1.A Clinical Observation on Injuries of Genito-urinary Tract.
Hee Chung AHN ; In Soo YU ; Sang Gun CHOI ; Kun Won CHOO
Korean Journal of Urology 1964;5(2):111-116
This is to report a clinical observation on 81 cases of genito-urinary tract injuries treated at the urology service. Capital Army Hospital, during the period from January, 1960 to July, 1963. Of 81 Cases which stood for 0.82% of all genito-urinary out patients, 58 cases (or 71.6%) occurred in the urethra, the most common site of involvement, and 6 cases (or 7.2%) showed multiple injuries. Age ranged between 21 and 10 years with the highest incidence of 58.4% in the ages between 21-25 years. In lateralyzation of injury while the kidney showed nosignificant difference the ureter was more frequently involved in the left than in the right with a ratio of 4:1. Traffic accident was listed as high as 56.9% to be most frequent cause of injury and contusion, fall, gun-shot and explosion were listed less frequently. Of associated major injuries, pelvic fracture was seen in 20 cases (33.9%) and all the urethral injuries were accompanied with injuries to gastro-intestinal tract. Of all cases herein reported, 62.3% of cases were treated surgically and the remaining 37.7%. non-surgically. Surgical intervention was necessary in 33.3% of kidney injury, 100% of ureteral injury, 67.8% of urethral injuries and 40% of genital injuries. Average hospitalization required 20.2 days for renal injury and 67.2 days for urethral injury.
Accidents, Traffic
;
Contusions
;
Explosions
;
Hospitalization
;
Hospitals, Military
;
Humans
;
Incidence
;
Kidney
;
Multiple Trauma
;
Outpatients
;
Ureter
;
Urethra
;
Urology
2.Acute Appendicitis Diagnosed by Colonoscopy.
Jae Myung YU ; Tae Hun AHN ; Hyung Ho LEE ; Ho Sang RYU ; Jin Hai HYUN
Korean Journal of Gastrointestinal Endoscopy 1986;6(1):55-58
Acute appendicitis is the most common operative disease in general surgery, but it is not also rate disease to see in other clinical department such as Internal Medicine and Obstetric and Gynecology, because it reqnires to differenciate from many other diseases which have similar symptoms. Expecially, because the clipical aymptoms of acute appendicitis are not typieal in children, elderly, and women, it is hard to be diagnosed as acute appendicitis and it is often misdiagnosed as other disease. We performed colonoscopy due to be interpretated aa one of the colon diseases rather than acute appendicitis. But in colonoscopic findings, there were hyperemie and edematous change on the appendiceal orifice of cecum(cherry or acorn shape). So we report 5 cases of acute appendicitis diagnosed br colonoscopy.
Aged
;
Appendicitis*
;
Child
;
Colon
;
Colonoscopy*
;
Female
;
Gynecology
;
Humans
;
Internal Medicine
4.The Effects of Facet Joint Injection in Osteoporotic Spinal Compression Fractures.
Hee Sang KIM ; Seung Don YU ; Kyung Hoi AHN
Journal of the Korean Academy of Rehabilitation Medicine 2000;24(3):550-557
OBJECTIVE: To evaluate the effects of facet joint injection in the conservative management of osteoporotic spinal compression fractures METHOD: Among 27 patients with osteoporotic spinal compression fractures which were confirmed by plain radiography and bone densitometry (dual energy x-ray absorptiometry), 9 patients were control group and 18 patients received facet joint injection treatment. Facet joint injection of thoracolumbar spine was done under fluoroscopic guide with 1% lidocaine 1 ml and triamcinolone 10 mg at each joint above and below the level of compression fracture at both side. Main outcome measures were visual analog scale (VAS), spinal movement (modified Schober's and lateral bending test), and physical activity from bed-ridden state (grade I) to outdoor activity without pain (grade V). The treatment outcomes were assessed before injection, 2 weeks and 4 weeks after injection. RESULTS: There were significant decrease in VAS at 2 weeks and 4 weeks after injection in the study group (p<0.05). Physical activity was significantly improved at post injection 2 weeks and 4 weeks (p<0.05). There were no significant differences between the two groups in spinal movement. CONCLUSION: These results suggest that facet joint injection of thoracolumbar spine is useful method in the conservative management of painful osteoporotic compression fractures.
