Pelvic exenteration,first line salvage therapy for selected recurrent cervical cancer patients,is accompanied by a high operative mortality and loss of structure and function of pelvic organs.Advances in radiation therapy,especially 3-dimensional brachytherapy and stereotactic body radiotherapy,provide the opportunity to achieve similar efficacy of pelvic exenteration with acceptable complications and protect the structure and function of pelvic organs.

Academic Dissertations as Topic ; Bibliometrics ; China ; Oral Medicine ; statistics & numerical data

MicroRNAs(miRNAs) are small mm-coding RNA molecules that post-transcriptionul-ly regulate gene expression. Advanced studies show that miRNA are involved in cancer. Even some scientists regard miRNAs as oncogenes or tumor associated genes. This review tries to have a brief introduction on the progress in the relationship between miRNAs and tumor's formation,development,diagnosis,therapy and prognosis in humans.

Caspase 3 ; metabolism ; Child ; Female ; Glomerulonephritis, Membranous ; enzymology ; etiology ; pathology ; virology ; Hepatitis B ; complications ; pathology ; Hepatitis B virus ; Humans ; Male

Fatal Outcome ; Female ; Heart Defects, Congenital ; diagnosis ; Humans ; Infant ; Male ; Pulmonary Artery ; abnormalities ; Tomography, X-Ray Computed

OBJECTIVETo compare clinical efficacy of individual osteotomy instrument and total knee arthrolplasty (TKA) in treating patients with knee osteoarthritis.

METHODSFrom June 2014 to December 2014, 40 patients with unilateral knee osteoarthritis were randomly divided into two groups and 20 cases were in each group. One group (individual group) were treated with TKA with individual osteotomy instrument,including 5 males and 15 females with an average age of (67.3 ± 6.5) years old; 8 cases on the left side and 12 cases on the right side. Another group (conventional group) were treated with conventional TKA , including 6 males and 14 females with an average age of (66.8 ± 7.3) years old; 9 cases on the left side and 11 cases on the right side. Operative time, blood loss, postoperative HSS score at 6 months, and changes of mechanical alignment before and after operation were analyzed.

RESULTSOperative time in individual group was (79.3 ± 4.7) min, and (83.5 ± 3.2) min in conventional group; blood loss in individual group was (287.1 ± 24.9) ml and (363.4 ± 47.2) ml in conventional group, there were statistical differences between two groups in these two items. There was no significant difference in postoperative HSS score at 6 months between individual group (84.8 ± 3.2) and conventional group (84.2 ± 2.5). Postoperative limb alignment in individual group was (2.8 ± 0.6)°, and (2.8 ± 0.6)° in conventional group, with no significant difference between two groups.

CONCLUSIONTKA with individual osteotomy instrument could reduce operative time and blood loss, but there was no differences in knee function, changes of mechanical alignment compared with TKA.

Adult ; Aged ; Arthroplasty, Replacement, Knee ; methods ; Case-Control Studies ; Female ; Humans ; Knee Joint ; surgery ; Male ; Operative Time ; Osteoarthritis, Knee ; surgery ; Osteotomy ; instrumentation ; methods ; Treatment Outcome

Objective To investigate the effect of two kinds of permeation enhancers,azone and clove bud oil,on transdermal permeation of Shuxiong cataplasm. Methods Cataplasm containing azone and clove bud oil,at different concentrations were prepared,with ferulic acid as the index,the role of enhancing permeation of azone and clove bud oil for the main active component were studied by in vitro permeation experiments. Results Both azone and clove bud oil at different concentrations could increase permeation. Clove bud oil was better than azone and the best concentration of Clove bud oil is 3%. Meanwhile,the permeation enhancing multiple of clove bud oil group was the highest which was 3.68. Conclusion With the cumulative permeation quantity of ferulic acid as the index,3% clove bud oil is more suitable to act as a permeation enhancer of Shuxiong cataplasm.

OBJECTIVE To study the dynamic changes of drug resistance and infectious distribution of Pseudomonas aeruginosa and guide drug treatment in clinic.METHODS The susceptibility to 12 antibiotics were detected in 758 P.aeruginosa strains.RESULTS The resistance of P.aeruginosa to 12 antibiotics was increased in the past four years.The resistant rate to imipenem and amikacin was below 25%.The infection caused by P.aeruginosa happened frequently in Department for Cadre,Intensive Care Units(ICU) and Department of Respiration.Among 758 strains of P.aeruginosa,87 strains were identified multi-drug resistant and found more frequently in Department for Cadre,ICU,Department of Respiration and Department of Burn.CONCLUSIONS The drug resistance of P.aeruginosa has become a more serious problem than before.The monitor of drug-resistant P.aeruginosa could guide treatment and provided epidemiologic and dynamic changes data for clinic.The infection of multi-drug resistant P.aeruginosa meets most frequently in patients who received antibiotic treatment for a long time and had a long stay in the hospital.

Objective To explore the effect of budesonide(BUD) on dendritic cell(DC) and airway inflammation in the asthmatic mice.Methods Forty female Kunming mice were divided into 4 groups:asthmatic model group,therapeutic control group,BUD treated group,and normal control group,with 10 mice in each group.Mice were sensitized by an intraperitoneal injection of 50 ?g ovalbumin(OVA) adsorbed to 1 mg aluminum hydroxide dissolved in 0.2 mL saline.Animals were boosted on the 14th day in the same way.From the 21th to 35th days,and mice were challenged with 10 g/L aerosolized OVA for 30 min a day to establish a murine model of asthma.To evaluate the effect of BUD,60 minutes prior to OVA exposure,the mice were treated with 1 mg aerosolized BUD or placebo(saline).Control animals were sensitized intraperitoneally with saline and challenged with aerosolized saline alone.Eosinophil(EOS) count,degree of mucus secretion and DC count around the airways were measured by haematoxylin and eosin staining,periodic acid schiff's staining,immunochemistry technique and computerized image analysis system.Results In asthmatic model group,EOS count,DC count and the degree of mucus secretion around the airways were increased compared with nomal control group(P_a0.05).In BUD treated group,EOS count,DC count and the degree of mucus secretion around the airways were decreased compared with the asthmatic model group(P_a