1.Nosocomial Infection in Psychiatry Department: A Clinical Investigation and Analysis
Chinese Journal of Nosocomiology 1994;0(01):-
OBJECTIVE To explore the incidence of the nosocomial infection in patients with mental diseases,(analyze) the correlative factors and then reduce the incidence.(METHODS) By using the retrospective method,the(inpatient) cases in psychiatry department from Jan 2000 to Dec 2004 were surveyed and statistically analyzed.(RESULTS) There were 313 cases of nosocomial infection from 9 089 inpatients with mental diseases.The infection rate was(3.44%.) The total rate had been dropped year by year.The major sites of the infection were the(upper)(respiratory) tract(34.82%),the gastrointestinal tract(20.45%) and the urinary system(18.53%).The(infection) rate in ladies patient area(3.83%) was significantly higher than that of gentlemen patient area(3.07%)(P
2.Progress in research on DNA methylation and laryngeal carcinoma.
Chinese Journal of Pathology 2011;40(1):67-70
Acid Anhydride Hydrolases
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genetics
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metabolism
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Animals
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Antimetabolites, Antineoplastic
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pharmacology
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Azacitidine
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analogs & derivatives
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pharmacology
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Biomarkers, Tumor
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analysis
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Carcinoma, Squamous Cell
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diagnosis
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genetics
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metabolism
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pathology
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Cyclin-Dependent Kinase Inhibitor p16
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genetics
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metabolism
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DNA Methylation
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drug effects
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Genes, p16
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Humans
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Laryngeal Neoplasms
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diagnosis
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genetics
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metabolism
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pathology
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Neoplasm Proteins
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genetics
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metabolism
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Tumor Suppressor Proteins
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genetics
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metabolism
3.Application of PACS system in medical imaging examination
Jing LIU ; Shiyuan LIU ; Hong YU
Chinese Journal of Medical Library and Information Science 2014;(4):73-75
After the advantages of PACS system in medical imaging examination were described, its rational appli-cation in medical imaging examination was elaborated .
4.Detection of basic fibroblast growth factor receptor protein on human lens epithelial cells
International Eye Science 2008;8(8):1511-1513
· AIM: To study the expression of basic fibroblast growth factor (bFGF) receptor protein in human lens epithelial cells (HLECs). METHODS: Immunohistochemistry was used to detect the level of bFGF receptor protein and image analysis was adopted to perform the relative quantitative analysis on it. · RESULTS: There was bFGF receptor protein in HLECs accordingl to both qualitative and quantitative analysis. · CONCLUSION: bFGF receptor protein exists in HLECs and it is the material foundation for bFGF to improve the proliferation of HLECs.
5.Lead compound optimization strategy (4)--improving blood-brain barrier permeability through structural modification.
Yu HONG ; Yu ZHOU ; Jiang WANG ; Hong LIU
Acta Pharmaceutica Sinica 2014;49(6):789-99
Blood-brain barrier is a natural protection for human body. It protects central nervous system from the interruption and damage of xenobiotics. However, it prevents potential drugs aimed at central nervous system, thus becomes an obstruction for the development of central nervous system drugs. The recent development of blood-brain barrier permeability research and several lead optimization strategies to improve blood-brain barrier permeability are reviewed. These structure optimization methods include increasing lipophilicity, reducing hydrogen bond doners, simplifying molecule, increasing rigidity, lowering polar surface area, avoiding acid group, prodrug strategy, modifying into active transporter's substrates, as well as avoiding P-glycoprotein recognized structures.
6.Lead compound optimization strategy (4)--improving blood-brain barrier permeability through structural modification.
Yu HONG ; Yu ZHOU ; Jiang WANG ; Hong LIU
Acta Pharmaceutica Sinica 2014;49(6):789-799
Blood-brain barrier is a natural protection for human body. It protects central nervous system from the interruption and damage of xenobiotics. However, it prevents potential drugs aimed at central nervous system, thus becomes an obstruction for the development of central nervous system drugs. The recent development of blood-brain barrier permeability research and several lead optimization strategies to improve blood-brain barrier permeability are reviewed. These structure optimization methods include increasing lipophilicity, reducing hydrogen bond doners, simplifying molecule, increasing rigidity, lowering polar surface area, avoiding acid group, prodrug strategy, modifying into active transporter's substrates, as well as avoiding P-glycoprotein recognized structures.
