1.Preliminary study on the antioxidant and anti-fatigue effect of recombinant SOD.
Shu-Tao LIU ; Hang CHEN ; Yu-Ting CAI
Chinese Journal of Applied Physiology 2009;25(1):137-138
Animals
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Antioxidants
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pharmacology
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Fatigue
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prevention & control
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Male
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Mice
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Physical Exertion
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physiology
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Random Allocation
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Recombinant Proteins
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genetics
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metabolism
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pharmacology
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Superoxide Dismutase
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genetics
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metabolism
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pharmacology
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Swimming
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physiology
2.The integral term of the information entropy unadapted for being a measuring index
Hang YU ; Yang HONG ; Zhi QU ; Li LIU
Chinese Journal of Medical Physics 2001;18(1):57-59
The information entropy, H = - Pk log Pk, has been proved in this paper to be always positive and invariant for a linear coordinate transformation, so that it can be used as a measuring index. On the contrary, the integral term of the information entropy, H(x) = -f(x) log f(x) dx, is not always positive and invariant for a linear coordinate transformation. Therefore, H(x) can not be used as a measuring index. An example of a probability density function for response of nerve to electric current with different intensities is given to confirm above conclusions.
3.Olfactory function in patients with Alzheimer' disease.
Huanxin YU ; Wei HANG ; Jinling ZHANG ; Gang LIU
Journal of Clinical Otorhinolaryngology Head and Neck Surgery 2015;29(5):444-447
OBJECTIVE:
To analyze the relationship between olfactory bulb (OB) volume, depth of olfactory sulcus (OS) and olfactory function in patients with Alzheimer' disease (AD).
METHOD:
Fifty patients with AD patients and 50 healthy subjects were examined by olfactory function T&T testing, OB volume and depth of OS assessed with Magnetic resonance imaging (MRI).
RESULT:
T&T olfactory testing revealed that AD patients had higher scores than control group (1.50 ± 0.17, 2.80 ± 0.31, P < 0.05). Bilateral and average OB volumes were smaller in AD group [(29.78 ± 5.17) mm3, (30.14 ± 4.87)mm3, (30.05 ± 5.08) mm3] than in control group [(36.65 ± 4.08)mm3, (36.56 ± 4.12)mm3, (36.46 ± 4.11)mm3] (P < 0.01). OS depth study revealed no statistical difference between AD patients and control groups (P > 0.05). Olfactory discriminate threshold was negatively correlated with average olfactory bulb volumes (r = -0. 711, P < 0.05), and was not correlated with depth of OS (r = -0.127, P > 0.05) in AD patients.
CONCLUSION
The OB volume were lower in AD patients as compare to controls, the depth of OS has no significant changes in AD patients; The OB volume is correlated with olfactory function, the depth of OS is no correlated with olfactory function. Cognitive impairment degree in AD patients is accordance with the lower degree olfactory function. The olfactory loss may be the earlier period and objective diagnosis indicator for AD patients.
Alzheimer Disease
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complications
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physiopathology
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Case-Control Studies
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Humans
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Magnetic Resonance Imaging
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Olfaction Disorders
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complications
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diagnosis
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Olfactory Bulb
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anatomy & histology
4.Application of EWGSOP Consensus in Evaluating Elderly Female Patients with Sarcopenia Ranging in age from 70 to 79 from Communities of Shanghai
Haipeng LI ; Yu LIU ; Lingyan HUANG ; Keyi YIN ; Hang QU
Chinese Journal of Sports Medicine 2017;36(6):506-512
Objective To explore the feasibility of using the consensus of European Working Group on Sarcopenia in Older People(EWGSOP) to diagnose sarcopenia among community-dwelling women aged from seventy to seventy-nine in Shanghai.Methods Twenty-two healthy community-dwelling women were recruited as the subject group(group S),and another ten young girls were randomly selected as the control group(group C).The anthropometry,bioelectrical impedance analysis(BIA)and dual energy X-ray absorptionmetry(DEXA)were used to evaluate the circumferences of upper and lower limbs,and the dimension of muscle mass,according to relative appendicular skeletal mass(RASM)and skeletal muscle index(SMI).The grip dynamometer and isokinetic dynamometer were used to measure the muscle strength of upper and lower limbs.The ten meters gait speed,functional reach test,timed up and go test,Berg balance scale and short physical performance battery were all applied to assess the physical performance.The criteria of EWGSOP consensus were applied to diagnose the situation of sarcopenia.Results Firstly,the average biceps circumference and fat mass of upper limbs in group S were significantly higher than group C (P<0.01),while no significant differences were observed in the muscle mass(P>0.05).Secondly,RASM values gained from BIA and DEXA in S group were significantly higher than C group(P<0.05),while the SMI values of the former were significantly lower than the latter(P< 0.01).Thirdly,absolute grip strength,relative grip strength and other bio-mechanical indexes of lower limbs in the s group were significantly lower than the C group(P<0.01);the relative grip strength showed significant correlation with most bio-mechanical indexes of lower limbs.Fourthly,the physical performance in group S declined significantly compared with that of the c group(P<O.05),and no significant correlation was found between muscle strength and physical performance of upper limbs except the absolute grip strength and gait speed.The prevalence was 0% according to the RASM index,while the prevalence was 63.6% and 45.4% according to the BIA and DEXA respectively.Conclusion The assessing pattern from EWGSOP consensus could not be simply copied to applying on Chinese old people due to serious difference between RASM and SMI.The combination of SMI+relative grip strength+ TUG/SPPB/Berg may be better than the classical mode of RASM+absolute grip strength+gait speed in diagnosing sarcopenia.
