1.Analysis of Correlation between the Number of Macrophages in Deep Burn Wound and the Concentrations of sTNFR and sVCAM-I in Wound Fluid
Journal of Shanghai Jiaotong University(Medical Science) 2006;0(08):-
Objective To detect the concentrations of (soluble TNF receptor type,sTNFR-I, sTNFR-II) and (soluble vascular cell adhesion molecule-1,sVCAM-I) in deep burn wound fluids and the number of macrophages in different stage of human deep burn wound, and to analyse the correlation between them. Methods The wound fluid was collected with sponge during the dressing change, and then the concentrations of sTNFR-I, sTNFR-II and sVCAM-I were detected by ELISA. The tissues of burn wound were collected at operation, and the tissue slices were dyed with HE.The macrophages were marked by immunohistochemistry with antibody of CD68, and then the number of macrophages was counted under the microscope. Results The concentrations of sTNFR-I and sTNFR-II in burn wound fluid and the number of macrophages in burn wound were significantly increased two days postburn, which maintained at high levels until the wound healed. The concentration of sVCAM-I was decreased immediately after the burn until the wound healed. The correlation coefficient between the concentrations of sTNFR-I, sTNFR-II, sVCAM-I and the number of macrophages were 0.95, 0.97 and -0.37, respectively. Conclusion The number of macrophages has a strong correlation with sTNFR-I and sTNFR-II in human deep burn wound, and has a weak correlation with sVCAM-I,which suggests that the macrophages may play a cooperative role with sTNFR in burn wound healing.
2.Changes of interlukin-8 in burn wound fluid
Journal of Shanghai Jiaotong University(Medical Science) 2006;0(08):-
21 d groups,respectively. Conclusion IL-8 plays an important role in burn wound healing as a chemotactic factor.
3.Type 2 diabetes in MKR transgenic mice caused by skeletal muscle-specific double deficiency of IGF-1 and insulin receptors
Rong YU ; Xihua CHENG ; Wei HU
Chinese Journal of Diabetes 2008;0(07):-
Objective To examine the circulating glucose and body weight in the transgenic MKR mouse model who expressed dominant-negative IGF-1 receptor and insulin receptor in skeletal muscle leading to systemic insulin resistance and diabetes. Methods MKR mice were genotyped by PCR analysis of tail DNA.And in these mice we examined the circulating glucose and body weight once a week from 1 to 16 weeks of age, and the circulating insulin and glucose tolerance at age of two-month-old by using C57 mice as controls. Results The descendents of MKR mice kept hereditary feature. And these mice had hyperglycaemia from 3 weeks of age,and an increasing body weight slowly(P
4.Report of a case with Schwardz-Jampel syndrome.
Rong QIANG ; Hui-ping SHI ; Wei YU
Chinese Journal of Pediatrics 2003;41(6):456-456
Child
;
Humans
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Karyotyping
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Male
;
Osteochondrodysplasias
;
classification
;
diagnosis
;
genetics
7.Characteristics and strategies of novelty assessment of literature on information technology
Wei WANG ; Wenhui RONG ; Na LI ; Xiangchun JIA ; Yu ZHANG
Chinese Journal of Medical Library and Information Science 2013;(12):67-69
After a description of the characteristics of novelty assessment of literature on information technology involving different subjects, multiple new technologies and deep knowledge, the strategies were elaborated for it.
8.Comparison of the clinical manifestation and lung function between RSV and hMPV lower respiratory tract infection.
Wei JI ; Zheng-rong CHEN ; Yu-qing WANG
Chinese Journal of Pediatrics 2009;47(1):71-73
Child, Preschool
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Humans
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Infant
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Infant, Newborn
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Lung
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physiopathology
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virology
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Male
;
Metapneumovirus
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isolation & purification
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Paramyxoviridae Infections
;
diagnosis
;
physiopathology
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Respiratory Function Tests
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Respiratory Syncytial Virus Infections
;
diagnosis
;
physiopathology
;
Respiratory Syncytial Viruses
;
isolation & purification
9.Effect of Mepilex on pressure sores in patients lying at lateral position after craniocerebral surgery
Rong MIAO ; Hua YU ; Yuejiao SU ; Dan LIAO ; Nanmo WEI
Modern Clinical Nursing 2017;16(2):60-62
Objective To investigate the effect of Mepilex on pressure sores in patients at lateral position after craniocerebral surgery.Methods Toally 60 patients lying at lateral position after craniocerebral surgery were randomized into two groups in equal number with random digit table:the control group and experiment group.In the control group,Gel pad was used to prevent and treat the pressure sores and in the experiment group Mepilex was used between the compressed skin and operation table before setting the position.The skin conditions of the two groups were observed after operation.Result The prophylactic effect of pressure sore in the experiment group was significantly better than that in the control group (P<0.05).Conclusion Mepilex can prevent the skin pressure sores in the patients at lateral position after cerebral surgery.
10.Type 2 diabetes in MKR transgenic mice cansed by skeletal muscle-specific double deficiency of IGF-1 and insulin receptors
Rong YU ; Xihua CHENG ; Wei HU ; Kaichun WEI ; Yubing GUO ; Junli LIU
Chinese Journal of Diabetes 2008;16(7):438-440
Objective To examine the circulating glucose and body weight in the transgenic MKR mouse model who expressed dominant-negative IGF-1 receptor and insulin receptor in skeletal muscle leading to systemic insulin resistance and diabetes. Methods MKR mice were genotyped by PCR analysis of tail DNA.And in these mice we examined the circulating glucose and body weight once a week from 1 to 16 weeks of age, and the circulating insulin and glucose tolerance at age of two-month-old by using C57 mice as controls. Results The descendents of MKR mice kept hereditary feature. And these mice had hyperglycaemia from 3 weeks of age,and an increasing body weight slowly(P<0.01).Twenty-fold significant hyperinsulinemia was observed in MKR mice,and they were glucose intolerant in 2-month-old male and female (P<0.01).Conclusions The MKR mouse is an excellent model of type 2 diabetes