Renal scarring can cause hypertension, proteinuria, chronic kidney disease, and even end stage renal disease. To understand the risk factors of renal scarring in children is helpful for its early detection, diagnosis, prevention, and treatment. High grade vesicoureteric reflux, recurrent urinary tract infection, and delayed treatment are risk factors for kidney scarring. However, there are still some controversies about the relationship between renal scarring and the some factors such as gender, age, and congenital factors. Recent studies have found that noninvasive urine indicators such as urine neutrophil gelatinase associated lipid delivery protein, urinary endothelin-1, and risk prediction models can predict the formation of renal scar. However, prophylactic use of antibiotics can reduce occurance of urinary tract infections, but do not reduce the risk of renal scarring. This article reviews the possible risk factors and predictors of renal scarring in children, providing a basis for early detection, timely intervention, and effective prevention of it in clinic, so as to reduce the formation and progression of renal scarring.

[Objective]To study the regulation effects of Oridonin on pulmonary artery pressure in pulmonary hypertension rats with hypoxia-hypercapnia and its mechanism.[Methods]SD rats were divided in to three groups randomly: the normal control group(NC),the hypoxia-hpercapnia group(HH),and the hypoxia-hpercapnia plus Oridonin group(O).The time of hypoxia-hypercapnia was 4 weeks.The mean pulmonary artery pressure(mPAP),right ventricular rate(RV/(LV+S)),percentage of thickness of pulmonary artery wall in vascular external diameter(WT%),percentage of pulmonary artery wall area in total vascular area(WA%),vitality of caspase3 and caspase9,expression cyt-c of each group were observed.[Results]The mPAP,RV/(LV+S),WT%,WA% in group HH were significantly higher than those in group NC(P

Administration, Topical ; Humans ; Immunosuppressive Agents ; administration & dosage ; adverse effects ; therapeutic use ; Lichen Planus, Oral ; complications ; drug therapy ; pathology ; Oral Ulcer ; drug therapy ; etiology ; Tacrolimus ; administration & dosage ; adverse effects ; therapeutic use ; Treatment Outcome

ObjectiveTo study the clinical effect of sodium aescinate on the edema of limb tibial plate fracture.Methods69 patients with edema of limb of tibial plate fracture were randomly divided into two groups,treatment group(46 cases)and control group(23 cases).Both of them were transfused with 20％ mannitol(250ml,Bid ×7days).In addition,these patients in the treatment group were treated with sodium aescinate(30mg Qd × 7days).ResultsThe repercussive effect of the edema grade in the treatment group were obviously better than those in the control group(P ＜0.05 ).ConclusionSodium aescinate had a remarkable repercussive effect on the limb edema of tibial plate fracture.

Objective To evaluate the treatment of acne vulgaris with acupuncture by different methods of point selection.Methods 51 cases of acne vulgaris were randomly recruited into local point selection group,distal point selection group and combination of local and distal point selection group.10 cases of healthy people were recruited for normal control group.Serum arachidonic acid (AA),free testosterone (FT),and sex hormone binding globulin (SHBG) levels were observed in all treatment groups.Results After the treatment,serum AA was (20.56±5.28)μg/L,(18.86±5.70) μg/L and (14.62±3.06) μg/L,while SHBG was (333.31±87.96) nmol/L,(332.02±87.82) nmol/L and (273.02±61.74) nmol/L respectively in local point selection group,distal point selection group and combination of local and distal point selection group,both showing no significant difference than the normal control group (P＞0.05).There was no significant difference in FT value between the combination of local and distal point selection group (5.62± 1.98) nmol/L and the normal control group (P＞0.05).The decrease of AA in the combination of local and distal point selection group was between than the local point selection group (P＜0.01).Conclusion Acupuncture can effectively improve the level of inflammatory factors and androgen of the acne vulgaris.Different methods of point selection of acupuncture on the improvement of some indicators were quite different,which laid the foundation for the best compatibility of acupuncture treatment in acne vulgaris.

