1.SALL4 and hematologic neoplasms
Journal of International Oncology 2011;38(1):64-66
SALL4 gene is closely related to body malformations related diseases, embryonic stem cell development, and hematopoietic malignancies. SALL4 can activate hematopoietic stem cell through Wnt signaling pathways, and promote continued proliferation of leukemia stem cells, leading to leukemia. In-depth study of SALL4 gene and its protein function will help clarify the pathogenesis of leukemia, providing a new target for the treatment of leukemia.
2.A more sensitive method for the evaluation of visceral pain sensitivity in rat.
Yu CHEN ; Chun LIN ; Ai-Qin CHEN
Chinese Journal of Applied Physiology 2009;25(1):54-59
Abdominal Muscles
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physiology
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Abdominal Pain
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diagnosis
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physiopathology
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Animals
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Animals, Newborn
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Colon
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innervation
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Electrodes
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Electromyography
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Female
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Pain Measurement
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methods
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Pain Threshold
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physiology
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Rats
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Rats, Sprague-Dawley
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Viscera
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Visceral Afferents
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physiology
3.An Investigation Analysis of Medical Ethics Education for Medical Students,Interns and Clinical Doctors
Lin LIN ; Nini YU ; Qiongqiu CHEN ; Xie CHEN
Chinese Medical Ethics 1994;0(06):-
Currently,medical ethics education is well popularized,yet not popular among medical students,interns or clinical doctors,for which its formalistic teaching content and mode are to blame.To realize its real educative effects,infiltrating medical ethics into the ideological perception among medical students,interns and clinical doctors,besides horizontal expansion in education popularity,more emphasis should be put to grasping and instructing the essence of medical ethics on a vertical level in order to make the recognition of medical ethics education as common sense among medical professionals.
5.Clinical Observation of Paclitaxel or 5-Fluorouracil Combined with Nadaplatin in the Treatment of Ad-vanced Nasopharyngeal Carcinoma
Guangsheng YANG ; Lin CHEN ; Yu LI
China Pharmacy 2016;27(17):2397-2399
OBJECTIVE:To observe clinical efficacy and safety of paclitaxel or 5-fluorouracil combined with nadaplatin in the treatment of advanced nasopharyngeal carcinoma(NPC). METHODS:42 patients with advanced NPC were randomly divided into observation group and control group(n=21). 2 groups of patients were treated with radiotherapy. Observation group received che-motherapy of paclitaxel(135 mg/m2,d1)and nedaplatin(80 mg/m2,d 2-4);control group received chemotherapy of 5-fluoroura-cil(500 mg/m2,d1-5)and nedaplatin(80 mg/m2,d1-3);a treatment course lasted for 3 weeks,and both groups received 2 courses of treatment. Clinical efficacy, survival rate and ADR were observed in 2 groups. RESULTS:The overall response rate was 95.2%in observation group and 90.5% in control group,with no significant difference between 2 groups (P>0.05). The 3-year overall survival rate and progression-free survival rate were 81.0% and 71.4% in observation group and 76.2% and 66.6% in control group,with no significant difference(P>0.05). The incidence of nausea and vomiting in observation group were lower than in con-trol group,while the incidence of oral mucosa inflammation was higher than control group,with statistical significance(P<0.05). CONCLUSIONS:The chemoradiotherapy of paclitaxel or 5-fluorouracil combined with nadaplatin have similar therapeutic efficacy for advanced NPC. ADR by chemoradiotherapy should be monitored closely and treated timely.
6.The procedure for the prolapse and haemorrhoids in the management of severe haemorrhoids
Junyong CHEN ; Ronglun YU ; Yuangang LIN
Chinese Journal of Primary Medicine and Pharmacy 2006;0(07):-
Objective The aim of this study was to demonstrate the effectiveness of the procedure for the prolapse and haemorrhoids in management of haemorrhodis.Methods Analyze the data of sixty-two consecutive patients with third or fourth degree hameorrhoids treated by the procedure for the prolapse and haemorrhoids.Results The median surgical time was 15 minutes,the median postoperative hospital stay was 2.3 days,median time to retum to normal activity was 6.8 days.Five patients need postoperative analgesic,on postoperative bleeding,eighteen patients had acute urinary retention.Fifty-six(90.32%) of the patinets had been followed up to 6 weeks,fifty patients were satisfied with the results of the procedure.Conclusion The procedure for the prolapse and haemorrhoids is a safe and effective treatment for severe haemorrhoids and with the advantages of shorter time of operation and inpatient stay,earlier return to normal activity.
7.Observation on the curative effect of simvastatin treat carotid atheroma.
