In recent years, w ith the w idespread use of advanced neuroimaging techniques and the aging of the population, more and more asymptomatic smal unruptured intracranial aneurysms (sUIAs) are incidentaly detected in clinical practice. Studies have show n that the prevalence of unruptured intracranial aneurysm (UIA) is 2%-3% in adults, and more than 2/3 of them are smal aneurysms of < 7 mm in diameter. Usualy these sUIAs do not have any symptoms and the risk of rupture is low er. They are also know n as incidental or asymptomatic aneurysms, but they are not w ithout the risk of rupture. At present, there is no unified opinion about w hether to conduct conservative treatment or surgical clipping or endovascular interventional therapy. This article review s the latest research progress of sUIAs ( < 7 mm in diameter), hoping to provide more evidence for clinical assessment, decision -making, and individual treatment of this kind of aneurysms.

Objective:To find out the impacting factors in uncertainty by analyzing the measurement uncertainty in the determina-tion of irbesartan tablets by HPLC and provide the evidence for the measurement evaluation. Methods:A mathematic model for calcu-lating uncertainty was established, and every component in the uncertainty was assessed. Results:The expanded standard uncertainty for the HPLC determination was 2. 4%. Conclusion:The measurement uncertainty of the experiment is mainly caused by the measur-ing method.

Objective To explore the effect of dexmedetomidine(DEX)for blood pressure,heart rate(HR) and SpO2 levels during anesthesia inquiry in elderly hypertensive(HBP)patients.Methods 96 cases with HBP accepted surgery were selected,and were randomly divided into the observation group and the control group,each group in 48 cases,The patients in the observation group continuous pumped into the 4μg/mL of DEX during surgery, while the control group continuous pumped into 0.9% sodium chloride solution during surgery.Heart rate(HR),sys-tolic blood pressure(SBP),diastolic blood pressure(DBP),pulse oxygen saturation(SpO2 )of the two groups after room entrance(T0),after DEX infusion(T1),before intubation(T2),after 2min intubation(T3)and 10 min(T4)after intubation were recorded and compared,extubated time,spontaneous breathing recovery time,call time to eye opening and hospitalization time and the incidence of adverse reactions in two groups were recorded.Results The difference of HR SBP,DBP and SpO2 at T0 and T4 between the two groups was not statistically significant(all P >0.05);HR, SBP and DBP were significantly lower in the observation group than those in the control group at T1,T2,T3(all P <0.05).There were no significant changes of SpO2 in the patientˊs after the room entrance;extubated time,spontaneous breathing recovery time,call time to eye opening and hospitalization time in the observation group were significantly lower than those in the control group(t =8.874,9.073,8.573,all P <0.05).The adverse reactions rate in the observation group was 4.2%,which in the control group was 6.3%,the difference was not statistically significant(P >0.05). Conclusion Continuous pumped DEX has a significant sedative effect in elderly HBP patients during surgery,and does not produce respiratory depression,can help elderly patients with HBP smoothly pass the perioperative period.

Objective To explore the correlation of infants with asthma and food allergens,to povide the basis for early prevent the development of asthma.Methods The U-niCAP-100 automatic detection system was used to check the common food allergens in serum of 79 infants with asthma and 68 healthy children of the same age.Results The positive rate of serum total IgE in the group of asthma was 64.6％,significantly higher than the healthy group (45.6％)(P＜0.01).The positive rate of serum SIgE was showed that:the mainly food allergens of the asthma group was milk(63.2％)and whole egg(26.3％)which were,significantly higher than the healthy group(36.8％,14.7％)(P ＜ 0.01 and P ＜ 0.05).Conclusion Asthma of infant had close relation with the food allergens.Early avoid food allergens had an important role in preventing the development in low-age children with asthma.

Objective To analyze the clinical value and safety of capsule endoscopy in the digestive tract diseases.Methods 55 cases of inpatients or outpatients were given the capsule endoscopy examination.The positive detection rate and safety were observed.Results The positive detection rate was 87.3％,the diagnostic rate was 50.9％.Capsule retention in the body happened in 2 cases (1 case of small intestine space-occupying lesions,decided to take the operation,another 1 case got Crohn's disease,intestinal incomplete obstruction),the occurrence rate was 1.5％.Conclusion The capsule endoscopy make up some shortcomings of the traditional gastrointestinal endoscope,but also show some drawbacks,so improving performance of instrument of the capsule endoscopy,expanding the scope of application of capsule endoscopy will be the development direction of the capsule endoscopy in the future.

