1.Nosocomial Infection in Psychiatry Department: A Clinical Investigation and Analysis
Chinese Journal of Nosocomiology 1994;0(01):-
OBJECTIVE To explore the incidence of the nosocomial infection in patients with mental diseases,(analyze) the correlative factors and then reduce the incidence.(METHODS) By using the retrospective method,the(inpatient) cases in psychiatry department from Jan 2000 to Dec 2004 were surveyed and statistically analyzed.(RESULTS) There were 313 cases of nosocomial infection from 9 089 inpatients with mental diseases.The infection rate was(3.44%.) The total rate had been dropped year by year.The major sites of the infection were the(upper)(respiratory) tract(34.82%),the gastrointestinal tract(20.45%) and the urinary system(18.53%).The(infection) rate in ladies patient area(3.83%) was significantly higher than that of gentlemen patient area(3.07%)(P
2.Progress in research on DNA methylation and laryngeal carcinoma.
Chinese Journal of Pathology 2011;40(1):67-70
Acid Anhydride Hydrolases
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genetics
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metabolism
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Animals
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Antimetabolites, Antineoplastic
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pharmacology
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Azacitidine
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analogs & derivatives
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pharmacology
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Biomarkers, Tumor
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analysis
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Carcinoma, Squamous Cell
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diagnosis
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genetics
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metabolism
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pathology
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Cyclin-Dependent Kinase Inhibitor p16
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genetics
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metabolism
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DNA Methylation
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drug effects
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Genes, p16
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Humans
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Laryngeal Neoplasms
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diagnosis
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genetics
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metabolism
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pathology
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Neoplasm Proteins
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genetics
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metabolism
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Tumor Suppressor Proteins
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genetics
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metabolism
3.Detection of basic fibroblast growth factor receptor protein on human lens epithelial cells
International Eye Science 2008;8(8):1511-1513
· AIM: To study the expression of basic fibroblast growth factor (bFGF) receptor protein in human lens epithelial cells (HLECs). METHODS: Immunohistochemistry was used to detect the level of bFGF receptor protein and image analysis was adopted to perform the relative quantitative analysis on it. · RESULTS: There was bFGF receptor protein in HLECs accordingl to both qualitative and quantitative analysis. · CONCLUSION: bFGF receptor protein exists in HLECs and it is the material foundation for bFGF to improve the proliferation of HLECs.
4.Application of PACS system in medical imaging examination
Jing LIU ; Shiyuan LIU ; Hong YU
Chinese Journal of Medical Library and Information Science 2014;(4):73-75
After the advantages of PACS system in medical imaging examination were described, its rational appli-cation in medical imaging examination was elaborated .
5.Lead compound optimization strategy (4)--improving blood-brain barrier permeability through structural modification.
Yu HONG ; Yu ZHOU ; Jiang WANG ; Hong LIU
Acta Pharmaceutica Sinica 2014;49(6):789-799
Blood-brain barrier is a natural protection for human body. It protects central nervous system from the interruption and damage of xenobiotics. However, it prevents potential drugs aimed at central nervous system, thus becomes an obstruction for the development of central nervous system drugs. The recent development of blood-brain barrier permeability research and several lead optimization strategies to improve blood-brain barrier permeability are reviewed. These structure optimization methods include increasing lipophilicity, reducing hydrogen bond doners, simplifying molecule, increasing rigidity, lowering polar surface area, avoiding acid group, prodrug strategy, modifying into active transporter's substrates, as well as avoiding P-glycoprotein recognized structures.
ATP-Binding Cassette, Sub-Family B, Member 1
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metabolism
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Biological Transport
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Blood-Brain Barrier
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Central Nervous System
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drug effects
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Central Nervous System Agents
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pharmacokinetics
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Drug Design
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Humans
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Permeability
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Xenobiotics
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adverse effects
6.Lead compound optimization strategy (4)--improving blood-brain barrier permeability through structural modification.
Yu HONG ; Yu ZHOU ; Jiang WANG ; Hong LIU
Acta Pharmaceutica Sinica 2014;49(6):789-99
Blood-brain barrier is a natural protection for human body. It protects central nervous system from the interruption and damage of xenobiotics. However, it prevents potential drugs aimed at central nervous system, thus becomes an obstruction for the development of central nervous system drugs. The recent development of blood-brain barrier permeability research and several lead optimization strategies to improve blood-brain barrier permeability are reviewed. These structure optimization methods include increasing lipophilicity, reducing hydrogen bond doners, simplifying molecule, increasing rigidity, lowering polar surface area, avoiding acid group, prodrug strategy, modifying into active transporter's substrates, as well as avoiding P-glycoprotein recognized structures.
