1.Determination and cluster analysis of element contents in fourteen commonly used anti-tumor TCM
Weimin SUN ; Kun YU ; Dafang XUE ; Henggui XU ; Wenfeng TENG
China Journal of Traditional Chinese Medicine and Pharmacy 2005;0(02):-
0.70,cluster in two pairs of medicines are similar. Conclusion:It's reliable to cluster analysis the TCM by regarding the element contents as the character of these medicines. The larger the correlation coefficient is,the more similar the nature,flavor and efficacy of the medicines are,which suggested that trace element contents were closely related to(have much to do with) the flavor,nature and efficacy. The study provides method for the cluster relationship among TCM.
2.Study on visualization of congenital heart disease by three-dimensional echocardiographic virtual endoscopy
Haihong XUE ; Kun SUN ; Jianguo YU ; Binjin CHEN ; Weiqi WANG
Chinese Journal of Ultrasonography 2010;19(8):645-648
Objective To research the visualization of congenital heart disease by three-dimensional echocardiographic(3DE) virtual endoscopy(VE) system. Methods Datasets.from 10 healthy children and 22 patients with congenital heart disease were collected (10 patients with atrial septal defects, 6 patients with ventricular septal defects and 6 patients with tetralogy of Fallot). 3DE heart models were reconstructed by virtual reality computing techniques and visualization in scientific computing techniques. The VE system was programmed under the C++ 6.0 language condition,the visualization toolkit (VTK) platform was employed to carry out the graphics and visualization utilities. The virtual eye can move along the navigation paths in the heart by manual camera movements. Results The VE can provide special information in aspects of intracardiac anatomy, The visible heart models show precisely complex anatomy structure and spatial relationships. 3DE intracardiac endoscopic imaging can thus be visualized and navigated successfully by the VE system. Conclusions 3DE VE is a new system for the visualization of congenital heart disease.
4.Clinical value of echocardiography in diagnosing infective endocarditis in children
Yi, YU ; Kun, SUN ; Sun, CHEN ; Hai-hong, XUE ; Jian-ping, YANG
Chinese Journal of Medical Ultrasound (Electronic Edition) 2013;(8):633-638
Objective To evaluate the value of echocardiography in diagnosing infective endocarditis (IE) in children. Methods The shape, size, echogenicity, distribution of vegetations and valvular function of the heart were observed by transthoracic echocardiography (TTE) in 30 patients with suspected IE. We correlated TTE ifndings with the results of hemoculture and serologic test. Results Vegetations were observed in all patients by echocardiography:seven patients with tricuspid valve vegetations, two with mitral valve vegetations, three with pulmonary valve vegetations, three with main pulmonary artery vegetations, three with aortic valve vegetations, two with aortic valve abscess, and two with vegetations in right atrium. After anti-infection therapy, the size of vegetations in iffteen patients became smaller and the less echogenic than before. Vegetations disappeared in two patients. Vegetation was recurrent repeatedly in one case. Ten patients recovered after operation. Two severe cases died. Five patients underwent TTE again one week after the previous negative TTE. Of them, echocardiography demonstrated vegetations in three cases. However, no vegetations were found in rest two cases because antibiotics had been used at early stage. In addition, echocardiography demonstrated one patient with mitral valve vegetation. But the lesion was ifnally conifrmed to be operating suture. The sensitivity and specificity of TTE in detecting vegetations were 88.0% and 80.0%, respectively. Blood cultures were positive in twenty-seven cases and were negative in three cases. Conclusions The early diagnosis of IE is important to improve patient′s prognosis. It takes a long time in organism cultivation before achieving the clinical diagnosis. TTE can help obtain an early diagnosis stage of IE, and provide the assessment of size and location of vegetation. It plays an important role in treatment and prognosis prediction.
