We meniscectomized 27 knees with meniscal lesions for disabling symptoms after the diagnosis by clinical evaluation and arthrography from January, 1970 to May,1979. Statistical analyses were as follows: 1. Male was affected 2 times more than female. The most meniscal lesions occurred in the age group between 10 and 29 years old (67%). 2. The lateral menisci were affected 2 times than the medial. In the former, the middle segments were affected most frequently and in the latter, the posterior horns. 3. The general diagnosis of torn meniscus for the 27 knees was correct by clinical evaluation for 19(71%), by arthrography for 20 (74%) and by two methods for 24 (88%). 4. In the follow-up study, satisfactory results were obtained in. 79%.
Animals ; Arthrography ; Clinical Study ; Diagnosis ; Female ; Follow-Up Studies ; Horns ; Humans ; Knee ; Male ; Menisci, Tibial

OBJECTIVE: The aim of the study was to evaluate the corelation between an expression of lectins and survival of patients with squamous cell carcinoma of uterine cervix. METHODS: The cell surface carbohydrate profile of formalin-fixed paraffin embedded tissue section of squamous cell carcinoma of the uterine cervix was evaluated using ulex europaeus agglutinin(UEA-1), peanut agglutinin(PNA), dolichos biflorus agglutinin(DBA), soybean agglutinin(SBA) and lotus tetragonobus lectin(LTL) by the avidin-biotin complex method. Fifty-one cases of squamous cell carcinoma and 10 cases of normal squamous epithelium of the uterine cervix were selected from the file which were treated during Jan. 89 to 31 Dec. 1992 in Department of Obstetrics and Gynecology, Korea University Hospital. RESULTS: UEA-1 and LTL were negative in normal cervix while positive in 76.5%, 47.1% of squamous cell carcinoma respectively, and useful markers for differential diagnosis between normal and squamous cell carcinoma. SBA and LTL were useful for differential diagnosis of keratinizing and non-keratinizing squamous cell carcinoma. UEA-1 may play an important role in lymphovascular invasion of squamous cell carcinoma of the uterine cervix. CONCLUSIONS: There was no correlation among clinical staging, patient's survival and lectins binding in squamous cell carcinoma.
Carcinoma, Squamous Cell* ; Cervix Uteri* ; Diagnosis, Differential ; Dolichos ; Epithelium ; Female ; Gynecology ; Humans ; Korea ; Lectins* ; Lotus ; Obstetrics ; Paraffin ; Soybeans ; Ulex

No abstract available.
Orbit*

PURPOSE: In mammals, alphaand beta-defensins are antimicrobial peptides that are expressed in various epithelial and phagocytic cells. Human beta-defensin-1 and -2 (hBD-1, hBD-2) have recently been shown to be expressed in various epithelial cells. Vaginal mucosa can be a target of vaginitis and the site of uropathogens' colonization that precedes urinary tract infections. Therefore, innate host defense mediators like antimicrobial peptides in the vaginal mucosa are important. Estrogen and progesterone receptors have been shown to be expressed in the vaginal squamous epithelium. Sex hormones like estrogen and progesterone may cause vaginal atrophy or susceptibility to uropathogens. So, we performed this study to investigate the expression patterns of hBD-1 and -2 mRNA in vaginal squamous epithelium (VSE) with using lipopolysaccharide (LPS), 17beta-estradiol and progesterone. MATERIALS AND METHODS: Normal VSE cells that were retrieved from vaginal tissue during vaginoplasty were primarily cultured in keratinocyte growth medium and they we allowed to undergo their 3rd passage. Modulation of the expressions of hBD-1 and -2 mRNA by various stimuli (LPS 0.5microgram/ml, E2 2nM, P 1micrometer) was measured by semiquantitative reverse transcription polymerase chain reaction (RT-PCR). RESULTS: HBD-1 and -2 were constitutively expressed in the normal VSE cell lines, but the hBD-2 expression was not significant. A marked increase of the constitutive expression of hBD-2 mRNA was observed upon stimulation with LPS, but not upon stimulation with E2. A moderate decrease of the constitutive expression of hBD-2 mRNA upon stimulation with LPS was observed with administering progesterone. CONCLUSIONS: These expressions of hBD-2 mRNA may have important roles in the innate host defense of the urogenital area. Artificial intake of progesterone may lead to susceptibility via a decrease of defensins.
Atrophy ; beta-Defensins ; Cell Line ; Colon ; Defensins ; Epithelial Cells* ; Epithelium ; Estrogens ; Gonadal Steroid Hormones ; Humans ; Keratinocytes ; Mammals ; Mucous Membrane ; Peptides ; Phagocytes ; Polymerase Chain Reaction ; Progesterone* ; Receptors, Progesterone ; Reverse Transcription ; RNA, Messenger ; Urinary Tract Infections ; Vagina ; Vaginitis

Purpose: New therapeutic approaches have emerged to improve gait ability in patients with brain damage, such as action observation learning (AOT), auditory cueing, motor imagery etc. We attempted to investigate the effects of AOT with auditory cueing (AOTAC) on gait function in patients with stroke. Methods: The eighteen stroke patients with a unilateral hemiparesis were randomly divided into three groups; the AOTAC, AOT, and control groups. The AOTAC group (n = 8) received training via observing a video that showed normal gait with sound of footsteps as an auditory cue; the AOT group (n = 6) receive action observation without auditory stimulation; the control group (n = 5) observed the landscape video image. Intervention time of three groups was 30 minutes per day, five times a week, for four weeks. Gait parameters, such as cadence, velocity, stride length, stance phase, and swing phase were collected in all patients before and after each training session. Results: Significant differences were observed among the three groups with respect to the parameters, such as cadence, velocity, stride length, and stance/swing phase. Post-hoc analysis indicated that the AOTAC group had a greater significant change in all of parameters, compared with the AOT and control groups. Conclusion Our findings suggest that AOTAC may be an effective therapeutic approach to improve gait symmetry and function in patients with stroke. We believe that this effect is attributable to the change of cortical excitability on motor related to cortical areas.

