[Objective]To study the regulation effects of Oridonin on pulmonary artery pressure in pulmonary hypertension rats with hypoxia-hypercapnia and its mechanism.[Methods]SD rats were divided in to three groups randomly: the normal control group(NC),the hypoxia-hpercapnia group(HH),and the hypoxia-hpercapnia plus Oridonin group(O).The time of hypoxia-hypercapnia was 4 weeks.The mean pulmonary artery pressure(mPAP),right ventricular rate(RV/(LV+S)),percentage of thickness of pulmonary artery wall in vascular external diameter(WT%),percentage of pulmonary artery wall area in total vascular area(WA%),vitality of caspase3 and caspase9,expression cyt-c of each group were observed.[Results]The mPAP,RV/(LV+S),WT%,WA% in group HH were significantly higher than those in group NC(P

Renal scarring can cause hypertension, proteinuria, chronic kidney disease, and even end stage renal disease. To understand the risk factors of renal scarring in children is helpful for its early detection, diagnosis, prevention, and treatment. High grade vesicoureteric reflux, recurrent urinary tract infection, and delayed treatment are risk factors for kidney scarring. However, there are still some controversies about the relationship between renal scarring and the some factors such as gender, age, and congenital factors. Recent studies have found that noninvasive urine indicators such as urine neutrophil gelatinase associated lipid delivery protein, urinary endothelin-1, and risk prediction models can predict the formation of renal scar. However, prophylactic use of antibiotics can reduce occurance of urinary tract infections, but do not reduce the risk of renal scarring. This article reviews the possible risk factors and predictors of renal scarring in children, providing a basis for early detection, timely intervention, and effective prevention of it in clinic, so as to reduce the formation and progression of renal scarring.

Administration, Topical ; Humans ; Immunosuppressive Agents ; administration & dosage ; adverse effects ; therapeutic use ; Lichen Planus, Oral ; complications ; drug therapy ; pathology ; Oral Ulcer ; drug therapy ; etiology ; Tacrolimus ; administration & dosage ; adverse effects ; therapeutic use ; Treatment Outcome

Adolescent ; Adult ; Aged ; Bronchoalveolar Lavage ; methods ; nursing ; Female ; Humans ; Male ; Middle Aged ; Pneumoconiosis ; nursing ; therapy ; Young Adult

Acupuncture Therapy ; Adult ; Humans ; Male ; Stiff-Person Syndrome ; therapy

Cardiomyopathies ; Heart Ventricles ; Humans

Objective To observe the short-term fusion rate of using osteophyte filled cage in ante-rior cervical disectomy and fusion. Methods From May 2007 to May 2009, 103 patients receiving anterior cervical disectomy, spine fusion by different surgeons were performed with cages containing exclusively au-tologous osteophyte collected from both anterior and posterior vertebral edges adjacent to the intervertebral space. There are 69 males, 34 females, from 25 to 77 years of age, average 53.6 years. 60 patients received one level fusion. 33 and 10 patients received two-level and three-level fusion respectively. Patients were re-viewed 3 months after operation and fusion was evaluated by X-ray film, reconstructive CT and MR. Results 1. Only 1.9% (2/103) of patients' X-ray films indicate non-fusion (internal fixation failure) while 31.7% (32/ 103) of patients' CT and 30.1% (31/103) of patients' MR indicate non-fusion or being confusing to make a diagnosis. 2. The diagnostic coherence between CT and MR as to evaluate fusion is good (kappa=0.686, P= 0.00). 3. The total fusion rate was 77.7%(80/103) while the highest fusion rate achieved by single surgeon was 90%(18/20). The total one level fusion rate was 80%(48/60) while the highest rate by single surgeon was 88.2%(15/17). The total two-level fusion rate was 78.6%(26/33) while the highest rate by single sur-geon was 90%(9/10). The total three-level fusion rate was 60%(60/100) while the highest rate by single surgeon was 100%(3/3). No statistic significant difference in fusion rate was found between any two of the three groups. Conclusion The method of using osteophyte filled cage can acquire ideal short-term fusion rate in one and two-level anterior cervical disectomy, fusion and plate fixation.

This article presents a new digital haemoglobin meter.This device adopts HICN method recommended by WHO.Its unique designing of automate proofread zero circuit and automatic controlling in determination provids high accuracy and stability,handy and reliable,It can be widely used in the hospital chemical ex- amination laboratory,commue hospital,health station and related laboratory.

Purpose: To study the influences of immune suspression by oral administration of type Ⅱ collagen on the pathogenesis of collagen induced arthritis(CIA) and traumatic oseoarthritis(OA) in rats; Methods: Rat knee traumatic osteoarthritis model made by excision of medial collateral ligament and medial meniscetomy and CIA model were applied for the observation of the changes on hisological and histochemical staining and the inhibition of T cells after oral administration of type Ⅱ collagen. Results: In OA, although the T cells were suspressed by oral administration of type Ⅱ collagen, however, the the pathogenesis was not hindered comparing with RA. It indicated that for OA, machanical factor is more important than the immunological factor, oral administration of type Ⅱ collagen has little effect on decreasing the speed of development of OA. It is not adequate to take the remedy of oral administation of type Ⅱ collagen for the treatment of OA.

Objective To investigate the distribution of nitric oxide synthase (NOS) in the spinal intermediate gray and it's relationship with hypertension. Methods Using NADPH\|d histochemistry method, the distribution of NOS in the spinal intermediate gray was investigated under microscope and analyzed quantitatively with image analysis system. Results 1 NOS positive neurons were observed mainly in the nucleus intermediolateralis thoracolumbalis pars principalis(ILp) and paracentral gray, as well as in the area of nucleus intercalatus spinalis. NOS positive cells existed in groups in ILp. The size and density of NOS positive cell groups differed with different spinal segments, no significant difference could be found in the distribution pattern of NOS positive neurons in the spinal intermediate gray between SHR and WKY. 2 The A value of NOS positive substance in the ILp of SHR was significantly lower than that in WKY. Conclusion The results imply that lower expression of NO in the area of ILp in SHR might be related to the development and maintenance of hypertension in SHR.\;