1.Effect of Oxcarbazepine on Serum Thyroid Hormones Levels of Children with Epilepsy
Journal of Applied Clinical Pediatrics 2004;0(12):-
0.05).Conclusions Long-term or short-term use of OXC can affect serum levels of thyroid hormones in children with epilepsy,so serum levels of thyroid hormones shall be monitored regularly in epileptic children treated with OXC.
2.Effect of Anti-Epileptic Drugs on Thyroid Structure and Endocrine Function in Rats
Journal of Applied Clinical Pediatrics 2006;0(17):-
0.05).Thyroid follicular volume of VPA group slightly reduced;thyroid follicular volume of OXC group increased while epithelial cells thinning;thyroid structure of LEV group had no alterations;thyroid follicular volume of OXC plus LEV group and VPA plus LEV group had no consistent alterations.Conclusions Long-term application of VPA and OXC may arouse alterations of thyroid structure and hormone secretion.LEV has no effection on thyroid function,with VPA and OXC combined usage can reduce their effection on thyroid gland.Thyroid hormone level should be monitored when using anti-epileptic drugs(ADES) long-term in clinical work.
3.The application of mechanical ventilation in whole lung lavage of pneumoconiosis.
Ji-Wei GAO ; Xin-Yu XIAO ; Xing CAO
Chinese Journal of Industrial Hygiene and Occupational Diseases 2011;29(4):274-274
Adult
;
Bronchoalveolar Lavage
;
methods
;
Female
;
Humans
;
Male
;
Middle Aged
;
Pneumoconiosis
;
therapy
;
Respiration, Artificial
;
Young Adult
4.Endoscopy nasal microsurgery and multiple techniques in treatment of nasopharyngeal angiofibromas
Tongli LI ; Dong WANG ; Yu CHEN ; Haojie ZHANG ; Caixia XING ; Yu GAO ; Xiaofeng QIAO
Cancer Research and Clinic 2008;20(5):327-328
Objective To explore the methods for endoscopy nasal microsurgery and multiple techniques in treatment of nasopharyngeal angiofibromas. Methods CT, MRI and digial substraction angiography (DSA) and endoscopic examination had been used. ALL 12 patients accepted preoperative feeding artery embolum, hypotention anesthesia and injected adrenaline-lidocaine. Microelectrotomy-electrocoagulation had been used to remove tumor. Results All patients were treated by endoscopic nasal surgery. No complications had occurred. No recurrence were found in follow-up period. Conclusion The important factors to reduce amount of introperative bleeding are to select proper operative patients and use multiple techniques. Endoscopy nasal surgery has dominance in reducing complications, wound, tumor recurrence, operative time and nasal function.
5.Sensitivity and efficacy of intraoperative electromyography monitoring in combination with 3D imaging modality during complex lumbosacral procedures
Feng XU ; Xing YU ; Lianyong BI ; Fei GAO ; Hai KE ; Lin XU
Chinese Journal of Tissue Engineering Research 2009;13(39):7613-7618
MAIN OUTCOME MEASURES: Free running EMG and stimulus triggered EMG, including time, frequency, amplitude, muscle group were observed and recorded simultaneously. Never root functional injury and restoration after surgery were detected.RESULTS: 378 pedicle screws in 74 patients were monitored intraoperatively, and only 3 pedicle screw malposition (2 of L_4, 1 of L_5) was detected and then replaced with the help of C-arm fluoroscopic examination. Myoelectricity appeared when the current intensity was less than 10 mA. The correct rate of implantation was 99.2%. Nerve root impingement was found in two cases during laminectomy for L_5 and S_1 decompression and never root solution, which alerted the surgical team of critical neural structures. Nerve symptoms of the lower limb were aggravated after surgery and restored following 2-4 weeks of conventional treatment. The error injury rate of nerve root was 2.7%. In all reported cases, no irreversible neurological deficit was observed 2-4 weeks after operation.CONCLUSION: Intraoperative EMG monitoring can find improperly placed screws and detect impending nerve root injury promptly. Combined EMG and 3-D imaging modality monitoring is a reliable and practicable method that can be used to protect neural structures during complex lumbosacral surgery.
6.Comparative pharmacokinetics of five saponins after intravenous administration of TSFS injection and TSFS injection plus TFFG in rats under different physiological states
Xiaoming LIU ; Xing ZHAO ; Enze GAO ; Yunli ZHAO ; Zheng LIU ; Zhiguo YU
Journal of Pharmaceutical Analysis 2014;(1):53-62
Sanqi is a popular traditional Chinese medicine and commonly used for promoting blood circulation and removing blood stasis. Notoginsenoside R1, ginsenoside Rg1, Re, Rb1 and Rd are the major active constituents of Sanqi. The purpose of the study was to investigate the pharmacokinetic behavior of the five active constituents from total saponin from Sanqi when it was used in the blood stasis animals or in combination with Gegen. The concentrations of the five active constituents in rat plasma were determined by an ultra-HPLC-ESI-MS/MS method. The main pharmacokinetic parameters were calculated and statistically analyzed using the unpaired student's t-test. It was found that the pharmacokinetic parameters of notoginsenoside R1, ginsenoside Rg1 and Rb1 represented a statistically significant difference (Po0.05) between the normal rats and the blood stasis rats after administration of total saponin from Sanqi (TSFS). And there were statistically significant differences (Po0.05) in the pharmacokinetic parameters of all the five constituents between administration of TSFS alone and combined with total flavonoid from Gegen (TFFG) in blood stasis rats. It suggested that the pharmacokinetic behavior of the active constituents from TSFS could be changed when it was used in blood stasis animals or in combination with TFFG.