Purpose: To investigate the factors affecting intraocular pressure (IOP) change after prophylactic laser iridotomy (LI) in the fellow eye with acute angle closure glaucoma. Methods: Twenty-three subjects with acute primary angle closure glaucoma, who had undergone prophylactic LI in the fellow eye were enrolled in this study. IOP was measured before and 1 week after prophylactic LI. Compared with a week after and before the prophylactic LI, eleven eyes with the IOP reduction of 20% or more were classified into A group and twelve eyes with an IOP reduction of 20% or less were classified as B group. Anterior segment parameters were measured using anterior segment swept source optical coherence tomography. Results: The mean age, the best corrected visual acuity, the baseline IOP and the axial length were not significantly different between the two groups (p > 0.05). The IOP after prophylactic LI was significantly different between the two groups (group A 11.36 ± 1.96 mmHg, Group B 13.50 ± 1.83 mmHg; p = 0.013). There was a significant difference in IOP change rate of the two groups (Group A 29.78 ± 11.09%, Group B 9.14 ± 5.91%; p < 0.001). In multiple regression analysis, only the anterior chamber depth was significantly associated with the IOP change rate (p = 0.011). Conclusions The anterior chamber depth is associated with the change of IOP after prophylactic LI in the fellow eye with acute primary angle closure glaucoma. If the anterior chamber depth is shallow, it is highly likely that the change of IOP is relatively small. Therefore, the anterior chamber depth must be considered in assessing the effectiveness of prophylactic LI.

Purpose: To investigate the factors affecting intraocular pressure (IOP) change after prophylactic laser iridotomy (LI) in the fellow eye with acute angle closure glaucoma. Methods: Twenty-three subjects with acute primary angle closure glaucoma, who had undergone prophylactic LI in the fellow eye were enrolled in this study. IOP was measured before and 1 week after prophylactic LI. Compared with a week after and before the prophylactic LI, eleven eyes with the IOP reduction of 20% or more were classified into A group and twelve eyes with an IOP reduction of 20% or less were classified as B group. Anterior segment parameters were measured using anterior segment swept source optical coherence tomography. Results: The mean age, the best corrected visual acuity, the baseline IOP and the axial length were not significantly different between the two groups (p > 0.05). The IOP after prophylactic LI was significantly different between the two groups (group A 11.36 ± 1.96 mmHg, Group B 13.50 ± 1.83 mmHg; p = 0.013). There was a significant difference in IOP change rate of the two groups (Group A 29.78 ± 11.09%, Group B 9.14 ± 5.91%; p < 0.001). In multiple regression analysis, only the anterior chamber depth was significantly associated with the IOP change rate (p = 0.011). Conclusions The anterior chamber depth is associated with the change of IOP after prophylactic LI in the fellow eye with acute primary angle closure glaucoma. If the anterior chamber depth is shallow, it is highly likely that the change of IOP is relatively small. Therefore, the anterior chamber depth must be considered in assessing the effectiveness of prophylactic LI.

BACKGROUND: Vincristine is an antimitotic agent used for treatment of leukemia, lymphomas, and cancers. Its main side effect is a dose-related, length-dependent axonal neuropathy.METHODS: We performed electrodiagnostic examinations in 18 children who had been treated with vincristine and who presented with the clinical picture of a peripheral neuropathy.RESULTS: The mean cumulative dose of vincristine was 37.7±26.5 mg/m². Electrodiagnostic examination showed an axonal neuropathy with a length-dependent pattern. All patients showed motor nerve abnormalities and sensory nerve abnormalities were observed in 13 patients (72.2%). The number of affected nerves was 2.67±1.1 (mean±SD) of four motor nerves and 1.5±1.4 of four sensory nerves. The mean reduction of the compound muscle action potential amplitude was 70.9±42.2% in the median nerve and 23.7±20.8% in the peroneal nerve compared to normal value. However, the mean change in the sensory nerve action potential amplitude was 139.9±78.5% in the median nerve and 246.9±169.7% in the superficial peroneal nerve. There was statistically significant difference between amplitude reduction of the compound muscle action potential and sensory nerve action potential.CONCLUSION: The quantitative analysis of electrophysiological motor predominance described differs from the mainly sensory neuropathy reported in adults. Incomplete myelination in motor nerve due to young age may have resulted in greater sensitivity of some nerves to neurotoxic agents.
Action Potentials ; Adult ; Axons ; Child ; Drug Therapy ; Humans ; Leukemia ; Lymphoma ; Median Nerve ; Myelin Sheath ; Pediatrics ; Peripheral Nervous System Diseases ; Peroneal Nerve ; Polyneuropathies ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; Reference Values ; Vincristine

No abstract available.
Alcoholism* ; Mass Screening*

No abstract available.
Clothing* ; Dermatitis, Allergic Contact* ; Nickel*