5.Roscovitine inhibits inflammatory hyperplasia of carotid artery intima in rats via suppressing nuclear factor-κB activation
Jingshan ZHAO ; Jiahuan SUN ; Kun YU ; Yu LIU ; Chao WANG ; Aiying LI
Chinese Journal of Pathophysiology 2017;33(2):233-238
AIM:To study the effect of roscovitine on the inflammatory hyperplasia of carotid artery intima in rats and the related mechanisms .METHODS: SD rats ( n=60 ) were randomly divided into 3 groups including control group, model group and treatment group .The rat model was established by trypsin digestion injury .The rats in control group were given sham operation .The rats in treatment group were administered with 0.5 mL roscovitine (2 g/L) slow-re-leasing gelatin.The rats in each group were fed normally for 4 weeks, then killed to take out carotid arteries for further ob-servations .The effects of roscovitine on the inflammatory hyperplasia of carotid artery intima and the related mechanism via nuclear factor-κB ( NF-κB) in the rats were detected by Western blot .RESUITS:Roscovitine inhibited the activation of NF-κB and the expression of inflammatory factors cyclooxygenase-2 (COX-2), vascular cell adhesion molecule-1 (VCAM-1),TNF-αand IL-6 via blocking the phosphorylation activation of NF-κB and inhibiting the degradation of IκB-α.CON-CLUSION:Roscovitine inhibits inflammatory hyperplasia of carotid artery intima in the rats via suppressing NF-κB activa-tion.
6.Enzooticity of the dogs, the reservoir host of Thelazia callipaeda, in Korea.
Min SEO ; Jae Ran YU ; Hyun Young PARK ; Sun HUH ; Sang Kun KIM ; Sung Tae HONG
The Korean Journal of Parasitology 2002;40(2):101-103
The reservoir hosts of Thelazia callipaeda were examined. The eyes of the 76 dogs raised at farm, 78 military dogs (shepherds), 96 cattle, and 105 pigs were investigated for the presence of eyeworm. Among them, six worms of T. callipaeda were collected from two dogs raised at farm (2.7%), and 188 worms from 26 shepherds (33.5%). No worms were recovered from the cattle or pigs. These results suggest that the dogs, especially the military dogs are serving as a reservoir host of T. callipaeda. in Korea.
Animals
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Cattle
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Disease Reservoirs/*veterinary
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Dog Diseases/epidemiology/*parasitology
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Dogs
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Eye/parasitology
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Female
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*Host-Parasite Interactions
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Korea/epidemiology
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Male
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Prevalence
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Spirurida Infections/epidemiology/parasitology/*veterinary
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Swine
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Thelazioidea/*isolation & purification
7.Current situations of medical devices in use and strategies on supervising.
Li MA ; Kun DU ; Yueshun YE ; Yi WU ; Lianjun LIN ; Yu SUN ; Liping QIN
Chinese Journal of Medical Instrumentation 2014;38(4):295-298
We are reporting in this article some analyzed data obtained from inspection and related information on current situations medical devices in use. Some ideas and suggestions are also proposed here on how to systematically and legally inspecting and monitoring medical devices in use.
Equipment Safety
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Materials Management, Hospital
8.Differential diagnosis of the peripheral lung lesions with new microvascular pattern of contrast-enhanced ultrasound
Song WANG ; Wei YANG ; Kun YAN ; Hui ZHANG ; Lan MA ; Yu SUN ; Minhua CHEN
Chinese Journal of Ultrasonography 2014;23(5):408-413
Objective To investigate the value of new microvascular pattern of contrast-enhanced ultrasonography (CEUS) in the diagnosis of peripheral lung lesion.Methods A total of 72 peripheral lung lesions which had been proved by clinical and pathology results underwent conventional ultrasound,CEUS and new microvascular pattern examination.Two independent readers (Reader 1 and Reader 2) blindly and retrospectively analysised and classified the characteristic of microvascular patterns respectively,and Kappa test was used for evaluating the concordance between the two readers.The diagnosis accuracy of CEUS was calculated,and the CEUS diagnostic scores were compared with conventional ultrasound.Results 16 benign lesions and 56 malignant lesions were enrolled in this study.The microvascular patterns in benign lesions included branch enhancement(43.8 %,31.3%),point and patchy enhancement (18.8%,25.0%) and rim-like enhancement (18.8%,18.8%).The microvascular patterns in malignant lesions included vascular enhancement (46.4%,57.1%),cotton enhancement (26.8%,25.0%) and dead wood enhancement (19.6%,8.9%).There was significant difference between benign and malignant lesions.Kappa result showed that the two readers had a good diagnosis concordance(Kappa=0.759,P =0.000).According to the different types of microvascular pattern,the diagnostic accuracy,sensitivity,and specificity rates of two readers were 92.9%,91.1%;81.3%,75.0% and 90.3%,87.5%,respectively.Before CEUS,59.7% and 68.1% of lesions were diagnosed as 3 by two readers respectively,while only 1.4% and 6.9% of lesions were diagnosed as 3 after CEUS.Further analysis demonstrated that there was significant difference in the microvascular pattern between squamous carcinoma and adenocarcinoma,and also between squamous carcinoma and small cell lung carcinoma.Conclusions Contrast-enhanced ultrasound could significantly increase the differential diagnosis of peripheral lung lesions.New microvascular pattern helped to display patterns of vascular perfusion.of peripheral lung lesions,and provide new diagnostic clue for differential diagnosis.
