1.Analysis and investigation of health status among 1661 elderly people in a rural area
Cuifang NIE ; Zhen DONG ; Xiuxia HAN ; Kun YU ; Aiguo MA
Chinese Journal of Disease Control & Prevention 2008;0(06):-
85 cm) before 65 years old and descended after 65 (P
2.Exercise activities are impaired in maintenance dialysis patients and its correlative factors
Han LI ; Kun ZHANG ; Xiaojing WANG ; Aili WANG ; Chen YU
Chinese Journal of Nephrology 2016;32(6):412-417
Objective To investigate the exercise performance in maintenance dialysis patients,and analyze its correlative factors.Methods Maintenance dialysis patients admitted in Tongji Hospital of Shanghai from December 2014 to March 2015 were enrolled,with their baseline data and biochemical measurement being collected.The anthropometric indexes including arm circumference,triceps skinfold,waist circumference and hip circumference were detected.The exercise activity was assessed by hand grip test,timed up and go test (3mTUG) and five times sit-to-stand test (FTSST).Patients were divided into fast group (3mTUG≤12 s) and slow group (3mTUG > 12 s).Univariate and multivariable analyses were used to evaluate the factors influencing exercise performance in maintenance dialysis.Results There were 121 patients enrolled:62 on peritoneal dialysis and 59 on hemodialysis,76 men and 45 women.Patients' average age was (61.6± 13.0) years and median dialysis age was 31.7(12.3,69.0) months.There was no statistical difference between fast group (n=80) and slow group (n=41) in gender,dialysis method,dialysis age,body mass index (BMI),arm muscle area (AMA),waist-hip ratio (WHR),hemoglobin (Hb) and total cholesterol (TC).Patients in fast group were younger,had higher serum albumin,prealbumin,serum phosphate and iPTH,and less prevalence of diabetes than those in slow group.In exercise activity,patients in fast group had better performance in handgrip,3mTUG and FTSST (all P < 0.05).Univariate analysis showed that,handgrip was correlated with sex (male),AMA,BMI,age,diabetes,serum phosphorus and TC;scores in FTSST was correlated with age,BMI,diabetes,WHR,dialysis method,dialysis age,prealbumin and serum phosphorus;scores in 3mTUG was correlated with age,diabetes,WHR,dialysis method and dialysis age,prealbumin,serum phosphorus and iPTH (all P < 0.05).Multiple stepwise regression analysis showed that sex (male),age,AMA and diabetes were independently correlated with handgrip in dialysis patients (all P < 0.05);age,dialysis method,BMI and diabetes were independently correlated with scores in FTSST (all P < 0.05);age,dialysis method,diabetes and WHR were independently correlated with scores in 3mTUG (all P < 0.05).Conclusions The exercise performances of patients on maintenance dialysis are impaired.Age and diabetes are independent factor associated with the exercise performances of patients on maintenance dialysis.AMA is independently associated with upper limb movement,and dialysis method,BMI and WHR are independent factors associated with lower limb movement in dialysis patients.
3.Congenital lower limb lymphedema in a neonate.
Bei-yan ZHOU ; Guang-jin LU ; Yu-kun HAN
Chinese Journal of Pediatrics 2009;47(1):78-78
Humans
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Infant, Newborn
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Lower Extremity
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pathology
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Lymphedema
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congenital
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Male
4.Metastasis correlation factors expression and NF-?B activation in colorectal carcinoma
Kun YU ; Mei HAN ; Jinkun WEN ; Binghui LI
Basic & Clinical Medicine 2006;0(04):-
Objective To investigate the relationship between NF-?B activation and the expression of metastasis correlation factors.Methods The expression of NF-?B,COX-2,ICAM-1,VCAM-1 and MMP9 in colorectal cancer and normal tissues was detected using Western blotting.Results(1)The expression level of NF-?B was higher in cancer tissues than that in normal tissues(P
5.Construction of the Recombinant hpAKP Retrovirus Vector and its Expression in Newborn Mouse Brain
Chinese Journal of Contemporary Pediatrics 2001;3(1):22-24
Objective To explore the possibility of using the retrovirus vector (RV) in the gene therapy of neonatal neuropathy and the expression properties of target genes in the brain. Methods We combined human placenta alkaline phosphatase (hpAKP) cDNA obtained from plasmid DAP with RV pLXSN and transferred recombinant plasmid into packed cell line PT67 by the liposome entrapment method. We injected high-titer recombinant hpAKP-RV into the 1-day-old mouse brain, and then determined the hpAKP expression in the brain by hybridation in situ and the enzyme histological chemistry method as well as the type of expression cells by the immunological histological chemistry method. Results The infected cells lay in the Ⅱ-Ⅴ stratum of the cerebral cortex, the nuclei of the brain stem, the Purkenje cell stratum of the cerebellum, the vascular wall, and the cerebral mater. The area of positive cells increased from the 1st to the 7th day after the injection, but was smaller on the 28th day than on the 7th day after the injection, part of those being GFAP(-). RV was not found harmful to the nervous system. Conclusions RV can transfer target genes into the newborn mouse brain effectively, including neurons. Target genes express normally. It is likely that RV could be used in the gene therapy of neonatal neuropathy.