7.Ancient clinical application of massage therapy on navel.
Xing-Yue YANG ; Yu-Xiao MA ; Si-Sheng TIAN ; Shu-Zhong GAO
Chinese Acupuncture & Moxibustion 2014;34(7):719-720
To further explore the clinical effect of massage therapy on navel,the related ancient literatures were arranged and analyzed,and several methods in ancient clinical were introduced, including stroking navel, rubbing navel, pushing navel, tapping navel and puffing navel. In addition, the theoretical basis of massage therapy on navel were discussed. The results revealed ancient literatures offered abundant theoretical basis to modern clinical practice, and there were evidences of treating gastroenteric and gynecological diseases with this therapy. Comprehensively, through the study of ancient literatures and modern research, therapy of massage on navel is believed to be promising and will gain popularity in the future.
China
;
History, Ancient
;
Humans
;
Massage
;
history
;
Medicine in Literature
;
Umbilicus
;
physiopathology
8.Expression and significance of topoisomerase Ⅱα in colorectal caner
Xianhua GAO ; Zhiqi YU ; Chang ZHANG ; Chuangang FU ; Xiaodong Xü ; Junjie XING
International Journal of Surgery 2012;39(8):522-525,封3
Objective To determine the relationship between expression of topoisomerase Ⅱ α and clinicopathological factors,overall survival in colorectal caner.Methods Expression of topoisomerase Ⅱ α was measured using EnVision immunohistochemistry in 490 colorectal cancer patients.The relationship between topoisomerase Ⅱ α expression and various clinicopathological parameters was analyzed.Kaplan-Meier analyses and multivariate analyses were used to evaluate the significance of topoisomerase Ⅱ α expression in prognosis prediction.Results Overexpression of topoisomerase Ⅱ α was found to be related with lower T stage ( P =0.042 ),lower N stage ( P =0.038 ),and possibly with lower recurrence rate ( P =0.053 ).Kaplan- Meier analyses showed that overexpression of topoisomerase Ⅱ α was related with prolonged overall survival (P =0.022 ) and prolonged disease-free survival ( P =0.036).Multivariate analyses showed that elevated serum CEA ( P < 0.001 ),elevated serum CA199 ( P =0.002 ),poor differentiation ( P =0.001 ),advanced Dukes stage ( P < 0.001 ) and lower expression of topoisomerase Ⅱ α( P =0.017 ) were independent predictive factors for poor prognosis.Conclusions Expression of topoisomerase Ⅱ α is a favorable predictive factor for colorectal cancer,and would be useful in prognosis prediction and treatment selection for early colorectal cancer and malignant colorectal polyps,especially when it is used in combinations with serum CEA,CA199 and differentiation.
9.Role of autophagy in ameliorating sepsis-induced acute lung injury by allicinin in mice
Yue PENG ; Yu JIANG ; Hao OU ; Wei XING ; Mingshi YANG ; Min GAO
Journal of Central South University(Medical Sciences) 2017;42(8):899-905
Objective:To investigate roles of autophagy in ameliorating sepsis-induced acute lung injury by allicinin in mice.Methods:A total of 152 male Balb/c mice (8-week old) were randomly divided into a sham group,a septic model group,an allicin treatment group,and an autophagy inhibition group.Septic mouse model was established by cecal ligation and puncture (CLP).Mice in the allicin treatment group were given allicin (30 mg/kg,intra-peritoneal injection) at 6 and 12 h,while those in the autophagy inhibition group were given autophagy inhibitor 3-MA (15 mg/kg,intra-peritoneal injection) at half an hour after allicin administration.Mice in the model and sham group were administered with the same amount of saline.Twenty mice in each group were randomly chosen to observe the 7 d survival rate.The other 12 mice were killed at 24 h,and the bronchoalveolar lavage fluid (BALF) (n=6) and lung tissues (n=6) were collected.ELISA was used to detect the tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in the BALF.Hematoxylin-eosin staining was preformed to show the morphological changes in the lung tissues.Malondialdehyde (MDA) content and the activity of superoxide dismutase (SOD) in the lung tissues were examined.The expression of LC3B and Beclin-1 was determined by immunohistochemical analysis.Results:Compared with the sham group,the 7 d survival rate and lung SOD activity were decreased in the CLP group (P<0.05);the lung morphological damage score,the levels of TNF-α and IL-6 in the BALF,MDA content in the lung,and expression of LC3B and Beclin-1 were increased greatly in the CLP group (P<0.05).Compared with the CLP group,the 7 d survival rate,lung SOD activity and the expressions of LC3B and Beclin-1 were increased significantly in the allicin treatment group (P<0.05);the lung morphological damage scores,the levels of TNF-α and IL-6 in the BALF and MDA content in the lung were decreased obviously in the allicin treatment group (P<0.05).Compared with the allicin treatment group,the 7 d survival rate,lung SOD activity,and the expressions of LC3B and Beclin-1 were decreased in the 3-MA group (P<0.05);the lung morphological damage scores,the levels of TNF-α and IL-6 in the BALF,and MDA content in the lung were increased significantly in the 3-MA group (P<0.05).Conclusion:Allicin may ameliorate sepsis-induced acute lung injury in mice by enhancing the level of autophagy.