9.Assessment of coronary artery by prospective ECG-triggered 256 multi-slice CT on children with congenital heart diseases
Liping YAO ; Li ZHANG ; Ming DING ; Lingwei YU ; Kun SUN ; Huimin LI
Chinese Journal of Radiological Medicine and Protection 2016;36(7):534-539
Objective To investigate the image quality and radiation dosage of the prospective ECG-triggered 256 multi-slice computer tomography (MSCT) angiography in accessing coronary artery (CA) on children.Methods Coronary arteries of ninety-three children were evaluated using prospective ECG-triggered 256-MSCT with the same system setting.Seventy-four patients had the heart rate records and a four-point scoring system was applied to study the capability of MSCT in detecting CA.The signal,noise and contrast-to-noise ratio (CNR) were analyzed to investigate the association of image quality with age (n =74).Then volumetric CT dose index (CTDIvol),dose-length product (DLP) and effective dose (E) were utilized to study the association of radiation dosage with age (n =93).Results On 74 patients with heart records,the detection rate for original,proximal,middle,distal and all 11 segments of CA was 100%,97%,92%,78% and 91%,respectively.No influence of age was found on their detection (all P>0.05).E of group A,B,C and D were 1.8,1.3,0.8 and 0.7 mSv,respectively.A strong negative correlation was found between E and age (r =-0.803,P < 0.01).Higher DLP was found on elder patients,though no correlation was found between ages vs.DLP(r =0.124,P > 0.05).No correlation was found between noise vs.age (r =0.041,P > 0.05).Significantly larger signals,CNR and E(t =3.386,2.073,3.825,P < 0.05) were found on younger patients (age < 3 years).Conclusions Prospective ECG-triggered 256-MSCT has considerable performance for the evaluation of coronary arteries on children.However,children under the age of 3 are not recommended for this examinary,but for examination on children ≥ 8-year old,the tube current could be further needed.
10.Effect of Acupunctures Variable with Stages on Lumbar Intervertebral Dise Protrusion
Yu SUN ; Wenwen JIANG ; Kun WANG ; Ganggang LIU ; Ke YANG ; Haoran CHU
Chinese Journal of Rehabilitation Theory and Practice 2016;22(2):184-188
Objective To investigate the effect of acupunctures variable with stages on lumbar intervertebral dise protrusion (LIDP). Methods 98 LIDP patients in our hospital from October, 2014 to July, 2015 were randomly divided into control group (n=49) and observa-tion group (n=49) according to the sequence of first diagnosis time. The control group received routine acupuncture, and the observation group acupunctured at Ouch point and Huantiao point (GB30) with different acupuncture according to manifestations and courses. Modified Yang acupuncture was adopted in acute phase, triple acupuncture was used in remittent phase, and lateral needling was used in the recovery phase. They were both treated once a day, 7 days as a course for 3 courses with 2 days of interval. Visual Analogue Scale (VAS), Oswestry Disability Index (ODI) and clinical effects were assessed before and 1, 2, 3 courses after treatment. Results Both VAS and ODI scores im-proved after treatment (F>7.12, P<0.05), especially in the observation group (t>4.43, P<0.05). The efficiency was higher in the observation group than in the control group (χ2=5.594, P<0.05). Conclusion Compared with normal acupuncture, the acupunctures variable with stages is more effective on LIDP than routine.