ATP-Binding Cassette, Sub-Family B, Member 1
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metabolism
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Biological Transport
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Blood-Brain Barrier
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Central Nervous System
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drug effects
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Central Nervous System Agents
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pharmacokinetics
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Drug Design
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Humans
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Permeability
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Xenobiotics
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adverse effects
8.Correlation Research on the Essence of Viscera-state and Neuro-Endocrine-Immune Network-related Indicators
Yu LIU ; Hong XIANG ; Libin ZHAN
Chinese Journal of Information on Traditional Chinese Medicine 2014;(7):18-21
Objective To explore the intrinsic link between neuro-endocrine-immune (NEI) network and the viscera-state.Methods Using three databases namely TCM database, Chinese pharmacy database and combination of TCM and WM database in China Academic Journals Database, the authors searched and collected NEI-related indicators published on journals for the viscera-state researches. Then a related database was established for data mining. Through analysis of association rules, analysis of the relationship among diseases, syndromes, therapeutic principles, combination of disease and syndrome, and NEI network related indicators were performed for association rules and directional network diagrams.Results Through the association analysis, the authors drew 44 directional network diagrams of high-frequency disease positions, syndromes, therapeutic principles and NEI network related indicators, and obtained 19 association rules. Kidney and liver essence research focused on HPG axis, HPA axis, and HPT axis. Spleen essence research focused on brain-gut peptide related indicators. Heart essence research focused on vascular endothelium function indicators. Pulmonary essence research focused on humeral immunity, ET and TNF-α.Conclusion It was feasible to explore the intrinsic link between NEI network and the viscera-state by using data mining. Differences among study on NEI network of five-organs systems were found, which is of great significance for researches on the essence of the viscera-state.
9.Hand hygiene intervention to reduce healthcare-associated infection rate in an intensive care unit
Huiying YANG ; Hong YU ; Yinmei LIU
Chinese Journal of Infection Control 2014;(10):612-615
Objective To investigate the influence of health care workers’(HCWs)hand hygiene intervention in healthcare-associated infection(HAI)in an intensive care unit(ICU).Methods Intervention measures of hand hygiene were adopted,effective supervision and management systems were established,hand hygiene compliance and HAI rate be-fore intervention(January-December 2012)and after intervention (the first stage:January-June 2013;the second stage:Ju-ly-December 2013)were compared.Results A total of 4 066 patients were surveyed,HCWs’hand hygiene compliance rate before intervention was 50.03%,the first and second stage after intervention was 61.80% and 64.57% respectively,there was increasing trend (rs=1.00,P<0.001).HAI before intervention was 5.48%,the first and second stage after inter-vention was 3.86% and 3.30% respectively,there was decreasing trend (rs=-1.00,P<0.001).Significant decreasing trends were found in rates of catheter-related bloodstream infection(CRBSI),catheter-associated urinary tract infection (CAUTI)and ventilator-associated pneumonia(VAP)(rs=-1.00,P<0.001).There were negative correlations between hand hygiene compliance rate and the infection rate of ICU,infection rate of CRBSI,CAUTI and VAP (P<0.05 ). Conclusion The improvement of hand hygiene compliance can effectively reduce the incidence of HAI in ICU ward.
10.Risk factors for healthcare-associated infection in a neonatal intensive care unit
Hong YU ; Yinmei LIU ; Huiying YANG
Chinese Journal of Infection Control 2017;16(3):233-236
Objective To understand the occurrence and risk factors of healthcare-associated infection(HAI) in a neonatal intensive care unit(NICU).Methods Neonates who were admitted to the NICU of a hospital from January 2012 to December 2014 were investigated retrospectively,risk factors for HAI were performed univariate analysis.Results A total of 760 neonates were included in the investigation,198 neonates developed 259 times of HAI,incidence of HAI was 26.05%,case incidence of HAI was 34.08%,incidence of HAI per 1 000 patient days was 9.50‰;the main infection site was lower respiratory tract (n =92,35.52%);among 259 cases of HAI,172 strains of pathogenic bacteria were isolated,the major pathogen was Acinetobacter spp.(n =40,23.26%);incidence of HAI was high in neonates with gestational age ≤32 weeks,birth weight≤1 500 g,length of hospital stay ≥10 days,duration of antimicrobial use≥10 days,mechanical ventilation,deep venous catheterization,and feeding intolerance,difference was statistically significant (all P<0.001).Conclusion Incidence of HAI in NICU is high,effective prevention and control measures should be formulated according to its risk factors,so as to reduce the occurrence of HAI in neonates.