Objective To analyze the clinical presentation and maternal neonatal outcome of 30 cases with HELLP syndrome and to discuss the diagnosis, treatment and prognosis of the disease. Methods 30 cases of HELLP syndrome were collected retrospectively including 19 cases of complete HELLP syndrome and 11 partial HELLP syndrome. The blood test, clinical presentations, complications and pregnant outcomes were analyzed. Results LDH value in complete HELLP group(CHG) [(622?481)U/L] was significantly higher than that in partial HELLP group(PHG) [( 369?101) U/L, P

Glucose-6-phosphatase(G-6-Pase) activity in the atrial and ventricular muscle cells of the rats is examined by electron microscopy. The reaction product of G-6-Pase activity is present in the sarcoplasmic reticulum (SR) and the nuclear envelope of the myocardial cells. A heterogenous distribution of G-6-Pase activity in the cardial muscle cells is detected.In the myocardial cells the cytochemical reaction product for G-6-Pase activity is observed in a larger amount in the peripheral junctional sarcoplasmic reticulum(PJ-SR)and interior junctional SR(IJ-SR), and in smaller amounts in the nuclear envelope, is rarely present or absent in the network SR(N-SR).The possible functional significance of G-6-Pase in cardial muscle cells is discussed.

Objective To investigate The effect of TAM(2.5 uM)in the chemotherapy of HCC and its mechanism. Methods An adriamycin-resistant human HCC cell subline(Hep-3B/ADM)was established,through exposure to gradually increased concentration of ADM.Drug sensitivity was measured by MTT.Modulation of ADM-induced apop- tosis of Hep-3B/ADM cells was assessed by Flow cytometry(FCM).PKC activity was determined by applying compet- itive protein binding method.Results TAM(2.5uM )decreased the IC50 of ADM from 1.64?g/mL to 0.23?g/mL in the Hep-3B/ADM cells.TAM exhibited a 2-fold potentiation on apoptosis caused by ADM in Hep-3B/ADM cells.With TAM,PKC activity was lower than that in control groups from 30 seconds to 24 hours.But this effect of TAM could be reversed by the co-treatment of the cells with TPA.Conclusion TAM(2.5 uM)significantly en- hanced ADM-induced cytotoxicity.The mechanism is that TAM potentiates the apoptosis induced by ADM through pro- tein kinase C inhibition.

Objective To explore the psychological intervention combined with intracapsular injection of kidney fat in the treatment of nephropathy clinical analysis, looking for effective treatment.Methods 140 patients with nephropathy were enrolled in our hospital from March 2014 to September 2016.Patients were randomly divided into study group(n=70) and control group(n=70) according to the international character table method.Group of patients with a single renal fat capsule drug injection therapy, the study group to be combined with psychological intervention + kidney fat intracapsular injection of drug treatment, the treatment cycle after the end of two groups of patients compared with 24 hours of urine protein quantification, urine microalbumin;The incidence of adverse events in the two groups of patients was compared between the two groups of patients with emotional status(SAS, SDS scale).Results The levels of urinary albumin in the study group were(139.75±20.04) μg/min, and the 24h urine protein level was(1.43±0.59) g/24h significantly lower than the control group(189.74±19.54) μg / min,(4.77±2.14) g / 24h(P<0.05).The incidence of adverse reactions in the study group was 4.29%, which was lower than that of the control group(7.14%).However, there was no significant difference between the two groups.The self-rating scale of the study group(32.35±2.19)(38.65±3.54) points were lower than the control group(55.97±2.14) points,(54.21±7.89) points(P<0.05).Conclusion Psychological intervention combined with intracapsular injection of renal capsule can significantly improve the renal function of patients, can interfere with the patient's bad mood, and high security, health care workers can be promoted.

The arterial supply of the human sacrum and coccyx was studied on 56 fresh. cadavers of different ages by dissection, clearing, casting and radiography.All sacrums receive their blood supply from the lateral sacral arteries, the median sacral artery, the iliolumbar arteries and the fifth lumbar arteries. The median sacral artery, the lateral sacral arteries and their branches anastomose with each other and form the lattice anastomosis on the ventral surface of the sacrum.The anterior spinal canal branch bifurcates into an ascending and a descending branches. The former passes upwards to join the descending branch from the anterior spinal canal branch above it, they also anastomose with their contralateral counterparts, thus forming a rhombic system notable for its regularity.The posterior spinal canal branch also divides into an ascending and a descending branches and they join each other to dispose in a ladder anastomosis on the ventral surface of the laminae.The dorsal branch gives off three main sets of branches: the lateral, the medial and the muscular. The medial and the lateral branches both subdivide into an ascending and a descending branches and they anastomose with each other on the dorsal aspect of the sacrum.On the ventral surface, the coccyx obtains arterial supply from the median sacral artery and the lateral sacral arteries, while its dorsal surface mainly receives blood supply of the lateral sacral artery. Anastomosis has been found scarce on the ventral and dorsal surfaces of the coccyx.