Densitometry
;
Fractures, Compression*
;
Humans
;
Joints
;
Lidocaine
;
Motor Activity
;
Outcome Assessment (Health Care)
;
Radiography
;
Spine
;
Triamcinolone
;
Visual Analog Scale
;
Zygapophyseal Joint*
5.A Case of Small Cell Neuroendocrine Carcinoma in the Parotid and Lacrimal Glands.
Chai Kyu YU ; Sang Tae AHN ; Jae Gu PARK ; Poong LIM
Journal of the Korean Society of Plastic and Reconstructive Surgeons 2001;28(1):67-69
Small cell carcinoma is most frequently found in the lung. Extrapulmonary sites of this neoplasm account for only 4% of all small cell carcinomas. Small cell carcinomas arising in the salivary glands are extremely rare, accounting for less than 1% of all parotid gland carcinomas. A 72-years- old women visited our clinic to evaluate hard protruding masses in the left preauricular region and the left orbit. Superficial parotidectomy and incisional biopsy for orbital mass revealed small cell neuroendocrine carcinoma. As the extrapulmonary small cell neuroendocrine carcinoma, arising in both left parotid and lacrimal glands is reported rarely in the world and not reported in Korea yet, we report its clinical progress.
Biopsy
;
Carcinoma, Neuroendocrine*
;
Carcinoma, Small Cell
;
Female
;
Humans
;
Korea
;
Lacrimal Apparatus*
;
Lung
;
Orbit
;
Parotid Gland
;
Salivary Glands
6.A Study on the Synthesis and Its Biodistribution of C - 11 and F - 18 Labelled Choline.
Seung Dae YANG ; Sang Wook KIM ; Yong Sup SUH ; Kwon Soo CHUN ; Soon Hyuk AHN ; Min Goo HUR ; Sang Moo LIM ; Sung Woon HONG ; Kook Hyun YU
Korean Journal of Nuclear Medicine 2001;35(3):185-191
No abstract available.
Choline*
7.Analysis of Heavy Metals in 201TlTlCl Injection Using Polarography.
Kwon Soo CHUN ; Yong Sup SUH ; Seung Dae YANG ; Soon Hyuk AHN ; Sang Wook KIM ; Kang Hyuk CHOI ; Dong Hoon LEE ; Sang Moo LIM ; Kook Hyun YU
Korean Journal of Nuclear Medicine 2000;34(4):336-343
PURPOSE: Thallous-201 chloride produced at Korea Cancer Center Hospital(KCCH) is used in detecting cardiovascular disease and cancer. Thallium impurity can cause emesis, catharsis and nausea, so the presence of thallium and other metal impurities should be determined. According to USP and KP, their amounts must be less than 2 ppm in thallium and 5 ppm in total. In this study, the detection method of trace amounts of metal impurities in [201Tl]TlCl injection with polarography was optimized without environmental contamination. MATERALS AND METHODS: For the detection of metal impurities, Osteryoung Square Wave Stripping Voltammetry method was used in Bio-Analytical System (BAS) 50W polarograph. The voltammetry was composed of Dropping Mercury Electrode (DME) as a working electrode, Ag/AgCl as a reference electrode and Pt wire as a counter electrode. Square wave stripping method, which makes use of formation and deformation of amalgam, was adopted to determine the metal impurities, and pH 7 phosphate buffer was used as supporting electrolyte. RESULTS: T1, Cu and Pb in thallous-201 chloride solution were detected by scanning from 300 mV to -800 mV. Calibration curves were made by using TlNO3, CuSO4 and Pb(NO3)2 as standard solutions. Tl was confirmed at -450 mV peak potential and Cu at -50 mV. Less than 2 ppm of Tl and Cu was detected and Pb was not detected in KCCH-produced thallous-201 chloride injection. CONCLUSION: Detection limit of thallium and copper is approximately 50 ppb with this method. As a result of this experiment, thallium and other metal impurities in thallous-201 chloride injection, produced at Korea Cancer Center Hospital, are in the regulation of USP and KP. Polarograph could be applied for the determination of metal impurities in the quality control of radiopharmaceuticals conveniently without environmental contamination.
