Adenoviridae ; genetics ; Genes, p53 ; Genetic Therapy ; methods ; Genetic Vectors ; Humans ; Neoplasms ; therapy ; RNA Interference ; Tumor Suppressor Protein p53 ; genetics

OBJECTIVE:To evaluate the effects of compound amino acids capsul es on hypoalbuminemia in patients with chronic renal failure undergoing hemodialysis.METHODS:30hemodialysis patients were selected to orally take2compound amino acids capsules(0.35g per capsule)twice daily for12weeks,renal and liver function and levels of serum albumin and pre-albumin were measured before and after the experiment.RESULTS:The levels of serum albumin and pre-albumin were increased significantly after the treatment,it were(30.5?4.6)g/L vs(35.9?7.1)g/L,and(213.0?46.9)mg/L vs(275.8?52.3)mg/L respectively(P

Psoriasis is a recrudescent chronic inflammatory dermatosis which is called“tinea”in ancient times. Its pathogenesis is not only associated with changes in the blood and body fluids, but also has close connection with external infection of six evil factors. This article sorted data of pathogenesis and treatment from the perspective of external infection of six evil factors, and discovered that pathogenesis of psoriasis includes external factors of four evils of wind, cold, damp and heat and internal factors of blood deficiency and blood dryness. Ancient treatment was based on dispelling wind, clearing away heat and moistening dryness. The pathogenesis can be summarized as follows:wind and poison attack skin and hinder blood production. The treatment can be “let in air for detoxification, enrich blood and moister dryness, cooling and activating blood”, blood and functional status of organs of patients should be observed, with a purpose to provide references and basis for modern clinical prevention and treatment of psoriasis.

Objective To investigate the effect of interferon alfα-2b on the ultrastructure and Caspase-3 levels in villus in early pregnancy with bacterial vaginal disease (BV). Method Early pregnant women were divided into two groups. The treated group included 25 early pregnant women with BV who chose to have an early termination and were treated with rhINFα-2b. The controling group included 30 early pregnant women without any genital tract infectious diseases. The caspase-3 levels in trophocytes were detected by immunochemistry and the ultrastructural changes were observed in villus by transmission electron microscopy. Result (1)There was no apparent difference of ultrastructural changes between the two groups. (2)There was no statistical significance of the levels of caspase-3 between the two groups (P>0.05). Conclusion The excessive apoptosis do not occur in the trophocytes when treated with INFα-2b.

Animals ; Botulinum Toxins ; adverse effects ; therapeutic use ; Bruxism ; drug therapy ; Dystonia ; drug therapy ; Humans ; Joint Dislocations ; drug therapy ; Sialorrhea ; drug therapy ; Temporomandibular Joint Disorders ; drug therapy

AIM To determine the relationship between the elevation of endogenous inhibitor of nitric oxide synthase (NOS)N G,N G-asymmetric dimethylarginine (ADMA) and metabolic control in diabetic rats. METHODS Diabetes was induced in Sprague-Dawley rats by a single intraperitoneal injection of streptozotocin. At 72 h after injection, half of diabetic rats received insulin treatment for 8 weeks (20 U?kg -1?d -1,ih, bid). Serum levels of ADMA were measured by high-performance liquid chromatography. Thoracic aortic rings from non-diabetic age-matched control, untreated diabetic, and insulin-treated diabetic rats were tethered in isolated organ baths,contracted with 1 ?mol?L -1 phenylephrine, and challenged with either the endothelium-dependent vasodilator acetylcholine or the endothelium-independent vasodilator sodium nitroprusside. Serum concentrations of glucose, glycosylated serum protein, and malondialdehyde, derived from lipid peroxidation were also examined to estimate metabolic control.RESULTS Serum levels of ADMA significantly elevated in untreated diabetic rats compared with control rats. This elevation of ADMA was accompanied by impairment of relaxation response to acetylcholine but not sodium nitroprusside in aortic rings. Chronic insulin treatment not only prevented the elevation of serum ADMA, but also improved the impaired endothelium-dependent relaxation in diabetic rats. Serum levels of glucose, glycosylated serum protein, and malondialdehyde were significantly increased in parallel with the elevation of ADMA in untreated diabetic rats compared with control rats. These parameters were normalized after diabetic rats received insulin treatment. CONCLUSION These results provide the first evidence that the elevation of endogenous inhibitor of NOS in streptozotocin-induced diabetic rats is close related to metabolic control of the disease.

Genome-wide association study (GWAS) has been increasing rapidly worldwide in recent years, along with more attention to heredity and genetic polymorphism of diseases.The single nucleotide polymorphism (SNP) is the most common genetic variant in the human genome, which can influence gene expression, transcription, translation and modification, and has become one of the important causes of disease susceptibility.Not only is uric acid related SNP susceptible to hyperuricemia and gout, but also plays an important role in the circulation, respiration, and nervous system diseases.Therefore, the present paper reviews the relationship between uric acid related SNP and clinical diseases in order to bring a new perspective on prevention and treatment.

The B-cell lymphoma gene 2 (Bcl-2) is considered as the most important inhibiting cell apoptosis control gene,and its expression is up-regulated in asthma.Drug intervention against Bcl-2 affects signal pathways,down-regulates the Bcl-2 expression,and induces programmed cell death.It may become the target of asthma treatment.This article reviews the structure characteristics of the Bcl-2,the mechanism of regulating apoptosis,and its role in asthma.

The data of 162 cases with acute schistosomiasis in Jingzhou City from 2004 to 2008 was analyzed, and the resultsshowed that the endemic situation of acute schistosomiasis decreased year by year, and the children aged 5-14 years were themain infection population, and swimming and playing in water was the main infection mode. It is suggested that health educationfor residents especially students should be strengthened to improve their conscious for disease prevention.

20?10 6/L were observed in the blood. No patients presented bone pain, fever, abnormal function of liver and kidney, and so on. Conclusions:Our results indicated that rhG-CSF is efficacious and safe in auto-PBSCT for patients with plasma cell diseases. Therefore, the expense of hospitalization would be reduced significantly.