6.The pathological findings and inflammatory responses in the lung tissue of neonatal rats following lipopolysaccharide treatment.
Xu-xu CAI ; Yue DU ; Xiao-hua HAN ; Yun-xiao SHANG ; Yu-kun HAN
Chinese Journal of Pediatrics 2003;41(8):617-618
Animals
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Animals, Newborn
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Bronchoalveolar Lavage Fluid
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chemistry
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cytology
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Female
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Lipopolysaccharides
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toxicity
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Lung
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drug effects
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enzymology
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pathology
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Male
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Neutrophils
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cytology
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Peroxidase
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analysis
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Rats
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Rats, Wistar
7.Factors influencing therapy decision in patients with severe pelvic organ prolapse
Yu WANG ; Junfang YANG ; Jinsong HAN ; Fuli ZHU ; Kun ZHANG ; Ying YAO
Chinese Journal of Obstetrics and Gynecology 2015;(2):112-115
Objective To investigate the factors influencing therapy decision of surgery or pessary in patients with severe pelvic organ prolapse (POP). Methods Totally 419 cases ofⅢtoⅣdegree POP patients were studied retrospectively. Patients were divided into surgery and pessary groups according to their own choice. Clinical characters were compared such as age, body mass index (BMI), age of onset and disease duration, POP stage, complications. Results 67.5%(283/419) patients were in the surgical group and 32.5%(136/419) patients in the pessary group. Patients in surgical group had higher BMI [(25.1 ± 3.5) versus (23.8±2.6) kg/m2], elder age of onset [(62±12) versus (57±11) years old], longer disease duration [(5± 8) versus (11±11) years] and higher POP staging of middle compartment and less cardiac disease [20.1%(57/283) versus 30.9% (42/136)] than those in pessary group, all had significant difference (P<0.05). Logistic regression analysis on the above factors showed a statistically significant difference between two groups, BMI, disease duration and POP staging of middle compartment were independent factors (OR=1.141, 0.932, 1.389;all P<0.01). Conclusions Patients with higher BMI, higher POP staging of middle compartment and less cardiac disease tended to choose surgery. Patients with younger age of onset and longer disease duration tended to choose pessary. Factors as age, POP staging of anterior and posterior compartment, history of POP surgery, complicated with hypertension and diabetes, showed no influence on treatment choice.
8.Analysis of an acute respiratory infection outbreak caused by adenovirus
Han ZHAO ; Qin LI ; Jiang LONG ; Yu XIA ; Kun SU ; Hua LING ; Yan FENG
Chongqing Medicine 2015;(4):506-508
Objective To analyze the investigation results of an acute respiratory infection outbreak caused by adenovirus and provide scientific information for the prevention and control of congener public health emergencies .Methods A case‐control study was performed with grades and gender as matching factor ,all cases and selected controls were investigated with the same question‐naire .Results A totul of 47 cases were diagnosed in the outbreak ,no death ,the attack rate was 8 .88% ;the main clinical symptom was fever and 27 .7% of the cases became pneumonia .The case‐control study analysis demonstrated that with close contact to cases or not(χ2 =7 .96 ,P<0 .05) ,contact time (χ2 =7 .95 ,P<0 .05) ,hand washing habits (χ2 =25 .92 ,P<0 .05) and with or without the habit of cleaning snivel by hand directly (χ2 =22 .78 ,P<0 .05) were statistically different between cases and controls .Conclu‐sion long‐time contact to cases maybe the main risk factor for the adenovirus infection ,especially the contact manner were sharing the same desk or playing together .A good health habit of washing hands often and no cleaning snivel by hand directly were impor‐tant protective factors .Thus ,strengthening the training of health habit and awareness is the important preventive measure for re‐spiratory infectious diseases .
10.Neonatal hepatoblastoma--a case report.
Zhao-hong CHEN ; Guang-jin LU ; Yu-kun HAN ; Wei-dong LI ; Zhi-jun WU
Chinese Journal of Pediatrics 2005;43(8):631-632