Patients are exposed to both the internal radiation from radiopharmaceutical and the external radiation from the X-rays during PET/CT examination. Estimating patients′ radiation dose from whole body PET/CT examination could eliminate their apprehension and give clinical physicians guidance about whether the patients need to perform PET/CT examination. The calculation methods, influencing factors, cancer risk of PET/CT imaging and how to reduce the radiation dose are reviewed in this paper.

Objective To investigate the effect of Tianqi Jiangtang capsules combined with metformin on blood viscosity, cognitive disorder in elderly patients with type 2 diabetes mellitus complicated with cerebral microvascular lesions.Methods 76 patients with type 2 diabetes mellitus complicated with cerebral microvascular lesions were divided into the observation group and the control group according to odd and even numbers, 38 cases in each group.The observation group were given Tianqi Jiangtang capsules combined with metformin while the control group were received metformin alone.The clinical curative effect, adverse reactions were compared between the two groups.The total score of TCM symptoms, blood glucose, blood lipid, high-sensitivity C reactive protein(hs-CRP), hemorheology and Mini Mental State Examination(MMSE)scores were determined before and after treatment.Results The total effective rate in the observation group(89.47%)was significantly higher than that in the control group(71.05%)(P< 0.05);After treatment, the total score of TCM symptoms, FPG, 2 h PG, hs-CRP, TC, TG, LDL-C, whole blood viscosity at high shear, whole blood viscosity at low shear, plasma viscosity and hematocrit were significantly lower than those before treatment, while MMSE scores were significantly higher(P< 0.05), and the above indexes in the observation group after treatment were significantly better than those in the control group(P< 0.05).There were no significant adverse reactions in the 2 groups.Conclusion Tianqi Jiangtang Capsules combined with metformin is safe and effective in the treatment of elderly patients with type 2 diabetes mellitus complicated with cerebral microvascular lesions.It can significantly improve lipid metabolism and hemorheology, reduce blood viscosity, and alleviate cognitive disorder.

Objective:Using Monte Carlo simulation method to study the important dosimetric parameter output factor of the LUNA stereotactic body radiotherapy device. Methods:Following the manufacturer’s technical documentation to establish the LUNA stereotactic body radiotherapy device’s Monte Carlo model and after model validation. After referring to the output factor measurement’s detector provided by manufacturer, set the relevant parameters in Monte Carlo model at last, compare and analyze the difference of output factor which provided between by manufacturer and calculated by Monte Carlo simulation. Results:In the range of 3%deviation, under the different collimator of condition, output factors which provided by manufacturers and calculated by Monte Carlo are in good agreement, and the reasons for the difference are also analyzed. Conclusion:LUNA stereotactic body radiotherapy device’s output factors of Monte Carlo simulated research work provides reference and basis for the clinical use and quality control.

Objective To investigate pathologic changes and method of magnetic microsphere(Fe3O4) embolization for tumor.Methods 18 cases with tumors were treated by embolized using Fe3O4 under fluoroscopy through catheters by Seldinger’s technique,pathological examinations were done in 15 cases before operation,including primary hepatic carcinoma in 8,renal carcinoma in 6,renal myolipoma in 3 and breast carcinoma in 1.Results Pathological examination after embolism showed that necrosis of neoplastic tissue was 100 percent.Conclusion Fe4O4 is a good embolic substance for treating tumors and there is no damage to the other tissues.

Objective To investigate the clinical applied value of magnetic mitomycin microspheres and magnetic Fe 3O 4 in treating tumors and vascular diseases by embolism.Methods The embolic therapy in 106 cases useing microspheres or drugs of Fe 3O 4 under TV-guided through catheterization using Seldinger's technique were performed.Results In 94 malignant tumors and 12 benign vascular diseases.The most of tumors became small remarkably on CT,USG or BSA one month later after embolism.Pathology showed that necrosis of cancer tissue was 100 percent.Examination of blood biochemistry showed that the functions of liver and kidney had some changes,however these functions could recover to normal or better after therapy.AFP decreased significantly after embolism in most primary hepatic cancer.Changes in density of serum Fe before and after embolism showed that embolism of Fe 3O 4 microspheres could maintain serum Fe in normal condition.DSA showed that microspheres of Fe 3O 4 were moved from the near portion to the peripheral embolic arteries after embolism one month later and the clinical symptoes improved.Conclusion Fe 3O 4 is good embolic substance and can avoid some complications by embolism.