1.Age-related tabular involution and breast cancer
Fei WANG ; Zhigang YU ; Zhongbing MA
International Journal of Surgery 2010;37(7):493-496
With the age increasing,the lobules in women's breasts undergo progressive involution or regression,which is called age-related lobular involution.It's a physiologic and irreversible process,while the rate and extent of involution vary considerably among individual women.It has been hypothesized that the extent of age-related lobular involution is strongly associated with a reduced risk of breast cancer,and there are some associations between lobular involution and risk factors of breast cancer.
3.Intravenous immunoglobulin in adjuvantly treatment of severe pneumonia of infant
Qingshan MA ; Jirong LU ; Yunfeng ZHANG ; Fei YU
Chinese Journal of New Drugs and Clinical Remedies 2001;20(2):123-124
AIM: To study the clinical efficacy and safety of intravenous immunoglobulin (IVIG) for infant with severe pneumonia. METHODS: Seventy patients of infant with severe pneumonia were divided into 2 groups. Patinets (n=50) of the trea- tment group (M 30, F 20; age 6 mo± s 5 mo) were treated with IVIG and conventional drugs, IVIG 400 mg*kg-1*d-1 for 3 d. Patinets (n=20) of the control group (M 12, F 8; age 7 mo±7 mo) were treated with conventional drugs. RESULTS: The duration of fever, tachypnea, high heart rate shortened. The gasp and rales disappeared earlier. The cardiac failure recovered faster than the control group. There was significantly diffference statistically (P<0.05). The level of IgG, IgA raised after treatment. There was significantly difference statistically (P<0.01). The level of CD+3, CD+4, CD+8 after treatment also raised significantly compared with that before treatment (P<0.05). IL-6 and IL-8 after treatment reduced. There was significantly difference statistically (P<0.05). CONCLUSION: IVIG is safe and effective drug in adjuvant treating severe pneumonia of infant, specially RSV pneumonia.
4.Study of the A/G49 polymorphism of CTLA-4 gene exon 1 in autoimmune thyroid diseases
Luan WANG ; Fei WANG ; Ruixin MA ; Hongwei YU
Immunological Journal 2001;(2):116-118
Objective To investigate the association of gene polymorphism of cytotoxic T lymphocyte-associated antigen 4(CTLA-4) with autoimmune thyroid diseases. Methods The A/G transition polymorphism at position 49(exon 1,codon 17) of the CTLA-4 gene was determined by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP)method in 122 autoimmune thyroid diseases patients which included 87 Graves’ disease (GD) patients and 35 Hashimoto's thyroiditis(HT) patients, as well as 84 control subjects. We detected their thyroid function by ELISA technique, and the thyroid autoimmune antibodies (TGAb,TPOAb) by indirect immunofluorescent technique. Results The strong association of the CTLA-4/G49 allele with AITDs was seen in our study(66.4% vs 36.9% P<0.0001). The G allele in GD patients was significantly increased compared with control subjects(69.5% vs 36.9%, P<0.0001). In HT patients, the frequency of G allele was also higher than control subjects(58.6% vs 36.9%,P<0.01), and there was no significant difference between HT and GD groups. When GD and HT subjects were stratified with respect to sex, neither female nor male patients demonstrated evident association of G49 allele with gender.Conclusions The polymorphism of CTLA-4 gene (exon 1 condon 17 position 49)confers susceptibility to AITDs. This association is independent of sex.
5.ANALYSIS ON MYCOFLORA IN BOTTLED PURIFIED DRINKING WATER
Qun-Fei MA ; Yu-Huan YANG ; Wei-Wei CHEN ;
Microbiology 1992;0(04):-
The study on mycoflora in bottled purified d rinking water was carried out.91 Samples of products were colleted from 59 bottl ing factories in Fujian Province and were examined and identified.461 Strains of fungi were isolated from 58(63 74%)different samples.Fungi imperfecti was the e umycetes isolated most frequently.These fungi were not closely related to the ae robic bacterial count and coliform of the studied waters but was clearly associa ted with the packaging of the products.The result confirmed that the cross conta minations on the process of post-purification were the main source of fungi in the final products.
6.Advance in studies on Aconitum traditional Chinese medicines in toxicokinetics and metabonomics.
Tian-Yu MA ; Teng-Fei YU ; Shu-Min LI ; Gang LI
China Journal of Chinese Materia Medica 2014;39(11):1972-1975
Aconitum, as a kind of common traditional Chinese medicine, contains multiple biological active substances, with a very high medicinal value but high toxicity. Its major toxic ingredients are aconitine, mesaconitine and hypaconitine, which are also efficient ingredients. Therefore, the safety of its clinical application has aroused wide attention. With the constant deepening of drug development studies, people want to learn about its toxic mechanism and the regularity of its emergence and development of its toxicology, so as to make a scientific and rational assessment for its safety. Therefore, toxicokinetics and metabonomics have gradually become important content in the new drug assessment. During the development of drug performance, it is crucial to establish a scientific, objective and standardized Aconitum safety evaluation system and correctly assess and utilize its toxicity. Having summarized studies on metabonomics and toxicokinetics of Aconitum drugs in recent years, authors proposed to strengthen the studies on Aconitum drug safety assessment and establish a scientific and standardized safety evaluation system as soon as possible, in order to make the national treasure more useful.