Calibration
;
Cardiovascular Diseases
;
Catharsis
;
Copper
;
Electrodes
;
Hydrogen-Ion Concentration
;
Korea
;
Limit of Detection
;
Metals, Heavy*
;
Nausea
;
Polarography*
;
Quality Control
;
Radiopharmaceuticals
;
Thallium
;
Vomiting
8.Effects of Antiplatelet Agents on the Graft Survival in Murine Cardiac and Skin Transplantation Model.
Seong Yup KIM ; Sang Hyun AHN ; Sang Il MIN ; Si Hwa KIM ; Yu Jin JEONG ; Seung Kee MIN ; Sang Joon KIM ; Jongwon HA
The Journal of the Korean Society for Transplantation 2011;25(1):31-37
BACKGROUND: At the initiation of immunologic response, platelets rapidly release chemical mediators which may induce rejection of transplanted organ. The purpose of this study was to investigate the effect of antiplatelet agents in murine cardiac and skin transplantation models. METHODS: In the minor major histocompatibility (MHC) mismatch model, BALB/c (H2d) mice underwent heart transplantation from B10.D2 (H2d) mice. In the major MHC mismatch model, CBA (H2k) mice were used as the recipients and C57BL/10 (H2b) mice as donors. The recipients were divided into four groups and each group was treated with distilled water (DW), sarpogrelate, cilostazol, or clopidogrel respectively. For skin transplantation, the recipients in the minor MHC mismatch model were divided into four groups similar to those in cardiac transplantation. The recipients in the major MHC mismatch model were divided into DW-treated and sarpogrelate-treated groups. All treatments were done by the per oral route of administration. RESULTS: For graft survival in the minor MHC mismatch model of cardiac transplantation, sarpogrelate-treated group showed increased median survival time (MST) compared to the other groups (DW-treated group 17.5 days, sarpogrelate-treated group 88 days, cilostazol-treated group 13 days, clopidogrel-treated group 23 days). Similar results were observed in the major MHC mismatch model. In the major MHC mismatch model, the expression of adhesion molecules (L-selectin, intercellular adhesion molecule-1 [ICAM-1], Mac-1, lymphocyte function associated antigen-1 [LFA-1]) was significantly higher in DW-treated group compared to sarpogrelate-treated group (P<0.05) In the minor MHC mismatch model, MST in the antiplatelet-treated skin graft group was not remarkably prolonged compared to DW-treated group. In the major MHC mismatch model, sarpogrelate-treated group showed prolonged survival compared to DW-treated group (MST 25 vs. 19 days, P<0.05). There was no statistically significant difference in the proportion of activated T cells and regulatory T cells. CONCLUSIONS: The tendency for a better survival of grafts was observed in the sarpogrelate-treated skin and heart transplant group compared to DW-treated group. However, further mechanistic study is necessary to these results.
Animals
;
Blood Platelets
;
Graft Survival
;
Heart
;
Heart Transplantation
;
Histocompatibility
;
Humans
;
Intercellular Adhesion Molecule-1
;
Lymphocytes
;
Mice
;
Platelet Aggregation Inhibitors
;
Rejection (Psychology)
;
Skin
;
Skin Transplantation
;
Succinates
;
T-Lymphocytes
;
Tetrazoles
;
Ticlopidine
;
Tissue Donors
;
Transplants
;
Water
9.Safety and Immunogenicity of a Pseudomonas aeruginosa Outer Membrane Protein Vaccine(CFC-101) : a Phase I/IIa Clinical Trial.