8.Correlation Research on the Essence of Viscera-state and Neuro-Endocrine-Immune Network-related Indicators
Yu LIU ; Hong XIANG ; Libin ZHAN
Chinese Journal of Information on Traditional Chinese Medicine 2014;(7):18-21
Objective To explore the intrinsic link between neuro-endocrine-immune (NEI) network and the viscera-state.Methods Using three databases namely TCM database, Chinese pharmacy database and combination of TCM and WM database in China Academic Journals Database, the authors searched and collected NEI-related indicators published on journals for the viscera-state researches. Then a related database was established for data mining. Through analysis of association rules, analysis of the relationship among diseases, syndromes, therapeutic principles, combination of disease and syndrome, and NEI network related indicators were performed for association rules and directional network diagrams.Results Through the association analysis, the authors drew 44 directional network diagrams of high-frequency disease positions, syndromes, therapeutic principles and NEI network related indicators, and obtained 19 association rules. Kidney and liver essence research focused on HPG axis, HPA axis, and HPT axis. Spleen essence research focused on brain-gut peptide related indicators. Heart essence research focused on vascular endothelium function indicators. Pulmonary essence research focused on humeral immunity, ET and TNF-α.Conclusion It was feasible to explore the intrinsic link between NEI network and the viscera-state by using data mining. Differences among study on NEI network of five-organs systems were found, which is of great significance for researches on the essence of the viscera-state.
9.MRA Classification of the Artery Structures at the Base of the Brain
Hong YU ; Chengyu LIU ; Yanju WANG
Journal of China Medical University 2017;46(3):261-265
Objective To observe and classify the structure of the circle of Willis by using magnetic resonance angiographic(MRA)method. Methods A total of 2104 MRA head images from October 2013 to May 2015 in Shenyang Weikang Hospital was retrospective analyzed ,and the structure was classified by anterior circle or posterior circle according to the actual situation of the cerebral basilar artery. Results According to the origin of anterior cerebral artery and whether there was anterior communicating artery or not ,anterior circle was classified into three types:type Ⅰ,type Ⅱ and type Ⅲ. Type Ⅱ was classified into two subtypes,namely,type ⅡR and type ⅡL. Posterior circle,on the basis of whether there was posterior communicating artery or not,was classified into three types,which were type Ⅰ,type Ⅱ and type Ⅲ. According to the origin of posterior cerebral artery,type Ⅰ was classified into four subtypes,including type ⅠB,type ⅠC,type ⅠRC and type ⅠLC;type Ⅱ was classified into eight subtypes,including type ⅡBR,type ⅡBL,type ⅡCR,type ⅡCL,type ⅡRCR,type ⅡRCL,type ⅡLCR and type ⅡLCL;type Ⅲ was classified into four subtypes,including type ⅢB,type ⅢC,type ⅢRC,type ⅢLC. Conclusion There is a correlation among the different types of cerebral basi-lar artery,and each type of artery has their own sources of blood supply and the traits of communication compensation. When the anterior circle and posterior circle were both type Ⅲ,the complete ring structure of cerebral basilar artery,namely the circle of Willis,was formed. The existing rate of the circle of Willis was about 10.7%. Understanding of the differences among the individual types of arteries has great significance to the prevention and treatment of the cerebrovascular disease.
10.Risk factors for healthcare-associated infection in a neonatal intensive care unit
Hong YU ; Yinmei LIU ; Huiying YANG
Chinese Journal of Infection Control 2017;16(3):233-236
Objective To understand the occurrence and risk factors of healthcare-associated infection(HAI) in a neonatal intensive care unit(NICU).Methods Neonates who were admitted to the NICU of a hospital from January 2012 to December 2014 were investigated retrospectively,risk factors for HAI were performed univariate analysis.Results A total of 760 neonates were included in the investigation,198 neonates developed 259 times of HAI,incidence of HAI was 26.05%,case incidence of HAI was 34.08%,incidence of HAI per 1 000 patient days was 9.50‰;the main infection site was lower respiratory tract (n =92,35.52%);among 259 cases of HAI,172 strains of pathogenic bacteria were isolated,the major pathogen was Acinetobacter spp.(n =40,23.26%);incidence of HAI was high in neonates with gestational age ≤32 weeks,birth weight≤1 500 g,length of hospital stay ≥10 days,duration of antimicrobial use≥10 days,mechanical ventilation,deep venous catheterization,and feeding intolerance,difference was statistically significant (all P<0.001).Conclusion Incidence of HAI in NICU is high,effective prevention and control measures should be formulated according to its risk factors,so as to reduce the occurrence of HAI in neonates.