Hangjun CHEN ; Yi YU ; Xuexiang LIN
Chinese Journal of Practical Internal Medicine 2001;0(07):-
Objective To observe the curative effect of simvastatin to treat carotid atheroma. Methods 106 patients with carotid atheroma were randomly divided into two groups. The treatment group( n=56) was given orally 20 micro-gram of simvastatin every night, while the matched control group( n = 50) was given 100 microgram of aspirin enteric-coated everyday for 4 months. Results After four months of follow-up, the carotid artery inner-intermediate thickness and the speckle's size,examined by the color Doppler, were obviously decreased ( P 0.05). Conclusion Simvastatin can obviously ameliorate the carotid atheroma. It can be served as one of the normal selections for treating the carotid atheroma.
8. Protective effects of Salvia miltiorrhiza and Carthamus tinctorius active ingredients in different compatibility on cerebral ischemia/reperfusion injury in rats
Chinese Traditional and Herbal Drugs 2018;49(16):3875-3881
Objective To explore the protective effects of Salvia miltiorrhiza and Carthamus tinctorius active ingredients in different compatibility on cerebral ischemia-reperfusion injury in rats. Methods Adult male Sprague-Dawley (SD) rats were selected to establish a cerebral ischemia-reperfusion (I/R) injury model by middle cerebral artery occlusion (MCAO) method. The rats were randomly divided into sham operation group, model group, and positive control group (Danhong Injection 2 mL/kg); And orthogonal test method L9(34) was adopted to compose nine compatibility groups from main active ingredients of S. miltiorrhiza and C. tinctorius (trashinol, salvianolic acid A, salvianolic acid B, and HYSA). Rats were tail iv administrated once daily for continuous 3 d. Score neurological deficit was evaluated after 3 d; qRT-PCR was used to detect mRNA expression of glucose regulated protein 78 (GRP-78), nuclear factor-κB (NF-κB), C/EBP homologous protein (CHOP), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6); HE staining was used to detect the pathological changes of cerebral cortex, and the expression of NF-κB p65 protein in cerebral cortex was detected by immunohistochemistry. Results Compared to the model group, Danhong Injection group and orthogonal compatibility nine groups significantly reduced the neurological deficit scores of rats with cerebral ischemia-reperfusion; increased the mRNA expression of GRP-78 in the cerebral cortex; decrease the mRNA expression of NF-κB, CHOP, TNF-α, and IL-6, and decrease the protein expression of NF-κB p65 in the cerebral cortex. The results also showed that the protective effects of the 4th group (danshensu 30 mg/kg, salvianolic acid A 2.5 mg/kg, salvianolic acid B 16 mg/kg, and HYSA 8 mg/kg), 6th group (trashinol 30 mg/kg, salvianolic acid A 10 mg/kg, salvianolic acid B 8 mg/kg, and HYSA 4 mg/kg) in the 9th group were more significant for cerebral ischemia reperfusion injury in rats. Conclusion The active components of S. miltiorrhiza and C. tinctorius can play a good protective role in endoplasmic reticulum stress and inflammation in rats with cerebral ischemia reperfusion injury.
9.Combined traditional Chinese and western medicine treatment of early postoperation inflammatory small bowel obstruction
Lin LIAO ; Hong CHEN ; Yuan-Long YU ;
Chinese Journal of Primary Medicine and Pharmacy 2006;0(08):-
Objective To investigate the principles of combined traditional Chinese and western medicine treatment of early postoperation inflammatory small bowel obstruction(EPISBO).Methods 93 cases of EPISBO were randomly divided into two groups including group A,47 cases received combined traditional Chinese and west- ern medicine treatment,and group B 46 received only western medicine treatment.Results 93 patients were all cured through nonsurgical treatment.The combined traditional Chinese and western medicine treatment was better in symtom improvement and reduce of expense.Conclusion The principle treatment of EPISBO is mainly nonsurgical. The traditional Chinese medicine and somatostatin are very important.
10.Retrospective Study on Clinical and Imaging Features of Foot-Yangming Meridian-muscle Syndrome of Knee Osteoarthritis
Journal of Guangzhou University of Traditional Chinese Medicine 2016;33(5):658-661
Objective To investigate the clinical and imaging features of Foot-Yangming meridian-muscle syndrome of knee osteoarthritis(KOA) so as to promote the normalization and standardization of the meridian-muscle therapies. Methods A total of 31 KOA cases (involving 31 knees) of Foot-Yangming meridian-muscle syndrome were included into the study group , and 31 healthy volunteers (involving 31 knees) served as the control group. A retrospective research of patellofemoral relationship was carried out based on the clinical and imaging features. Results The differences of Insall index and patella index between the study group and control group were insignificant(P> 0 . 05), but the differences of patellofemoral index , patellofemoral congruence angle, and external patellar angle between the study group and control group were significant(P<0.01). Conclusion The patellofemoral relationship disorder is one of main lesions in Foot-Yangming meridian-muscle syndrome of KOA.