studied.The expression of Apelin-36 was analyzed semi-quantitatively using immunohisto-chemistry and image analysis in placenta tissue and the levels of Apelin mRNA expression were determined by real-time quantitative RT-PCR method.Results The levels of Apelin-36 and Apelin mRNA in placenta from normal pregnant women were 0.27?0.04 and 0.82 ?0.25,respectively.The levels of Apelin-36 and Apelin mRNA in placenta from HDCP women were 0.18 ?0.05 and 0.31?0.21;in gestational hypertensive women,the values were 0.24?0.02 and 0.59?0.16; in mild preeclampsia were 0.16?0.03 and 0.25?0.07,and in severe preeclampsia they were 0.14?0.02 and 0.17?0.09,respectively.The levels of Apelin-36 and Apelin mRNA in HDCP were lower than those in normal pregnant women(P

Objective An analytical approach has been developed for determination of sildenafil blood with high performance liquid chromatography.Methods Sildenafil was extracted by solid phase extraction cartridges from blood and was separated by resered-phase gradient chromatography with DAD detection at 230nm.The analytical column was Nova-pak C18(150×3.9mm),5.0μm and the guard column was Phenomenex C18(ODS,4.0×3.0mm,Octadecyl).The mobile phase Was gradient mixture of acetonitrile(A) and 0.25% acetonitrile aqueous solution including 0.06% trifluoroacetic acid and 0.06% triethylamine (B).Results Linearity Was checked over the concentration range 1.5～80.0μg/mL.Limits of detection was 5.0ng.Average recovery was 82.45%.Conclusion This method issimple.exact and rapid.

Objective: To study the preventive effect of microecological preparations on enteral nutrition related diarrhea in elderly patients.Methods:Sixty-two eldealy patients with enteral nutrition were divided into treatment group(n=30) and control group(n=32) at random.All patients were fed with Nutrtion Fibre.Treatment group was given with microecological preparations.The incidence rate of diarrhea,and the time to reach standard amount were recorded.Results: The incidence rate of diarrhea in the treatment group was 13.33%,and the incidence rate of diarrhea in the control group was 37.50%(P

Objective To analyze the changes of distribution and drug resistance of isolated pathogens for ventilator-associated-pneumonia (VAP) in seven intensive care units from January 2013 to December 2015,so that provides information for clinical antibiotic treatment.Methods Collected the patient records diagnosed with VAP to get the distribution and drug resistance of isolated pathogens for VAP in ICU from January 2013 to December 2015.Compared the distribution of isolated pathogens for VAP among three year with Chi-square tests,and compared the drug resistance of main isolated pathogens with Nonparametric tests.Results 177 patients were diagnosed with VAP from January 2013 to December 2015.A total of 192 strains of pathogens were isolated from the VAP patients in ICU.Among which the gram-negative bacteria were dominant.It took up 90.6％.There was no significant statistical difference for the distribution of pathogens (x2 =2.372,P=0.668＞0.05).Analyzed the drug resistance rate and trends for the primary pathogens like Acinetobacter Bauman,Pseudomonas aeruginosa and Staphylococcus aureus,among which,the drug resistance of Acinetobacter Bauman from 2013 to 2015 made statistical difference.Conclusion The major pathogen isolated from VAP patients was gram-negative bacteria from January 2013 to December 2015,especially for Acinetobacter Bauman.Drug resistance of Acinetobacter Bauman was serious.Should administrated appropriate to treat the VAP infection resulted from Acinetobacter Bauman.

A strain of resistance to copper and cadmium with high concentration, named NTG-01, was isolated from soils of DaYe county mineral area in HuBei province. It can resist copper of 4.5mmol/L and cadmium of 2mmol/L , so we can say that it is a important strain used to study the resistance mechanism of copper and cadmium. A series of morphological and biochemical characteristics and sequences analysis of 16S rDNA reveal that it belongs to the bacteria and is gram negative, short rod, flagella around, the size of bacteria is about 0.8?m?2.0?m , V-P result shows positive, methyl-red result displays negative, and glucose can be utilized to produce acid and gas; In addition to, we find that it has the percent 99 homologous to Enterobacteraerogenes by 16S rDNA sequences BLAST analysis, plus the results of morphological and biochemical parameters, it belongs to Enterobacteraerogenes. We can conclude that NTG-01 has higher resistance to many different heavy metals by measuring MICs values of nine heavy metals at last.