The incidence of venous thromboembolism (VTE) in multiple myeloma patients is higher than that of normal population. In this review, recent advances about thrombosis in multiple myeloma are studied,including the mechanism,risk factors,therapy and prevention of thrombosis.

The treatment of relapsed and refractory multiple myeloma has always been a problem among hematologic malignant tumor treatment.Compared with the initial therapy,there are worse therapeutic effects and more affecting factors of selecting treatment since the existence of drug resistance in relapsed myeloma.In this review,the therapeutic effects of single and combinational use of several novel agents such as thalidomide,lenalidomide and bortezomib were evaluated in treating relapsed and refractory multiple myeloma.The clinical results of some new anti-myeloma agents were also reported.

BACKGROUND:Platelet-rich plasma gel contains some kinds of growth factors, which play important roles in repair of local trauma and bone defects. Platelet-rich plasma gel is now more and more studied as tissue engineering scaffolds, but there are no unified preparation methods.
OBJECTIVE:To summarize the studies about the preparation methods of platelet-rich plasma gel and the growth factors in platelet-rich plasma gel in recent years, and to compare different methods in order to find which one is better.
METHODS:A online search of PubMed database from January 1980 to January 2013 and China National Knowledge Infrastructure from January 1980 to January 2013 was performed with the key words of“platelet-rich plasma, platelet-rich plasma gel, tissue engineering”in English and Chinese, respectively. The studies about detection and preparation methods of platelet-rich plasma were included and those unrelated to platelet-rich plasma were excluded. Final y, 322 articles were gained and 67 articles were included in result analysis.
RESULTS AND CONCLUSION:Al preparation methods have their advantages. We should select the suitable method according to the goal of study. With the further study of platelet-rich plasma, it wil become more and more important for bone defect repair and tissue engineering research.

Applying H-index combined with other evaluation index of qualitative and quantitative evaluation for seientifie research ability, levels of researchers as well as academie journals, is becoming inereasingly concerned and will gradually be applied. The paper discusses the connotation, extension, feasibility, limitations on H-index and further analyzes the applicability of using H-index to evaluate the quality of academic journals.

Objective To evaluate the clinical efficacy of Memotherm TM stent,a type of metallic stent in the management of secondary ureteropelvic junction obstruction. Methods From October 1995 to June 2001,13 cases (10 males and 3 females,mean age of 41 years) of secondary ureteropelvic junction obstruction underwent the Memotherm TM stenting.They were all followed up for an average of 26 months by B ultrasound,IVU,radionuclide renography and ureteroscopy. Results Of the 13 case,8 were cured,and 3 achieved improvement,while 2 cases failed.The main complications of endoprosthetic fibrotic stricture occurred in 5 cases.The forceps or YAG laser through ureteroscopy was used to remove the endoprosthetic fibrotic tissues. Conclusions Memotherm TM stent is mostly effective in the treatment of patients with secondary ureteropelvic junction obstruction,especially for patients who has undergone multiple operations or those are ineligible for open surgery.This procedure can significantly reduce the recurrence of ureterostenosis.

Objective To summarize the causes of failed drainage of double J ureteral stents following ureteroscopy. Methods From June 2000 to March 2003,the double J ureteral stents were placed for 3972 patients (2184 males and 1788 females)following ureteroscopy.The stents were placed through retrograde approach in 3138 cases,through antegrade approach in 1497 cases.The patients were followed up until the ureteral stents were retrieved. Results Of the 4635 cases,failed drainage of double J ureteral stent was found in 115 cases (2.48%).The main causes were severe extra luminal obstruction,serious steinstrasse,severe ureteral stricture and overperiod placement of ureteral stents. Conclusions Correctly identifying the indications for ureteroscopy and the placement of double J ureteral stents as well as close follow up are the keys to reduce the failure rate of drainage of double J ureteral stents following ureteroscopy.