In Jin JANG ; Ik Sang KIM ; Kyung Sang YU ; Dong Suk YIM ; Hyung Ki KIM ; Sang Goo SHIN ; Woo Hyun CHANG ; Wan Je PARK ; Na Gyong LEE ; Sang Bo JUNG ; Dong Ho AHN ; Yang Je CHO ; Bo Young AHN ; Younha LEE ; Young Gi KIM ; Sung Woo NAM ; Hyun Su KIM
Korean Journal of Infectious Diseases 1998;30(3):267-277
BACKGROUND: We developed a Pseudomonas aeruginosa outer membrane protein(OMP) vaccine, CFC-101, and the prophylactic efficacy of which has been demonstrated in animal models. In order to evaluate the safety and immunogenicity of the P. aeruginosa vaccine, we carried out a phase I/IIa clinical trial in healthy male volunteers. METHODS: Groups of eight volunteers, including two placebo subjects, were vaccinated intramuscularly with three doses of 0.25, 0.5 or 1.0 mg of the vaccine at one week intervals. Signs of systemic and local reactions observed after vaccination were recorded for each vaccinee for 5 days. Physical examinations were performed on days 0, 1, 7, 8, 14, 15, 21, and 42, and clinical laboratory tests were done on days 0, 3, and 21. Blood samples for assay of serum antibody levels were obtained up to 42 days after the first vaccination. RESULTS: The vaccine was generally well tolerated by all vaccinees, showing no significant side effects. In the three dosage groups, all vaccinees, except one receiving the 0.25 mg dose, showed significant elevation in serum IgG antibody titers against the vaccine proteins, indicating 100% seroconversion in 0.5 and 1.0 mg groups. The human antibodies induced by the vaccine were specific for P. aeruginosa OMPs, as confirmed by western blot analysis and immunoprecipitation assays. The capacity of the human antisera to enhance opsonophagocytic killing activity by polymorphonuclear leukocytes and to confer protection against P. aeruginosa infections indicates that the antibodies elicited by the vaccine have protective efficacy. CONCLUSION: We conclude that the P. aeruginosa OMP vaccine is safe and effective for human use and its optimal dose to be 0.5 or 1.0 mg.
Antibodies
;
Blotting, Western
;
Homicide
;
Humans
;
Immune Sera
;
Immunoglobulin G
;
Immunoprecipitation
;
Male
;
Membrane Proteins*
;
Membranes*
;
Models, Animal
;
Neutrophils
;
Physical Examination
;
Pseudomonas aeruginosa*
;
Pseudomonas*
;
Vaccination
;
Volunteers
10.Bacterial Growth in Amniotic Fluid Is Dependent on the Iron-Availability and the Activity of Bacterial Iron-Uptake System.
Young Joon AHN ; Sang Kee PARK ; Jae Wook OH ; Hui Yu SUN ; Sung Heui SHIN
Journal of Korean Medical Science 2004;19(3):333-340
In the present study, the relationship among iron-availability, antibacterial activity, role of meconium as an iron source and the activity of bacterial iron-uptake system (IUS) for bacterial growth in amniotic fluid (AF) were investigated. Staphylococcus aureus ATCC 6538 and its streptonigrin-resistant (SR) mutant with defective IUS were used as the test strains. The growth of S. aureus in AF was stimulated dosedependently by addition of meconium. Bacterial growth stimulated by meconium was re-inhibited dose-dependently by addition of iron-chelator, dipyridyl and apotransferrin. Iron concentration was correlated with the meconium content in AF (r(2)= 0.989, p=0.001). High-affinity IUS of S. aureus was expressed only in AF but not in AF with meconium. The growth of SR strain was more retarded than that of the parental strain in the iron-deficient brain heart infusion (ID-BHI), clear AF and AF containing apotransferrin. The retarded growth of both strains in the ID-BHI and AF was recovered by addition of holotransferrin, hemoglobin and FeCl3. Taken together, the antibacterial activity of AF is closely related with low iron-availability. Bacterial growth in AF considerably depends on the activity of bacterial IUS. Meconium acts as one of the exogenous iron-sources and thus can stimulate bacterial growth in AF.
Amniotic Fluid/*microbiology
;
Antibiotics, Antineoplastic/pharmacology
;
Chelating Agents/pharmacology
;
Dose-Response Relationship, Drug
;
Female
;
Ferric Compounds/pharmacology
;
Human
;
Iron/*metabolism
;
Ligands
;
Meconium/metabolism
;
Mutation
;
Pregnancy
;
Pregnancy Trimester, Third
;
Protein Binding
;
Staphylococcus aureus/metabolism
;
Streptonigrin/pharmacology
;
Support, Non-U.S. Gov't
;
Time Factors