Objective:To study the effects of FuYuan capsule on articular cartilage degradation and expression of interleukin beta 1 and transforming growth factor beta 2 in osteoarthritis(OA).Methods:Fifty-four healthy New Zealand rabbits received unilateral anterior cruciate ligament transaction(ACTL)to establish model of OA.One week after operation they were randomly divided into 4 groups,named as model control group and FuYuan capsule low,moderate and high dose groups with 12 rabbits in each group.The other 6 rabbits divided into normal control and model control group were given physiological saline.Treatment groups were perfused with FuYuan capsule(727mg/kg、1453mg/kg、4795mg/kg)once a day for 4,8 and 12 weeks.Samples of joint were collected at the 4th,8th,and 12th week after managements for general,light microscopic and electron microcope observation,and the distribution of IL-1?and TGF?2 of cartilage was documented by immunohistochemistry.Cartilage of medial femoral condyles and tibial plateau at the margin of lesion nearby were obtained and mRNA expression of TGF?2 was detected using reverse transcription-polymerase chain reaction(RT-PCR).Results:Cartilage degeneration in FuYuan capsule group was significantly slighter than that in model control group.The levels of IL-1? in treatment groups were lower significantly than those in model control group(P

Objective To determine the reliability, validity and feasibility of using International Classifica-tion of Functioning, Disability and Health (ICF) core set for breast cancer in Chinese patients. Methods Quality of life (QOL) of 110 patients with breast cancer were investigated using ICF breast cancer core set and SF-36 scale. Statistical analysis tested their reliability, validity and feasibility. Results It was shown that the ICF core set for breast cancer had good reliability, validity and feasibility. Conclusions The ICF core set for breast cancer is a re-liable and valid instrument for Chinese breast cancer patients.

The status and progression of therapy for recurrent nasopharyngeal carcinoma are expounded, including radio-therapy, surgery, chemotherapy and targeted therapy, etc. Radiotherapy is the most important mode that three-dimensional conformal radiation therapy and intensity modulation radiation therapy are strongly recommended in order to reduce the impairment of normal tissue. Surgical therapy is reasonable for the early stage patients who relapse less than a year from the initial treatment with surgical indication. Conventional radiotherapy with or without brachytherapy is recommended for those who relapse more than one year without surgical indication. Radiotherapy combining with chemotherapy, targeted therapy and sensitizer is proposed for the patients with local advanced stage by re-staging.

[Objective] To observe the effects of pine pollen on the changes of p16INK4a and p21WAF1 in 2BS cells.[Method]The 2BS cells were cultured from 28 population doubling(PD)and divided equally into the young control group,old control group,middle-dose pine pollen group(120mg/dl)and high-dose pine pollen group(240mg/dl)randomly.Regulate the phases of cell cycle by flow cytometry,and then the expression of p16INK4a,p21WAF1 mRNA were determined by semi-quantitative RT-PCR.[Result]The amount of cells in G1 phase was depressed in middle-dose pine pollen group(72.73%?1.76%)and high-dose pine pollen group(64.15%?0.87%)than in old control group(81.33%?3.43%)noticeablely(P

Filtration surgeries,especially trabeculectomy,are the most common surgeries for glaucoma.Although trabeculectomy has excellent efficacy for reducing intraocular pressure(IOP),glaucoma filtering blebs have been frequently associated with various postoperative complications including filtering bleb failure and ocular surface dysfunctions.Surgical treatments of the natural aqueous outflow system,in and around Schlemm's canal,to restore normal function without penetration of the intraocular space has been considerable interest in recent years as glaucoma surgeons continue their quest for a procedure that reduces IOP without the risk related with filtering bleb.As a result,more blebless glaucoma surgeries have developed gradually in the past years.

Bidirectional evaluation method is established for Standardized management of instructing & teaching of Radiology Technology. Four-year experience shows that it does good to the improvement of the teacher and the student.

With the development of the medical imaging and computer aided technology,the trend of the medical imag es visualization from2D to3D is focused.This paper introduces the methods and ke y technology of3D medical images visualization,and discusses its applications to medical diagnoses and clinic therapy.There is a promising direction in the fiel ds of virtual endoscope,computer assisted operation and long-distance operation.

Objective To compare the clinical efficacy of different margins in nephron-sparing operation for patients with small renal cell carcinoma. Methods From September 2008 to April 2013, a total of 64 patients with local renal cell carcinoma (T1a period) and treated with nephron-sparing operation were selected, and the clinic data were analyzed. According to cutting edge size gotten from the surgery, the patients were divided in to A group (cutting edge 1-5 mm group, 30 cases) and B group (cutting edge 6-10 mm group, 34 cases). The operation condition and recurrence rate and survival rate of two groups were compared. Results The operative time in A group was significantly shorter than that in B group:(130.1 ± 24.0) min vs. (152.3 ± 28.0) min, P<0.05. The drainage time and the level of serum creatinine in two groups had no significant differences (P>0.05). The 3-year recurrence rate and 3-year survival rate in two groups had no significant differences (P>0.05). Conclusions The clinical efficacy of different margins in nephron-sparing operation for small renal cell carcinoma is similar. But 1- 5 mm cutting edge size nephron-sparing operation has less complications, and the recurrence rate and survival rate does not increase. It is worthy of spread .

Objective To analyze cardiovascular risk factors in senile patients with acute myocardial infarction(AMI).Methods Fifty-six elderly patients with AMI aged ≥65 years were enrolled as elderly group in our hospital from January 2014 to December 2015,and 76 elderly patients with AMI aged＜65 years during the same period were selected as a non-elderly group.Cardiovascular disease-related factors were analyzed in elderly patients with AMI.Results The proportions of complicated diabetes mellitus,hypertension,and dyslipidemia were higher in 56 elderly patient[29 cases (51.8％),41 cases(73.2％)and 37 cases(66.1％)]than in 76 non-elderly patients[12 cases,(15.8 ％),23 cases(30.3％)and 17 cases(22.4％),respectively,x2 =9.652,8.744,11.489;P=0.002,0.003,0.001].The proportion of male elderly group and non-elderly group were higher than those of female patients.The prevalence of cardiovascular disease was 87.5 ％ (14/16)in female elderly patients,which was 53.2％ (17/32)in female non-elderly patients(x2 =5.510,P =0.019).The incidence of a typical chest pain,heart failure and disturbance of consciousness after AMI attack was 26.8 ％ (15/56),64.3 ％ (36/56) and 23.3 ％ (13/56) in elderly group,respectively,which were higher than those in non-elderly group[39.5 ％ (3/76),31.6 ％ (24/76),5.26 ％ (4/76);x2 =3.965,9.075,5.365;P =0.047,0.003,0.021].Conclusions Acute myocardial infarction in elderly patients often coexists with hyperlipidemia,diabetes,high blood pressure and other risk factors.There is often no significant incentive before the onset of AMI in elderly patients.Its main clinical symptoms conclude atypical chest pain,heart failure and consciousness.

Cold Temperature ; adverse effects ; Humans ; Occupational Diseases ; diagnosis ; Occupational Exposure ; adverse effects ; Skin Temperature ; Thermosensing ; physiology