Objective To describe the preoperative factors of prolonged intensive care unit length of stay after coronary artery bypass grafting. Methods From 1997 to 2009, 1318 patients underwent isolated CABG in our hospital. Retrospective analysis was performed on these cases. Univariate and multivariate analyses for preoperative risk factors were performed. Prolonged length of ICU stay was defined as initial admission to ICU exceeding 72 h. Results The mean age of patients ( 322women and 996 men) was (67.4±9.4) years. Of 1318 patients undergoing isolated CABG from 1997 to 2009, 205 experienced prolonged length of ICU stay. The length of ICU stay was (40.1 ± 22.5 ) hours and ( 122.6 ± 48.7 ) hours separately.Overall in-hospital mortality was higher among these 205 patients ( 13.7% vs. 1.2%, P ＜0.05 ). The overall mortality was 3.1%. In univariate analyses, there were statistically significant differences with respect to the percentage of CPB, total bypass time, cross-clamp time, number of distal anastomoses, use of pressor agent, use of intro-aortic balloon pump,time of ventilation and hospital mortality. The significant risk factors were age, NYHA class Ⅲ/Ⅳ, left ventricular ejection fraction(LVEF) ＜0.40, renal failure, cerebrovascular and/or peripheral vascular disease, chronic obstructive pulmonary disease, recent acute myocardial infarction, prior percutaneous coronary intervention, left main stenosi, three-vessels disease. The variables entered into the multivariate logistic regression were age, NYHA class Ⅲ/Ⅳ, LVEF ＜0.40, renal failure, chronic obstructive pulmonary disease, recent acute myocardial infarction, prior percutaneous coronary intervention, three-vessels disease. According to the outcome of multivariate logistic regression, we can conclude the model of probability forecast and create a new variable named Pre. The area under ROC curve of the new variable Pre was larger than other variables. Conclusion The main risk factors of prolonged ICU length of stay were LVEF ＜ 0.40, recent acute myocardial infarction, renal failure and chronic obstructive pulmorary disease. The AUC of variable Pre was higher than other' s , which indicated that new variable Pre combining each variable was more valuable than single variable with respect to prediction. A predicted probability of 0. 754 was used as cut-off point for the prognostic test.

The protein,the fats,the carbohydrate and the nucleic acid are the main constituent material of normal cell and organizations. In the early process of becoming malignant,these chemical substance's structure,the conformation and quantity has had the obvious change,but this time clinical symptoms and medicine phantom study still has not obvious change.But the Raman spectrum can actually reflect these changes.Therefore the Raman spectrum technology becomes important means of the malignant tumor early diagnosis and the cancer mechanism research hopefully.This article makes a summary on the present as well as the progress reviewed of Raman spectrum technology in the tumor research application.

OBJECTIVE: To elucidate the important role of calcium and calreticulin in cardiomyocyte.DATA SOURCES: We searched PubMed database for articles about the role of calcium and calreticulin in the cardiomyocyte published in English from January 1994 to December 2005 with the key words of "Ca2+, calreticulin, cardiomyocytes/ cardiac myocyte, differentiation".STUDY SELECTION: The retrieved data were selected primarily and articles about the important role of calcium and calreticulin in the cardiomyocyte were selected. Meanwhile, articles of repetitive research were excluded.DATA EXTRACTION: Totally 200 articles were researched, 42 were included, and 158 were excluded.DATA SYNTHESIS: Investigation on the molecular structure of the intracellular Ce2+ release channels (RyR and IP3R) on the endoplasmic reticulum and sarcoplasmic reticulum and structure of crt gene manifests that these channels co-participate in the regulation of calcium homeostasis with calreticulin, which plays a key role in cardiac development and differentiation.CONCLUSION: Intracellular free Ca2+ is a critical second messenger in heart. Alterations in intracellular Ca2+ homeostasis have profound effects on cardiac functions such as contraction-relaxation and cardiac development. Intracellular Ca2+ homeostasis is maintained primarily via the endoplasmic reticulum, within which, Ca2+ is mainly bound to calreticulin.Knockout of crt gene is embryonically lethal due to impaired cardiac development.

Tissue factor (TF), a transmembrane glycoprotein with a molecular mass of 47000, plays an important role of coagulation within vessel wall. Recently, people also present that TF have identifying and regulating function in cells signaling. And it contributes in the pathogenesis of atherosclerosis, angiogenesis and restenosis. This review presents the development of TF in above mentioned .