Cohort studies are important observational epidemiological studies. In this perspective, we briefly introduced several ongoing prospective cohort studies of cardiometabolic diseases in China and in the U. S. , which have shaped our current understanding of cardiometabolic diseases. We hope that this perspective could shed lights on the research of chronic diseases such as diabetes and cardiovascular diseases.

Child ; Humans ; Male ; Thyroiditis, Suppurative ; pathology

OBJECTIVETo compare five materials commonly used in dentistry, including three types of metals and two types of ceramics, by using different sequences of three magnetic resonance imaging (MRI) field strengths (0.35, 1.5, and 3.0 T).

METHODSThree types of metals and two types of ceramics that were fabricated into the same size and thickness as an incisor crown were placed in a plastic tank filled with saline. The crowns were scanned using an magnetic resonance (MR) machine at 0.35, 1.5, and 3.0 T field strengths. The TlWI and T2WI images were obtained. The differences of various materials in different artifacts of field MR scans were determined.

RESULTSThe zirconia crown presented no significant artifacts when scanned under the three types of MRI field strengths. The artifacts of casting ceramic were minimal. All dental precious metal alloys, nickel-chromium alloy dental porcelain, and cobalt-chromium ceramic alloy showed varying degrees of artifacts under the three MRI field strengths.

CONCLUSIONZirconia and casting ceramics present almost no or faint artifacts. By contrast, precious metal alloys, nickel-chromium alloy dental porcelain and cobalt-chromium ceramic alloy display MRI artifacts. The artifact area increase with increasing magnetic field.

Artifacts ; Ceramics ; Chromium Alloys ; Crowns ; Dental Alloys ; Dental Materials ; Dental Porcelain ; Magnetic Fields ; Magnetic Resonance Imaging ; Zirconium

Aged ; Aged, 80 and over ; Humans ; Male ; Porokeratosis ; genetics ; Rectal Neoplasms ; genetics

Crush Syndrome ; therapy ; Disasters ; Earthquakes ; Humans

Adolescent ; Adult ; Child ; Dexamethasone ; administration & dosage ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; administration & dosage ; Female ; Humans ; Male ; Middle Aged ; Phytotherapy ; Rhinitis, Allergic, Perennial ; therapy ; Volatilization

512 ?g/ml for vancomycin.Thirty seven VanA genes were detected in 37 VREFm.The drug resistance rates to erythromycin,ampicillin,levofloxacin,gentamicin,ciprofloxacin,nitrofurantoin(Euradantin) and chloramphenicol were 100.0%,100.0%,89.2%,86.5%,91.9%,59.5%,and 5.4%,respectively.The REP-PCR generated 3-14 bands between 100 and 2000bp.They were divided into six types.CONCLUSIONS There is 100.0% agreement between phenotypes and genotypes in VREFm.VREFm are multiresistant.REP-PCR method is simple,rapid,and with lower cost to detect the homology in enterococci.

Objective:To investigate the inhibitory effect of antisense oligodeoxynucleotide (ASODN) targeting survivin gene on gastric cancer cell line SGC-7901. Methods: Cultured SGC-7901 cells were divided into 6 groups: control group, lipofectin group, oligodeoxynucleotide(ODN) group, 1?10-5mol/L ASODN group, 3?10-5mol/L ASODN group and 5?10-5mol/L ASODN group. After incubated with ASODN, the expression of survivin mRNA in the SGC-7901 cells was examinated by PCR; the apoptosis of SGC-7901 cells was studied by the morphological observation using inverted microscope, electron microscope, flow cytometry and DNA agarose electrophoresis; telomerase activity was determined using PCR-based TRAP (telomere repeat amplification protocol) assay; MTT assay was used to study the inhibitory effect of ASODN on the proliferation of SGC-7901 cells. Results: ASODN obviously inhibited the expression of survivin mRNA in the SGC-7901 cells. The apoptotic rate of gastric cell was significantly increased after incubated with ASODN ([7.01?0.21]% vs [25.0?0.52]%, P

OBJECTIVE To study the distribution and drug resistance of pathogens in urinary tract infection from elderly patients.METHODS A total of 406 strains isolated from urine culture of the elderly patients were identified and their drug resistance was tested by K-B method.RESULTS Among 406 strains the Gram-negative bacilli accounted for 67.0%.The majority of Gram-negative bacilli were Escherichia coli(156 strains),Proteus,Klebsiella pneumoniae,Enterobacter cloacae,Pseudomonas aeruginosa,and Acinetobacter baumannii.Grampositive cocci accounted for 29.1% and Candida albicans accounted for 4.0%,respectively.The resistance rate of the main Gram-negative bacilli to imipenem,cefoperazone/sulbactam and amikacin was relatively low.And all Gram-positive cocci were sensitive to vancomycin.CONCLUSIONS The antimicrobial resistance of pathogens in elderly patients with urinary tract infection is serious.So it is important to monitor the antimicrobial resistance.

Objective To analyze the effect of modified Yulin Decoction on hormones and ovarian function in patients with premature ovarian failure (POF).Methods 142 cases of patients with POF and kidney-yang deficiency syndrome were selected and randomLy divided into the control group (n=64) and the observation group (n=78).Levels of serum hormones and ovarian function,the traditional Chinese medicine (TCM) symptom score in the two groups were observed before and after treatment.Results Before treatment, there were no significant differences between the two groups in the scores and levels of hormones.After treatment, levels of serum FSH, LH and E2 were significantly decreased in the two groups, and the changes were more obvious in the observation group than the control group (P<0.05).After treatment, TCM symptom scores of two groups were significantly decreased, and the observation group were significantly lower than those in the control group (P<0.05).Conclusion Modified Yulin Decoction is significantly effective in the treatment of POF of spleen and kidney-yang deficiency syndrome.It can significantly improve the level of estrogen, adjust endocrine and relieve clinical symptoms.