5.The study of change of heart function and myocardial histopathology after retrograde coronary venous bypass grafting
Zong-Hong LIU ; Hong-Yu LIU ; Guo-Zhen YU ; Hang LV ; Chao CHI ; Chunyu LI ;
Chinese Journal of Thoracic and Cardiovascular Surgery 1995;0(05):-
Objective To study the effect of heart function and histopathology after coronary vein bypass grafting.Methods 16 pigs were divided into experimental group and control group.Following 16 pig models of chronic myocardial isehemia of left ventri- cle were established,the left internal mammary artery (LIMA)-great cardiac vein (GCV) anastomasis in 8 pigs were completed 4 week later.After GCV occlusion at proximal,retrograde coronary venous perfusion was afforded.At 8 week,coronary angiography,echo- cardiography and myocardial radioisotope scanning were performed.After harvesting these hearts,histopathologic examination and electron microscope were undertaken.Results All anastomotic vessels of experimental pigs were smooth.LVEF in experimental group was significant higher than that in control group (P
6.Research Progress in Chemical Constituents of Qi-Gui-Yin Compound
Xiaojie YU ; Jiayu ZHANG ; Qingquan LIU ; Yonggang LIU ; Xin FENG ; Hang SHI ; Qun MA
World Science and Technology-Modernization of Traditional Chinese Medicine 2014;(5):1071-1078
Qi-Gui-Yin (QGY) compound, which composes of five herbal medicines of Astragalus membranaceus (Fisch.) Bge., Angelica sinensis (Oliv.) Diels, Lonicera japonica Thunb., Artemisia annua L., and Polygonum cuspidatum Sieb.et Zucc., which is able to treat antibiotic-resistant bacteria with antibiotics, and also to delay or even reverse the bacterial resistance producing. However, QGY compound is a complex mixture. And it is very difficult to elaborate its material foundation. Therefore, chemical constituents in five herbal medicines were summarized through searching of the related literatures. And then, 170 kinds of bioactive ingredients were classi-fied in order to provide evidences for the study on chemical constituent of QGY compound and identify its mate-rial foundation of delaying drug resistance .
7.Design, synthesis and antiproliferative activities of artemisinin derivatives substituted by N-heterocycles.
Zhizhong ZUO ; Hang ZHONG ; Ting CAI ; Yu BAO ; Zhiqiang LIU ; Dan LIU ; Linxiang ZHAO
Acta Pharmaceutica Sinica 2015;50(7):868-74
Increasing attention has been focused on the antitumor activity of artemisinin derivatives in recent years, for artemisinin had been reported to have cytotoxic effects against HL-60, P388 and MCF-7 tumor cells. We report here the synthesis and evaluation for antitumor activity of a series of artemisinin-ether derivatives bearing tetrahydropyrrole, morpholine, piperidine, substituted piperidines and azoles with various linkers. Sixteen 10-O-substituted dihydroartemisinin derivatives were designed and synthesized, all of which have never been reported in literatures and whose antiproliferative effects on human breast cancer MCF-7, MCF-7/Adr and HL-60 cells were determined by MTT assay or direct cell counting. Each of these artemisinin derivatives possessed better effects than dihydroartemisinin evidently against HL-60 and MCF-7 cells growth, while less potent than doxorubicin. All target compounds exhibited significantly improved potency compared to DHA and doxorubicin on the doxorubicin-resistant MCF-7/Adr cells, so did they in their sensitive counterparts MCF-7 cells. Among them, compounds GF02, GH04 and ZH04 showed strong activity against these three cell lines growth. Further research is undergoing.