Aconitum
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chemistry
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toxicity
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Animals
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Drugs, Chinese Herbal
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pharmacokinetics
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toxicity
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Humans
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Metabolomics
7.Primary testicular yolk sac tumor: clinicopathological study of 8 cases.
Fei-Fei LIU ; Jian-Jun WANG ; Qin SHEN ; Bo YU ; Zhen-Feng LU ; Heng-Hui MA ; Qun-Li SHI
National Journal of Andrology 2014;20(5):435-438
OBJECTIVETo investigate the clinicopathological characteristics, diagnosis and treatment of primary testicular yolk sac tumor (YST).
METHODSWe studied 8 cases of primary testicular YST by microscopy and immunohistochemistry.
RESULTSThe 8 cases of primary testicular YST, including 2 consultation cases, were confirmed from 1998 to 2013, accounting for 10.7% (8/75) of all the testicular germ cell tumors diagnosed in our hospital. The patients ranged in age from 7 to 43 years, 23.9 years on average. The main clinical manifestation of the patients was painless unilateral testis swelling. Microscopically, reticular tissues, schiller-duvaI (S-D) bodies, and eosin-stain transparent bodies were seen in the tumors. One of the cases was confirmed to be simple YST, while the other 7 mixed YST. AFP was a characteristic immunophenotype marker of the tumors.
CONCLUSIONPrimary testicular YST is a rare malignancyr with poor prognosis. Its diagnosis depends on preoperative AFP test and postoperative pathology. Comprehensive treatment, including orchiectomy, chemotherapy, and radiotherapy, can prolong the survival of the patients.
Adolescent ; Adult ; Child ; Endodermal Sinus Tumor ; metabolism ; pathology ; therapy ; Humans ; Immunohistochemistry ; Male ; Neoplasms, Germ Cell and Embryonal ; metabolism ; pathology ; therapy ; Orchiectomy ; Rare Diseases ; metabolism ; pathology ; therapy ; Testicular Neoplasms ; metabolism ; pathology ; therapy ; Young Adult
8.Clinical analysis of 31 patients with fungemia
Xiao-Bo MA ; Xiao-Ju LII ; Fei-Fei NIU ; Xiao-Jing GUO ; Xiaofu PAN ; Yan-Yu GAO ;
Chinese Journal of Infection and Chemotherapy 2007;0(01):-
Objective To investigate the epiderniology of fungemia and provide evidence for clinical therapy.Methods A retro- spective survey was done with the 31 cases of fungemia in our hospital from August 2004 to November 2005.Results More than 80% of the patients suffered from two and more underlying diseases.Over a half of infections developed following placement of catheters.And 83.9% of the patients had a history of antimicrobial agents use before blood culture.The pathogens of 24 (77.4%) cases were associated with Candida spp.Only 3 strains were C.albicans.The mortality rate of candidemia was 45.8%.Different Candida species had different resistance rates to antifungal agents.Conclusions Fungemia patients often have serious underlying diseases.Most fungemia cases were candidemia caused by non-C.albicans.Some fungal pathogens are re- sistant to fluconazole and itraconazole.
10.The different suppression on voltage-dependent potassium channels currents of smooth muscle cells from cerebral pial arteries and penetrating arteries by subarachnoid hemorrhage
Fei WANG ; Huanzhi WANG ; Shipeng LI ; Tao SUN ; Yiliu MA ; Hualin YU
Chinese Journal of Neurology 2014;47(12):871-875
Objective To study the effect of subarachnoid hemorrhage (SAH) on voltagedependent potassium channels (Kv) currents of smooth muscle cells,which is hypothesized to be different between cerebral pial arteries and penetrating arteries.Methods Smooth muscle cells from cerebral pial arteries and penetrating arteries in rats were enzymatically isolated 72 h after SAH,and patch clamp was used to test the relative cell size,resting potential and Kv currents.Results Resting potential of either pial ((45.63 ±1.18) mV) or penetrating artery ((41.55-± 1.19) mV) was shifted positively by SAH,even more significantly in latter (F =8.24,P < 0.05 ; F =9.36,P < 0.01) ; Resting potential of pial artery of control ((38.76 ± 1.03) mV),penetrating artery of control ((38.53 ± 0.67) mV),pial artery of SAH ((36.87 ± 1.49) mV) and penetrating artery of SAH((37.89 ± 1.24) mV) were shifted positively to the same level by 1 μmol/L 4-aminopyridine (4AP; F =3.08,P >0.05).Maximum Current Density (Imax) of either pial ((20.82 ±0.59) pA/pF) or penetrating artery ((15.15 ±0.37) pA/pF) was compromised by SAH,also more significantly in latter (F =6.22,P < 0.05) ; Imax of pial artery of control (9.15 ± 0.16),penetrating artery of control (9.04 ± 0.36),pial artery of SAH (8.77 ± 0.26) and penetrating artery of SAH (9.12 ± 0.17) were decreased to the same level by 1 μmol/L 4AP (F =2.96,P > 0.05).Conclusions SAH probably shares the similar pathway with Kv blocker (4AP) in Kv currents inhibition.Further,SAH differently inhibits smooth muscle cells Kv currents and resting potential of cerebral pial arteries and penetrating arteries,which may be related with their different sensitivity towards cerebral vasospasm following SAH.