OBJECTIVE:To improve the testing method of the related substances in nifedipine sustained-release tablets (Ⅰ).METHODS:The chromatographic condition was in line with the "State Drug Standard".In computing the contents of foreign substances,the standard of "it is negligible if the peak area of foreign substances was less than 10% of the peak area of Nifedipine in the standard solution" was improved to be "it is negligible if the peak area of foreign substances was less than 2%of the peak area of Nifedipine in the standard solution".RESULTS:The contents of the foreign substances determined in accordance with the "National Drug Standard" weresignificantly different from those determined by the improved method (0.00%,0.08%,0.29%,0.14 % vs.0.10%,0.21%,0.51%,0.27%,respectively).CONCLUSION:The improved method can help improve the standard drug quality in that the contents of the foreign substances can be strictly kept under control.

Adolescent ; Child ; Child, Preschool ; Chronic Disease ; Cough ; diagnosis ; drug therapy ; etiology ; Female ; Humans ; Male ; Rhinitis ; complications ; diagnosis ; drug therapy ; Sinusitis ; complications ; diagnosis ; drug therapy

Objective To investigate the morbidity rate and risk factors of post-stroke depression in middle-aged and elderly per-sons with the stroke .Methods From March 2011 to March 2012 ,68 cases of stroke patients were followed up for 6 months after the first stroke .Hamilton Depression Scale-17 ,Activity of Daily Living Scale ,Eysenck Personality Questionnaire ,Scores of Neuro-logical Deficit and Family APGAR Index were used to investigate the morbidity rate and risk factors of PSD in 6 months after the attack of stroke .Results The morbidity rate of PSD was 36 .76% (25/68) in 6 months after the first stroke .Logistic regression a-nalysis indicated that the morbidity rate of PSD was without a clear relationship with age ,whether or not combined with basic disea-ses ,personality ,daily life ability and neurologic impairment .It was closely related with stroke position ,gender ,economy and family care .Conclusion The morbidity rate of PSD is considerable and the major risk factors of PSD are female ,left brain stroke ,poor e-conomic condition and lack of family care .

Objective To explore the clinical effect of atomoxetine on children with attention deficit hyperactivity disorder(ADHD)comorbid tic disorder.Methods The children who met the criteria of Mental Disorders Diagnostic and Statistical Manual diagnostic criteria for ADHD and tic symptoms were given systematic atomoxetine titration reaching the optimum dose.ADHD and tic symptoms were evaluated with ADHD rating scale-Ⅳ(ADHD-RS-Ⅳ)for parents Yale Global Tic Severity Scale(YGTSS),respectively.Results Twenty children with ADHD comorbid tic disorder [17 male,3 female;age range 7.58-17.0 years,mean age(10.55?2.58)years] completing systemic titration was enrolled in the study,including 10 subjects with ADHD-inattentive type,9 mixed type,and 1 hyperactive/impulsive type.The mean optimal dose was(1.19?0.21)mg/(kg?d).The total score(12.65?9.08)scores,inattention score(7.45?4.75)scores and hyperactivity/impulsivity score(3.0)of ADHD-RS-Ⅳ decreased significantly post-treatment compared with pro-treatment(31.10?8.52,17.60?3.09,and 13.0 scores,respectively,P

OBJECTIVE:To observe the clinical efficacy and safety of saxagliptin combined with metformin in the treatment of type 2 diabetes. METHODS:A total of 95 patients with type 2 diabetes were randomly divided into observation group(47 cases) and control group(48 cases). All of the patients received Metformin hydrochloride sustained-release tablets 0.5 g for continuous 4 weeks,orally,3 times a day;based on the treatment,control group was continuously given Metformin hydrochloride sustained-re-lease tablets 0.5 g for continuous 24 weeks,orally,3 times a day;observation group was given Saxagliptin tablets 5 mg continu-ous 24 weeks based on the treatment of control group,orally,once a day;the treatment course was 28 weeks. The clinic data was observed,including clinical efficacy,FPG,2 h PG,bed time glucose,HbA1c,BMI before and after treatment,incidence of hypoglyce-mia,severe hypoglycemia and adverse reactions. RESULTS:The total effective rate in observation group was higher than control group,the incidence of hypoglycemia in observation group was lower than control group(P<0.05). After treatment,the glucose in-dexes in 2 groups was significantly lower than before,and FPG and HbA1c in observation group were lower than control group(P<0.05). There were no significant differences in the BMI before and after treatment,incidence of severe hypoglycemia and adverse reactions between 2 groups(P>0.05). CONCLUSIONS:Saxagliptin combined with metformin has better efficacy and safety than metformin alone in the treatment of type 2 diabetes,and can significantly reduce the incidence of hypoglycemia.

Currently, multimedia teaching plays a more and more important role in colleges.However, the negative effects of multimedia teaching have gradually revealed because of the neglection of its limitations. In this article, strategies were proposed from three different aspects against disadvantages of multimedia teaching in colleges in order to improve its role more effectively.

Adult ; Coal Mining ; Dermatitis, Occupational ; epidemiology ; Humans ; Male ; Middle Aged ; Prevalence

Apolipoprotein C3 (APOC3) is a multifunctional protein.Its concentration is positively correlated with triglyceride (TG) levels and is an independent risk factor for coronary heart disease (CAD) prediction and development.Recent studies showed that APOC3 could not only regulate triglyceride-rich lipoproteins (TRL) metabolism,but also regulated endothelial function,that is,it could induce endothelial dysfunction and disorders of lipid metabolism.Gradually,APOC3 induces atherosclerosis (AS),increases the risk of the occurrence of CAD and other related diseases.APOC3 polymorphisms are also closely related to related diseases.

Objective To elucidates the regulation of Notch1 activity by Rab5 which controls endosome fusion.Methods Rab5 expression of BxPC3 cells were inhibited by siRNA interference,the changes of Notch ICD protein were measured by Western blot.We use Wortmannin and LY294002 which inhibit the acticity of Phosphatidylinositol(PI) 3-kinases to investigate Notch ICD protein level.Results After inhibiting Rab5 expression or the activity of Phosphatidylinositol(PI) 3-kinases,Notch ICD protein level and the growth of BxPC3 cells decreased.Conclusion In BxPC3 cells,Rab5 and Phosphatidylinositol(PI) 3-kinases are important to regulate Notch1 activity and the activation of Notch is dependent on endocytosis.