CD8-Positive T-Lymphocytes ; immunology ; Dendritic Cells ; immunology ; Hepatitis B ; immunology ; therapy ; Hepatitis B Surface Antigens ; immunology ; Humans

Objective　To introduce the development of therapy of hilar cholangiocarcinoma. Methods　This summarization paper was made on the literatures review. Results　Extended radical resection, neoadjuvant chemotherapy, orthotopic liver transplantation, photodynamic therapy and molecular chemoradiotherapy might improve the survival rate. Conclusions　Surgical resection combined with other theraputic methods is the main treatment for hilar cholangiocarcinoma.

Objective]To observe the clinical effect in treating cystic acne with combination of Yu Shi San Gen Tang and minocycline. [Methods] 120 patients with cystic acne were randomly divided into 3 groups,40 cases in treatment group treated with Yu Shi San Gen Tang and minocycline,40 cases in control group1treated with minocycline and 40 cases in the control group 2 treated with Yu Shi San Gen Tang. These patients were observed the effect after continuously treated for 8 weeks. [Results] In treatment group,15 cases were cured,18 were effective,the total effective rate was 82.5%. In control group1,they were respectively 9,13 and 55%. In control group 2,they were respectively 10,14 and 60%,with significant difference between treatment group and control group1,control group2,and no significant difference between control group 1 and control group 2. [Conclusion] The combination of Yu Shi San Gen Tang and minocycline has a significant curative effect on cystic acne.

Objective: To investigate the influence of the composite chitosan/ heparin coated membrane through a layer-by-layer self-assemble technique on stent thrombosis. Methods: The composite chitosan/heparin coated membrane, which was assembled through a layer-by-layer technique,was attached to the inside surface of cylinder made from 316L stainless steel flake to form membranes of different layers of chitosan/heparin. The activated partial thromboplastin time (APTT),prothrombin time (PT) and thrombin time (TT) of the whole blood samples of healthy controls were examined by clotting method; and the stability of its anticoagulation effect was also examined. The influence of the prepared composite chitosan/heparin coated membrane on coronary stent thrombosis was investigated using swine model of arteriovenous shunt thrombus. Results: The APTT and TT were significantly longer in the composite coated membrane group compared with those of 316L stainless steel group (P < 0.01). Moreover, the prolongation of APTT and TT was correlated with the increase of coated layers. The anticoagulant function of chitosan/heparin coated membrane was stable for two weeks(P>0.05). The weight of thrombus was significantly lower in the coated stent group than that in 316L stainless steel group(P<0.001). Conclusion: The composite chitosan/heparin coated membrane made by layer-by-layer self-assemble has effective and stable anti-thrombotic function.

Anniversaries and Special Events ; Humans ; Learning ; Medicine, Chinese Traditional ; Physicians

OBJECTIVE:To evaluate the therapeutic effect of Ornidazole on the anaerobic infections after maxillofacial plastic surgery.METHODS:40patients suffering from anaerobic infections after maxillofacial plastic surgery were randomly divided into two groups.One group was treated with injection of Ornidazole,while another group treated with Metronidazole injection seved as control.The clinical effects and bacteria clearance rates were compared between two groups.RESULTS:The curative effect was65%in the trial group and40%in control group,which existed a significant difference(P

Background:Serum levels of pepsinogen( PG),gastrin-17( G-17)and Helicobacter pylori( Hp)infection are closely associated with gastric cancer. Studies on relationship of serum levels of PG and G-17 with Hp infection in Uygur and Han population with gastric cancer in Xinjiang area are rare. Aims:To investigate serum levels of PG and G-17 and their relationships with Hp infection in Uygur and Han population with gastric cancer in Xinjiang area. Methods:A total of 198 Uygur and 50 Han gastric cancer patients were enrolled,and healthy people with the same race were served as normal controls. Serum levels of PGⅠ,PGⅡ,G-17 were determined by ELISA,PGⅠ/ PGⅡ ratio(PGR)was calculated. Urea breath test and stool Hp antigen test were used to detect Hp infection. Results:Serum PGⅠ level and PGR in Uygur and Han patients with gastric cancer were significantly decreased than those in corresponding control groups(P < 0. 05),and serum levels of PGⅡ and G-17 were significantly increased(P < 0. 05). Serum PGⅠ level and PGR in Uygur gastric cancer patients were significantly decreased than those in Han gastric cancer patients(P < 0. 05),and serum G-17 level was significantly increased(P < 0. 05). Hp infection rate in Uygur and Han patients with gastric cancer were significantly increased than those in corresponding control groups( P < 0. 05). Serum level of PG Ⅰ and PGR were significantly decreased in Han gastric cancer patients with Hp-positive than in Hp-negative patients,and serum levels of PGⅡ and G-17 were significantly increased(P < 0. 05). Serum levels of PGⅠ,PGⅡ and G-17 were significantly increased in Uygur gastric cancer patients with Hp-positive than in Hp-negative patients,PGR was significantly decreased(P < 0. 05). Serum levels of PGⅠ,PGⅡ and PGR were significantly increased in Uygur gastric antral cancer patients than in gastric corpus cancer and proximal gastric cancer patients(P < 0. 05). Conclusions:Decreased serum PGⅠ level,PGR and increased serum level of G-17 can be used as biomarkers to screen gastric cancer in Uygur and Han population in Xinjiang area. Hp infection in Uygur and Han patients with gastric cancer is related to the changes of serum level of PGⅠ,PGR and G-17.

Chemotherapy has been widely used in treating patients with colorectal cancer(CRC).Despite the tremendous progress achieved in cancer treatment during the last decades, drug resistance remains a major obstacle to effective treatment for CRC. Emerging evidence shows that microRNAs (miRNAs) play an important role in regulating the drug sensitivity of tumor cells. This review aimed to summarize the association of microRNA expression with chemotherapy in colorectal cancer.

Objective To observe the clinical efficacy of triple needling and centro-square needling in treating hemifacial spasm. Method Sixty-eight patients with facial spasm were randomized into a treatment group and a control group, 34 in each group. The treatment group was intervened by centro-square needling at topical Ashi points and triple needling at Yifeng (TE 17) on the affected side; the control group was intervened by regular acupuncture. The two groups were treated once a day, 10 times as a treatment course, for 3 courses in total. Cohen Albert grading scale was adopted to evaluate the spasm intensity before and after the intervention, and the clinical efficacies were then compared.Result After intervention, there was a significant difference in comparing the spasm intensity between the two groups (P<0.05). The significant improvement rate was 88.2% in the treatment group versus 50.0% in the control group, and the difference was statistically significant (P<0.05).Conclusion Triple needling plus centro-square needling is an effective method in treating hemifacial spasm. This method uses less points, but it produces a high efficacy, strong pertinence, and is easy-to-operate.