8.Diagnostic value of single balloon enteroscopy for obscure gastrointestinal bleeding
Yunhong LI ; Ying LU ; Xiaoqi HANG ; Mingdong LIU ; Yuling YAO ; Chenggong YU ; Yulin WU ; Xiaoping ZOU
Chinese Journal of Digestive Endoscopy 2012;29(9):510-512
ObjectiveTo investigate the diagnostic value of single balloon enteroscopy (SBE) for obscure gastrointestinal bleeding.MethodsA total of 78 SBE procedures was conducted on 72 patients with obscure gastrointestinal bleeding,with 40 via oral route and 38 via anal route.The procedure time,insertion depth and rate of positive finding were recorded.ResultsFor 40 SBE procedures performed via oral route,the mean procedure time was 60 minutes ( 15-110 minutes),and the mean insertion depth was 195 cm at the distal end of Trentz ligament (30-240 cm).For 38 SBE procedures performed via anus,the mean procedure time was 75 minuets (30-120 minutes),and the mean insertion depth was 160 cm at the proximal end of ileocecal valve (50-200 cm ).The whole diagnostic yield of obscure gastrointestinal bleeding was 62.5%.ConclusionSBE is a safe and useful tool for the diagnosis of obscure gastrointestinal bleeding.
9.Research on expression and function of phosphorylated DARPP-32 on pentylenetetrazol-induced epilepsy model of rat.
Weiwen WANG ; Xiaoyang LIAO ; Zhenghui YANG ; Hang LIN ; Qingsong WANG ; Yuxian WU ; Yu LIU
Journal of Biomedical Engineering 2014;31(3):637-641
The present study is to explore the change process and distribution of phosphorylated DARPP-32 (p-DARPP-32) in rat brain including cortex, hippocampus and striatum and to further deduce whether p-DARPP-32 was possibly involved in epilepsy induced by repetitive low doses of pentylenetetrazol (PTZ). PTZ-induced epilepsy model in rat was established with 30 male SD rats randomly divided into 6 groups, control group and five trial groups [PTZ 1 h, PTZ 6 h, PTZ 24 h, PTZ 48 h and PTZ 72 h respectively, after onset of status epilepticus (SE)]. Immunohistochemistry and immunofluorescence double-labeling were used to detect the temporal time change and distribution of p-DARPP-32 expression and to analyze the coexpression of DARPP-32 and p-DARPP-32 in rat brain after the onset of PTZ-induced generalized SE. The results showed that there was a temporal time change of p-DARPP-32 expression in rat brain after the onset of SE. The number of p-DARPP-32-positive cells increased significantly and reached the peaks at the ends of 1 hour and 6 hours after the onset of SE, but decreased at the end of 24 hours. The moderate to strong p-DARPP-32-immunopositive neurons were observed in cortex, hippocampus and striatum, and located in cell cytoplasm and cell nucleus. Further immunofluorescence double-labeling revealed that denser colocalization of p-DARPP-32 and DARPP-32 in the neurons existed in the area mentioned above. Therefore, PTZ-induced SE may cause phosphorylation of DARPP-32 in rat brain. The temporal time change and distribution of p-DARPP-32 suggest that phosphorylation of DARPP-32 may be involved in PTZ-induced epilepsy in rat brain including cortex, hippocampus and striatum, and p-DARPP-32 may play a central role in the onset of SE.
Animals
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Cerebral Cortex
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metabolism
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Corpus Striatum
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metabolism
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Dopamine and cAMP-Regulated Phosphoprotein 32
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metabolism
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Hippocampus
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metabolism
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Male
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Neurons
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metabolism
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Pentylenetetrazole
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Rats
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Rats, Sprague-Dawley
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Status Epilepticus
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chemically induced
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metabolism
10.Fever of unknown origin in a long-term bed-ridden patient.
Fang FANG ; Yi-chun YU ; Qi-hang CHEN ; Dong-ge LIU
Chinese Journal of Pathology 2012;41(8):564-566
Aged, 80 and over
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Aspergillus
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isolation & purification
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Fever of Unknown Origin
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etiology
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Humans
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Invasive Pulmonary Aspergillosis
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complications
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microbiology
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pathology
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Length of Stay
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Long-Term Care
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Lung Diseases, Interstitial
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complications
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pathology
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Male
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Pulmonary Alveoli
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pathology
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Respiratory Distress Syndrome, Adult
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complications
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pathology